Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
Nutrients publish this investigation article
November 7th, 2019
This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, amino acids, fat, fatty acids, fiber, simple sugars and micronutrients were analyzed. For the first time, toxicological and physiological effects were evaluated in vivo by a repeated-dose study in healthy Wistar rats. Hormone secretion, antioxidant (enzymatic and no-enzymatic) and anti-inflammatory biomarkers, and dietary fiber fermentability of CSE (analysis of SCFAs in feces) were studied in biological samples. This unique research confirms the feasibility of CSE as a human dietary supplement with several nutrition claims: "source of proteins (16%), potassium, magnesium, calcium and vitamin C, low in fat (0.44%) and high in fiber (22%)". This is the first report demonstrating that its oral administration (1 g/kg) for 28 days is innocuous. Hormone secretion, antioxidant or anti-inflammatory biomarkers were not affected in heathy animals. Total SCFAs derived from CSE fiber fermentation were significantly higher (p < 0.05) in male treated rats compared to male control rats. All the new information pinpoints CSE as a natural, sustainable and safe food ingredient containing fermentable fiber able to produce SCFAs with beneficial effects on gut microbiota
Iriondo-Dehond A., Rios MB., Herrera T., Rodriguez-Bertos A., Nunez F., San Andres MI., Sanchez-Fortun S. and del Castillo MD.
 | Instituto de Investigación en Ciencias de la Alimentación (CIAL). Universidad Autónoma de Madrid (UAM). |
 | Servicio de Patología y Veterinaria Forense (SAP). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Departamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
 | Centro de Biología Molecular Severo Ochoa (CBMSO). Consejo Superior de Investigaciones Científicas (CSIC). Universidad Autónoma de Madrid (UAM). |
