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CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine


May 1st, 2012

Microbiology and Immunology publish this investigation article


A CpG-enriched recombinant plasmid (pUC18-CpG) as an adjuvant of foot-and-mouth disease (FMD) killed vaccine was tested for immunization and vaccination challenge in a porcine model. Our preliminary results had indicated that the recombinant plasmid could enhance the humoral immune response triggered by the traditional oil-adjuvant vaccine after the initial inoculation. A subsequent vaccination-challenge test showed an increased PD(50) (50% protective dose) value. Thus, coadministration of the recombinant plasmid with the oil-adjuvant vaccine helped illicit an immune response earlier than that elicited by the administration of the vaccine alone. Our results showed that pUC18-CpG can be a potent immunoadjuvant for the traditional FMD killed vaccine and can greatly enhance the traditional vaccine`s efficacy when administered in combination with it




Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM..




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CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine

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CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine

Participants:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Institute of Animal Science (IAS). Chinese Academy of Agricultural Sciences (CAAS).

Yangzhou UniversityCollege of Veterinary Medicine. Yangzhou University (YZU).

Xinjiang Tiankang Animal Science Bio-Technology.







Microbiology and Immunology
FACTOR YEAR Q
1.545 2012

NLMID: 7703966

PMID: 22335800

ISSN: 1348-0421



TITLE: CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine


JOURNAL: Microbiol. Immunol.


NUMERACIÓN: 56(5):332-7


AÑO: 2012


PUBLISHER: Wiley-Blackwell Publishing, inc


AUTHORS: Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: http://dx.doi.org/ 10.1111/j.1348-0421.2012.00438.x


CITE THIS PUBLICATION:

Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM. CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine. Microbiology and Immunology. 56(5):332-7. 2012. ISSN: 1348-0421. DOI: 10.1111/j.1348-0421.2012.00438.x


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