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The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and co-integrate formation in vivo

Antimicrobial Agents and Chemotherapy publish this investigation article

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In 2012, a carbapenemase-producing Salmonella (S.) Corvallis carrying a bla NDM-1 multi-resistance IncA/C2 plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In recent broiler chicken infection study, we observed transfer of this bla NDM-1-carrying IncA/C2 plasmid to other Enterobacteriaceae Here, we focused on the stability of this plasmid and gained insight into type and frequency of its structural alterations after an in vivo passage in a broiler infection study




Hadziabdic S., Fischer J., Borowiak M., Malorny B., Juraschek K., Kasbohrer A., Guerra B., Deneke C., Gonzalez-Zorn B. and Szabo I.




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The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and co-integrate formation in vivo

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The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and co-integrate formation in vivo

Participants:

Federal Institute for Risk AssessmentDepartment of Biological Safety. Federal Institute for Risk Assessment (BfR).

European Food Safety AuthorityEuropean Food Safety Authority (EFSA).

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Antimicrobial Agents and Chemotherapy
FACTOR YEAR Q
4.715 2018

NLMID: 315061

PMID: 31109975

ISSN: 0066-4804



TITLE: The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and co-integrate formation in vivo


JOURNAL: Antimicrob. Agents Chemother.


PUBLISHER: American Society for Microbiology


AUTHORS: Hadziabdic S., Fischer J., Borowiak M., Malorny B., Juraschek K., Kasbohrer A., Guerra B., Deneke C., Gonzalez-Zorn B. and Szabo I.


VISAVET PARTICIPANTS


Bruno González Zorn

DOI: https://doi.org/ 10.1128/AAC.00380-19


CITE THIS PUBLICATION:

Hadziabdic S., Fischer J., Borowiak M., Malorny B., Juraschek K., Kasbohrer A., Guerra B., Deneke C., Gonzalez-Zorn B. and Szabo I. The bla NDM-1 carrying IncA/C2 plasmid underlies structural alterations and co-integrate formation in vivo. Antimicrobial Agents and Chemotherapy. In Press. (A). ISSN: 0066-4804. DOI: 10.1128/AAC.00380-19