Oral communication in 7th Congress of the European Association of Veterinary Laboratory Diagnosticians

October 21^st, 2024

Velasco-Reinaldos C., Roy A., Gómez-Buendía A., Alvarez J., Boniotti MB., Dominguez M., Gormley E., Jones G., Martucciello A., Mazzone P., Moreno I., de Juan L., Dominguez L., Romero B. and Bezos J.

Caprine tuberculosis (TB) poses a threat to public and animal health. TB ante-mortem diagnosis primarily utilizes cell-based techniques such as the skin test and the interferon-gamma release assay (IGRA). However, the sensitivity and specificity of both techniques is limited due to, among other factors, the use of Purified Protein Derivatives (PPDs) as reagents. PPDs are poorly characterized and share antigens with non-tuberculous mycobacteria, limiting the specificity of TB diagnostic techniques . In this sense, the aim of the present study was to evaluate more specific reagents (DST-F fusion protein and the P22 protein complex) using cell-based and humoral TB diagnostic techniques in a TB infected setting under field conditions

	Servicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna (IZSLER).
	Servicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).
	UCD School of Agriculture, Food Science & Veterinary Medicine. University College Dublin (UCD).
	TB Immunology and Vaccinology. Department of Bacteriology. Animal and Plant Health Agency (APHA).
	Istituto Zooprofilattico Sperimentale de Mezzogiorno (IZSM).
	Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche (IZSUM).