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Antimicrobial susceptibility of Trueperella pyogenes isolated from food-producing ruminants

Investigación publicada en Veterinary Microbiology

1 de marzo de 2020

A total of 96 Trueperella pyogenes isolates, an opportunistic pathogen of food-producing ruminants, obtained from cattle (n = 34), sheep (n = 35) and goats (n = 27), and identified by Real Time PCR (qPCR), were analysed to determine the susceptibility to 12 antimicrobials commonly used in livestock, using a broth microdilution. The Minimal Inhibitory Concentration (MIC) distribution was unimodal for half of the antimicrobials tested with the exception of apramycin, gentamicin, streptomycin, oxytetracycline, tylosin, and erythromycin all of which showed bimodal MIC distributions. Low MIC90 values for penicillin, amoxicillin, ceftiofur, enrofloxacin, and gentamicin (<1 μg/ml) were obtained, suggesting that these antimicrobials would be the most effective first line empiric treatment for T. pyogenes infections in livestock. Furthermore, according to the specific T. pyogenes breakpoints for penicillin, sulfamethoxazole/trimethoprim and erythromycin, 93.7 % of isolates were susceptible to penicillin and 77.2 % to erythromycin, whereas 92.7 % were non-susceptible to sulfamethoxazole/trimethoprim. Significant differences were observed in the MIC distribution of almost all antimicrobials, except enrofloxacin, tylosin and erythromycin against cattle, sheep or goat isolates, although all antimicrobials showed similar MIC90 values, except apramycin and oxytetracycline that showed higher values when tested against cattle isolates. These data provide interesting information on the antimicrobials of choice for the treatment of infections caused by T. pyogenes in ruminants




Galan-Relaño A., Gomez-Gascon L., Barrero-Dominguez B., Luque I., Jurado-Martos F., Vela AI., Sanz-Tejero C. y Tarradas C.




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Antimicrobial susceptibility of Trueperella pyogenes isolated from food-producing ruminants




Participantes:

Universidad de CórdobaDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad de Córdoba (UCO).

DCOOP S.CDCOOP S.C.

Universidad ComplutenseServicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Laboratorio ExopolMicrobiology Department. Laboratorio Exopol.







Veterinary Microbiology
FACTOR YEAR Q
2.791 2018

NLMID: 7705469

ISSN: 0378-1135



TÍTULO: Antimicrobial susceptibility of Trueperella pyogenes isolated from food-producing ruminants


REVISTA: Vet. Microbiol.


NUMERACIÓN: 242:108593


AÑO: 2020


EDITORIAL: Elsevier Science Publishers


AUTORES: Galan-Relaño A., Gomez-Gascon L., Barrero-Dominguez B., Luque I., Jurado-Martos F., Vela AI., Sanz-Tejero C. and Tarradas C.


PARTICIPANTES VISAVET


Ana Isabel Vela Alonso

DOI: https://doi.org/10.1016/j.vetmic.2020.108593


CITA ESTA PUBLICACIÓN:

Galan-Relaño A., Gomez-Gascon L., Barrero-Dominguez B., Luque I., Jurado-Martos F., Vela AI., Sanz-Tejero C. y Tarradas C. Antimicrobial susceptibility of Trueperella pyogenes isolated from food-producing ruminants. Veterinary Microbiology. 242:108593. 2020. (A). ISSN: 0378-1135. DOI: 10.1016/j.vetmic.2020.108593


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