Investigation article published in The Veterinary Journal

June 1^st, 2015

It has been suggested that infection with Corynebacterium pseudotuberculosis, the pathogen responsible for caseous lymphadenitis (CLA), might interfere with diagnostic testing for tuberculosis (TB), due to antigenic similarities between this particular type of bacterium and those expressed by mycobacteria. The aim of the present study was to investigate whether experimental infection with C. pseudotuberculosis in goats impacted on TB testing, using single and comparative intradermal tuberculin (SIT and SCIT respectively) tests and interferon (IFN)-γ assay. No positive reactors were detected among the CLAaffected goats using the SIT/SCIT tests or the interferon IFN-γ assay. A proportion of goats showed inconclusive results to the SIT test and reactions to Mycobacterium avium. There was no evidence that infection with C. pseudotuberculosis interferes with diagnostic testing for TB using standard interpretation of the SIT, SCIT and IFN-γ tests

Bezos J., Casal C., Romero B., Liandris E., Sanchez-Coppel N., Vigo V., Dominguez L. and de Juan L..

Lack of interference with diagnostic testing for tuberculosis in goats experimentally exposed to Corynebacterium pseudotuberculosis

Lack of interference with diagnostic testing for tuberculosis in goats experimentally exposed to Corynebacterium pseudotuberculosis

	MAEVA SERVET, S.L..
	Servicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Servicio de Sanidad Animal y Laboratorio. Gobierno de Canarias.
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).