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SatR is a repressor of fluoroquinolone efflux pump SatAB

Investigation article published in Antimicrobial Agents and Chemotherapy

July 1st, 2013

Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here we describe and characterize satR, an ORF encoding a MarR-superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB and its interruption entails the overexpression of the pump, leading to a clinically-relevant increase in resistance to fluoroquinolones




Escudero JA., San Millan A., Montero N., Gutierrez B., Ovejero CM., Carrilero L. and Gonzalez-Zorn B..




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SatR is a repressor of fluoroquinolone efflux pump SatAB

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SatR is a repressor of fluoroquinolone efflux pump SatAB


Participants:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Antimicrobial Agents and Chemotherapy
FACTOR YEAR Q
4.451 2013

NLMID: 315061

PMID: 23650171

ISSN: 0066-4804



TITLE: SatR is a repressor of fluoroquinolone efflux pump SatAB


JOURNAL: Antimicrob. Agents Chemother.


NUMERACIÓN: 57(7):3430-3


AÑO: 2013


PUBLISHER: American Society for Microbiology


AUTHORS: Escudero JA., San Millan A., Montero N., Gutierrez B., Ovejero CM., Carrilero L. and Gonzalez-Zorn B..


VISAVET PARTICIPANTS


First
José Antonio Escudero García-Calderón
Last
Bruno González Zorn

DOI: https://doi.org/ 10.1128/AAC.00515-13


CITE THIS PUBLICATION:

Escudero JA., San Millan A., Montero N., Gutierrez B., Ovejero CM., Carrilero L. and Gonzalez-Zorn B. SatR is a repressor of fluoroquinolone efflux pump SatAB. Antimicrobial Agents and Chemotherapy. 57(7):3430-3. 2013. (A). ISSN: 0066-4804. DOI: 10.1128/AAC.00515-13


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