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Association of extended spectrum beta-lactamase VEB-5 and 16S rRNAmethyltransferase ArmA in Salmonella enterica from United Kingdom

Investigación publicada en Antimicrobial Agents and Chemotherapy

1 de septiembre de 2012

Aminoglycosides and beta-lactams are used for the treatment of a wide range of infections due to both Gram-negative and Gram-positive. An emerging aminoglycoside resistance mechanism, methylation of the aminoacyl site of the 16S rRNA, confers high-level resistance to clinically important aminoglycosides such as amikacin, tobramycin and gentamicin. Eight 16S rRNA methyltransferase genes, armA, rmtA, rmtB, rmtC, rmtD, rmtE, rmtF and npmA, have been identified in several species of enterobacteria worldwide (2, 6, 7, 9, 11, 13, 14). Resistance to extended spectrum β-lactams remains additionally an important clinical problem. Apart from the large TEM, SHV, and CTX-M families, several other extended-spectrum β-lactamases (ESBLs) have been identified, including VEB enzymes, which confer high-level resistance to cephalosporins and monobactams. Although 16S rRNA methyltransferases have been frequently identified associated with different ESBLs, there has been no report of association of a 16S rRNA methyltransferase with a VEB enzyme, except for the identification of rmtC with blaVEB-6 (14)




Hidalgo L., Hopkins KL., Wareham DW., Gutierrez B. y Gonzalez-Zorn B..




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Association of extended spectrum beta-lactamase VEB-5 and 16S rRNAmethyltransferase ArmA in Salmonella enterica from United Kingdom

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Association of extended spectrum beta-lactamase VEB-5 and 16S rRNAmethyltransferase ArmA in Salmonella enterica from United Kingdom


Participantes:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Health Protection Agency Microbiology Services Colindale London.

Queen Mary University (QMUL).







Antimicrobial Agents and Chemotherapy
FACTOR YEAR Q
4.565 2012

NLMID: 315061

PMID: 22710120

ISSN: 0066-4804



TÍTULO: Association of extended spectrum beta-lactamase VEB-5 and 16S rRNAmethyltransferase ArmA in Salmonella enterica from United Kingdom


REVISTA: Antimicrob. Agents Chemother.


NUMERACIÓN: 56(9):4985-7


AÑO: 2012


EDITORIAL: American Society for Microbiology


AUTORES: Hidalgo L., Hopkins KL., Wareham DW., Gutierrez B. and Gonzalez-Zorn B..


PARTICIPANTES VISAVET


Bruno González Zorn

DOI: https://doi.org/10.1128/AAC.00381-12


CITA ESTA PUBLICACIÓN:

Hidalgo L., Hopkins KL., Wareham DW., Gutierrez B. y Gonzalez-Zorn B. Association of extended spectrum beta-lactamase VEB-5 and 16S rRNAmethyltransferase ArmA in Salmonella enterica from United Kingdom. Antimicrobial Agents and Chemotherapy. 56(9):4985-7. 2012. (A). ISSN: 0066-4804. DOI: 10.1128/AAC.00381-12


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