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Prevalence and trend analysis of antimicrobial resistance in clinical Escherichia coli isolates collected from diseased pigs in the USA between 2006 and 2016

Transboundary and Emerging Diseases publish this investigation article

February 25th, 2020

Antimicrobial resistance (AMR) is an emerging threat to both human and animal health. Antimicrobial use and resistance in food animal production including swine has received increased scrutiny as a source of resistant foodborne pathogens. Continuous surveillance of AMR in bacterial isolates of swine origin can guide in conservation of antimicrobials used in both human and swine medicine. The objective of this study was to evaluate the prevalence and trends of the phenotypic AMR in Escherichia coli of swine origin isolated from clinical samples at the Minnesota Veterinary Diagnostic laboratory between 2006‐2016. The prevalence of resistance to ampicillin, tetracyclines and sulphadimethoxine remained greater than 50% throughout the period. There was a drastic change in enrofloxacin resistance, increasing from less than 1% to more than 20% between 2006‐2016 (annual relative increase of 57% between 2006‐13 and 16% between 2013‐16). The prevalence of resistance to other antimicrobials remained constant (ceftiofur, oxytetracycline, chlortetracycline) or changed significantly (annual relative changes of less than 10%) for at least some time‐period between 2006‐16 (ampicillin, florfenicol, gentamicin, neomycin, sulphadimethoxine, trimethoprim‐sulphamethoxazole, spectinomycin). Rarefaction analysis revealed an increase in the number of unique combinations of AMRs per year. Network analysis was performed by estimating and plotting partial correlations between minimum inhibitory concentrations of various antimicrobials. An increase in strength of these networks was observed, particularly in networks created for years later than 2010 which can be indicative of increased multiple antimicrobial resistance in these isolates. These results provide valuable insight into the trends in AMR in E. coli of swine origin in USA and act as supplementary information to existing active AMR surveillance systems




Hayer SS., Rovira A., Olsen K., Johnson TJ., Vannucci F., Rendahl A., Perez A. and Alvarez J..




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Prevalence and trend analysis of antimicrobial resistance in clinical Escherichia coli isolates collected from diseased pigs in the USA between 2006 and 2016

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Prevalence and trend analysis of antimicrobial resistance in clinical Escherichia coli isolates collected from diseased pigs in the USA between 2006 and 2016


Participants:

University of MinnesotaDepartment of Veterinary Population Medicine. Veterinary Diagnostic Laboratory. Department of Veterinary and Biomedical Sciences. College of Veterinary Medicine. University of Minnesota (UMM).

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Transboundary and Emerging Diseases
FACTOR YEAR Q
3.554 2018

NLMID: 101319538

PMID: 32097517

ISSN: 1865-1674



TITLE: Prevalence and trend analysis of antimicrobial resistance in clinical Escherichia coli isolates collected from diseased pigs in the USA between 2006 and 2016


JOURNAL: Transbound. Emerg. Dis.


AÑO: 2020


PUBLISHER: Blackwell Verlag


AUTHORS: Hayer SS., Rovira A., Olsen K., Johnson TJ., Vannucci F., Rendahl A., Perez A. and Alvarez J..


VISAVET PARTICIPANTS


Julio Álvarez Sánchez

DOI: https://doi.org/ 10.1111/tbed.13528


CITE THIS PUBLICATION:

Hayer SS., Rovira A., Olsen K., Johnson TJ., Vannucci F., Rendahl A., Perez A. and Alvarez J. Prevalence and trend analysis of antimicrobial resistance in clinical Escherichia coli isolates collected from diseased pigs in the USA between 2006 and 2016. Transboundary and Emerging Diseases. 2020. (A). ISSN: 1865-1674. DOI: 10.1111/tbed.13528