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The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and cointegrate formation in vivo

Antimicrobial Agents and Chemotherapy publish this investigation article

July 25th, 2019

In 2012, a carbapenemase-producing Salmonella (S.) Corvallis carrying a bla NDM-1 multi-resistance IncA/C2 plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In recent broiler chicken infection study, we observed transfer of this bla NDM-1-carrying IncA/C2 plasmid to other Enterobacteriaceae Here, we focused on the stability of this plasmid and gained insight into type and frequency of its structural alterations after an in vivo passage in a broiler infection study




Hadziabdic S., Fischer J., Borowiak M., Malorny B., Juraschek K., Kasbohrer A., Guerra B., Deneke C., Gonzalez-Zorn B. and Szabo I.




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The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and cointegrate formation in vivo

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The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and cointegrate formation in vivo



Participants:

Federal Institute for Risk AssessmentDepartment of Biological Safety. Federal Institute for Risk Assessment (BfR).

European Food Safety AuthorityEuropean Food Safety Authority (EFSA).

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Antimicrobial Agents and Chemotherapy
FACTOR YEAR Q
4.904 2019

NLMID: 315061

PMID: 31109975

ISSN: 0066-4804



TITLE: The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and cointegrate formation in vivo


JOURNAL: Antimicrob Agents Chemother


NUMERACIÓN: 63(8):e00380-19


AÑO: 2019


PUBLISHER: American Society for Microbiology


AUTHORS: Hadziabdic S., Fischer J., Borowiak M., Malorny B., Juraschek K., Kasbohrer A., Guerra B., Deneke C., Gonzalez-Zorn B. and Szabo I.


Bruno González Zorn

DOI: https://doi.org/10.1128/AAC.00380-19


CITE THIS PUBLICATION:

Hadziabdic S., Fischer J., Borowiak M., Malorny B., Juraschek K., Kasbohrer A., Guerra B., Deneke C., Gonzalez-Zorn B. and Szabo I. The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and cointegrate formation in vivo. Antimicrobial Agents and Chemotherapy. 63(8):e00380-19. 2019. (A). ISSN: 0066-4804. DOI: 10.1128/AAC.00380-19