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Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health

Investigation article published in The Journal of Antimicrobial Chemotherapy

August 1st, 2014

Pleuromutilins (tiamulin and valnemulin) are antimicrobial agents that are used mainly in veterinary medicine, especially for swine and to a lesser extent for poultry and rabbits. In pigs, tiamulin and valnemulin are used to treat swine dysentery, spirochaete-associated diarrhoea, porcine proliferative enteropathy, enzootic pneumonia and other infections where Mycoplasma is involved. There are concerns about the reported increases in the MICs of tiamulin and valnemulin for porcine Brachyspira hyodysenteriae isolates from different European countries, as only a limited number of antimicrobials are available for the treatment of swine dysentery where resistance to these antimicrobials is already common and widespread. The loss of pleuromutilins as effective tools to treat swine dysentery because of further increases in resistance or as a consequence of restrictions would present a considerable threat to pig health, welfare and productivity. In humans, only one product containing pleuromutilins (retapamulin) is authorized currently for topical use; however, products for oral and intravenous administration to humans with serious multidrug-resistant skin infections and respiratory infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA), are being developed. The objective of this review is to summarize the current knowledge on the usage of pleuromutilins, resistance development and the potential impact of this resistance on animal and human health




van Duijkeren E., Greko C., Pringle M., Baptiste K., Catry B., Jukes H., Moreno MA., Matias-Ferreira MC., Pyorala S., Rantala M., Ruzauskas M., Sanders P., Teale C., Threlfall EJ., Torren-Edo J. and Torneke K.




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Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health

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Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health


Participants:

Ministry of Health, Welfare and Sport. Government of the NetherlandsNational Institute for Public Health and the Environment (RIVM). Ministry of Health, Welfare and Sport. Government of the Netherlands.

Danish Health and Medicines Agency.

Scientific Institute of Public Health, Epidemiology Unit. European Programme for Intervention Epidemiology Training (EPIET).

Veterinary Medicines Directorate (VMD).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Zoonosis de Transmisi鏮 Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Faculdade de Medicina Veterin嫫ia. Universidade T嶰nica de Lisboa (UTL).

Faculty of Veterinary Medicine. University of Helsinki.

Veterinary Academy. Lithuanian University of Health Sciences (LSMU).


Department for Environment, Food and Rural AffairsVeterinary Laboratories Agency. Department for Environment, Food and Rural Affairs (Defra).

Health Protection Agency Microbiology Services Colindale London.

European Medicines Agency (EMEA).

L鄢emedelsverket Medical Products Agency.







The Journal of Antimicrobial Chemotherapy
FACTOR YEAR Q
5.313 2014

NLMID: 7513617

PMID: 24793902

ISSN: 0305-7453



TITLE: Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health


JOURNAL: J. Antimicrob. Chemother.


NUMERACIÓN: 69(8):2022-31.


AÑO: 2014


PUBLISHER: Oxford University Press


AUTHORS: van Duijkeren E., Greko C., Pringle M., Baptiste K., Catry B., Jukes H., Moreno MA., Matias-Ferreira MC., Pyorala S., Rantala M., Ruzauskas M., Sanders P., Teale C., Threlfall EJ., Torren-Edo J. and Torneke K.


VISAVET PARTICIPANTS


Miguel 聲gel Moreno Romo

DOI: https://doi.org/ 10.1093/jac/dku123


CITE THIS PUBLICATION:

van Duijkeren E., Greko C., Pringle M., Baptiste K., Catry B., Jukes H., Moreno MA., Matias-Ferreira MC., Pyorala S., Rantala M., Ruzauskas M., Sanders P., Teale C., Threlfall EJ., Torren-Edo J. and Torneke K. Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health. The Journal of Antimicrobial Chemotherapy. 69(8):2022-31.. 2014. (A). ISSN: 0305-7453. DOI: 10.1093/jac/dku123


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