Inicio \ Divulgación \ Artículos de divulgación \


Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries


3 de agosto de 2018

Munk P., Knudsen BE., Lukjacenko O., Ribeiro Duarte AS., Van Gompel L., Luiken REC., Smit LAM., Schmitt H., Dorado Garcia A., Borup Hansen R., Nordahl Petersen T., Bossers A., Ruppe E., EFFORT Group., Lund O., Hald T., Pamp SJ., Vigre H., Heederik D., Wagenaar J., Mevius D. y Aarestrup FM.

Artículo de divulgación publicado en Nature microbiology


EFFORT Group
Haitske Graveland2 , Alieda van Essen4, Bruno Gonzalez-Zorn8, Gabriel Moyano8, Pascal Sanders9, Claire Chauvin9, Julie David9, Antonio Battisti10, Andrea Caprioli10, Jeroen Dewulf11, Thomas Blaha12, Katharina Wadepohl12, Maximiliane Brandt12, Dariusz Wasyl13, Magdalena Skarzyńska13, Magdalena Zajac13, Hristo Daskalov14, Helmut W. Saatkamp4 and Katharina D. C. Stärk15
Antimicrobial resistance (AMR) in bacteria and associated human morbidity and mortality is increasing. The use of antimicrobials in livestock selects for AMR that can subsequently be transferred to humans. This flow of AMR between reservoirs demands
surveillance in livestock and in humans. We quantified and characterized the acquired resistance gene pools (resistomes) of 181 pig and 178 poultry farms from nine European countries, sequencing more than 5,000 Gb of DNA using shotgun metagenomics. We quantified acquired AMR using the ResFinder database and a second database constructed for this study, consisting of AMR genes identified through screening environmental DNA. The pig and poultry resistomes were very different in abundance and composition. There was a significant country effect on the resistomes, more so in pigs than in poultry. We found higher AMR loads in pigs, whereas poultry resistomes were more diverse. We detected several recently described, critical AMR genes, including mcr-1 and optrA, the abundance of which differed both between host species and between countries. We found that the total acquired AMR level was associated with the overall country-specific antimicrobial usage in livestock and that countries with comparable usage patterns had similar resistomes. However, functionally determined AMR genes were not associated with total drug use





Ver artículo
Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries

Enlace relacionado: Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries

Participantes:

Technical University of DenmarkResearch Group for Genomic Epidemiology. National Food Institute (DTU Food). Technical University of Denmark (DTU).

Utrecht UniversityInstitute for Risk Assessment Sciences. Utrecht University (UU).

INTOMICS AS.

Wageningen Bioveterinary Research.

Genomic Research Laboratory. Hôpitaux Universitaires de Genève.

Utrecht UniversityDepartment of Infectious Diseases and Immunology. Faculty of Veterinary Medicine. Utrecht University (UU).

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).








TÍTULO: Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries


TIPO: Artículo de divulgación


AUTORES: Munk P., Knudsen BE., Lukjacenko O., Ribeiro Duarte AS., Van Gompel L., Luiken REC., Smit LAM., Schmitt H., Dorado Garcia A., Borup Hansen R., Nordahl Petersen T., Bossers A., Ruppe E., EFFORT Group., Lund O., Hald T., Pamp SJ., Vigre H., Heederik D., Wagenaar J., Mevius D. y Aarestrup FM.


REVISTA: Nature microbiology


IDIOMA: Inglés


NUMERACIÓN: 3(8):898-908(2018)


FECHA: 3 de agosto de 2018


EDITORIAL: Springer Nature Limited


DOI: https://doi.org/10.1038/s41564-018-0192-9


CITA ESTA PUBLICACIÓN:

Munk P., Knudsen BE., Lukjacenko O., Ribeiro Duarte AS., Van Gompel L., Luiken REC., Smit LAM., Schmitt H., Dorado Garcia A., Borup Hansen R., Nordahl Petersen T., Bossers A., Ruppe E., EFFORT Group., Lund O., Hald T., Pamp SJ., Vigre H., Heederik D., Wagenaar J., Mevius D. y Aarestrup FM. Abundance and diversity of the faecal resistome in slaughter pigs and broilers in nine European countries. Nature microbiology. 3(8):898-908(2018). Springer Nature Limited. 2018. (Artículo de divulgación)


SERVICIOS: