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Carbapenemase-producing Elizabethkingia meningoseptica from healthy pigs associated with colistin use in Spain

Investigation published in Antibiotics

September 11st, 2019

Carbapenems are considered last-resort antimicrobials, especially for treating infections involving multidrug-resistant Gram-negative bacteria. In recent years, extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Gram-negative bacteria have become widespread in hospitals, community settings, and the environment, reducing the range of effective therapeutic alternatives. The use of colistin to treat infection caused by these multi-drug bacteria may favour the selection and persistence of carbapenem-resistant bacteria. In this study, it is described, for the first time to our knowledge, a carbapenemase-producing isolate of Elizabethkingia meningoseptica from healthy pigs in Spain. The isolate we report was recovered during a study to detect colistin-resistant bacteria from faecal samples of healthy food-production animals using a chromogenic selective medium. Unexpectedly, we found an isolate of Elizabethkingia eningoseptica with high Minimum Inhibitory Concentration (MIC) values for several antibiotics tested. Molecular analysis did not show
any mcr family genes related with colistin resistance, but two carbapenemase genes, blaB-12_1 and blaGOB-17_1, were detected. This finding in healthy animals could suggest that colistin may favour the selection and persistence of carbapenem-resistant bacteria




Miguela-Villoldo P., Hernandez M., Moreno MA., Rodriguez-Lazaro D., Quesada A., Dominguez L. and Ugarte-Ruiz M..




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Carbapenemase-producing Elizabethkingia meningoseptica from healthy pigs associated with colistin use in Spain

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Carbapenemase-producing Elizabethkingia meningoseptica from healthy pigs associated with colistin use in Spain


Participants:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Instituto Tecnológico Agrario de Castilla y LeónLaboratorio de Biología Molecular y Microbiología. Instituto Tecnológico Agrario de Castilla y León (ITACyL).

Universidad de BurgosUnidad de Microbiología. Departamento de Biotecnología y Ciencia de los Alimentos. Universidad de Burgos (UBU).

Universidad de ExtremaduraDepartamento de Bioquímica, Biología Molecular y Genética. Facultad de Veterinaria. Universidad de Extremadura (UNEX).

Universidad de ExtremaduraInstituto Universitario de Biotecnología Ganadera y Cinegética (INBIO G+C). Universidad de Extremadura (UNEX).







Antibiotics
FACTOR YEAR Q
2.921 2018

PMID: 31514353

ISSN: 2079-6382



TITLE: Carbapenemase-producing Elizabethkingia meningoseptica from healthy pigs associated with colistin use in Spain


JOURNAL: Antibiotics-Basel


NUMERACIÓN: 8,146


AÑO: 2019


PUBLISHER: MDPI


AUTHORS: Miguela-Villoldo P., Hernandez M., Moreno MA., Rodriguez-Lazaro D., Quesada A., Dominguez L. and Ugarte-Ruiz M..


VISAVET PARTICIPANTS


First
Pedro Miguela Villoldo
3rd
Miguel Ángel Moreno Romo
6th
Lucas Domínguez Rodríguez
Last
María Ugarte Ruiz

DOI: https://doi.org/ 10.3390/antibiotics8030146


CITE THIS PUBLICATION:

Miguela-Villoldo P., Hernandez M., Moreno MA., Rodriguez-Lazaro D., Quesada A., Dominguez L. and Ugarte-Ruiz M. Carbapenemase-producing Elizabethkingia meningoseptica from healthy pigs associated with colistin use in Spain. Antibiotics. 8,146. 2019. (A). ISSN: 2079-6382. DOI: 10.3390/antibiotics8030146


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