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High Frequency of Detection of NDM-Producing Enterobacterales Among Companion Animals Hospitalized in an Italian Veterinary Teaching Hospital

Investigation article published in Transboundary and Emerging Diseases

In Press

Carbapenems are considered one of the most important last-resort classes of antibiotics, and the spread of carbapenem-resistant Enterobacterales (CRE) is a serious concern worldwide. From a One Health point of view, reports on CRE in companion animals are increasing, requiring attention regarding their role in maintenance and direct transmission to humans. The aim of this study was to assess the frequency of detection at admission and the in-hospital acquisition of CRE from perirectal swabs in dogs and cats hospitalized in an Italian Veterinary Teaching Hospital (VTH). Of the 150 patients sampled, 11.3% (n = 17) were CRE carriers at admission, 25.6% (n = 34) acquired CRE in their commensal microbiota during their hospital stay, and 2% (n = 3) developed an infection caused by CRE. Genotypical analysis showed that in 100% (78/78) of the CRE isolates (44 Escherichia coli, 33 Klebsiella pneumoniae, and 1 Klebsiella aerogenes) carbapenem resistance was conferred by the carbapenemase gene blaNDM, suggesting an endemic presence of such gene within the hospital. Co-occurrent β-lactamase-encoding genes were found in most of the isolates. Risk factors associated with CRE acquisition were length of hospitalization (p = 0.0002) and treatment with piperacillin–tazobactam (PTZ; p = 0.0380), indicating potential cross-selection of CRE. These results reinforce the suspicion that companion animals could silently contribute to the maintenance and dissemination of CRE in the local community, posing a threat to global health




Scarpellini R., Pulido-Vadillo M., Serna C., Gonzalez-Zorn B., Blanco JL., Delgado-Blas JF., Giunti M. and Piva S.




See this article
High Frequency of Detection of NDM-Producing Enterobacterales Among Companion Animals Hospitalized in an Italian Veterinary Teaching Hospital





Participants:

Department of Veterinary Medical Sciences. Università di Bologna (UNIBO).

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseHospital Clínico Veterinario Complutense (HCVC). Universidad Complutense (UCM).

Institut PasteurBiodiversity and Epidemiology of Bacterial Pathogens. Département de Microbiologie. Institut Pasteur.



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Transboundary and Emerging Diseases
FACTOR YEAR Q
3.500 2023

NLMID: 101319538

ISSN: 1865-1674



TITLE: High Frequency of Detection of NDM-Producing Enterobacterales Among Companion Animals Hospitalized in an Italian Veterinary Teaching Hospital


JOURNAL: Transbound Emerg Dis


PUBLISHER: Wiley


AUTHORS: Scarpellini R., Pulido-Vadillo M., Serna C., Gonzalez-Zorn B., Blanco JL., Delgado-Blas JF., Giunti M. and Piva S.


2nd
Mario Pulido Vadillo
4th
Bruno González Zorn
5th
José Luis Blanco Cancelo

DOI: https://doi.org/10.1155/tbed/2622185


CITE THIS PUBLICATION:

Scarpellini R., Pulido-Vadillo M., Serna C., Gonzalez-Zorn B., Blanco JL., Delgado-Blas JF., Giunti M. and Piva S. High Frequency of Detection of NDM-Producing Enterobacterales Among Companion Animals Hospitalized in an Italian Veterinary Teaching Hospital. Transboundary and Emerging Diseases. In Press. (A). ISSN: 1865-1674. DOI: 10.1155/tbed/2622185


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