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Characterization of the immune response induced by a commercially available inactivated Bluetongue virus serotype 1 vaccine in sheep

Scientific World Journal publica este artículo de investigación

1 de abril de 2012

The protective immune response generated by a commercial monovalent inactivated vaccine against bluetongue virus serotype 1 (BTV1) was studied. Five sheep were vaccinated, boost-vaccinated, and then challenged against BTV1 ALG/2006. RT-PCR did not detect viremia at any time during the experiment. Except a temperature increase observed after the initial and boost vaccinations, no clinical signs or lesions were observed. A specific and protective antibody response checked by ELISA was induced after vaccination and boost vaccination. This specific antibody response was associated with a significant increase in B lymphocytes confirmed by flow cytometry, while significant increases were not observed in T lymphocyte subpopulations (CD4+, CD8+, and WC1+), CD25+ regulatory cells, or CD14+ monocytes. After challenge with BTV1, the antibody response was much higher than during the boost vaccination period, and it was associated with a significant increase in B lymphocytes, CD14+ monocytes, CD25+ regulatory cells, and CD8+ cytotoxic T lymphocytes




Perez de Diego AC., Sanchez-Cordon PJ., de las Heras AI. y Sanchez-Vizcaino JM..




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Characterization of the immune response induced by a commercially available inactivated Bluetongue virus serotype 1 vaccine in sheep

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Characterization of the immune response induced by a commercially available inactivated Bluetongue virus serotype 1 vaccine in sheep


Participantes:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







FACTOR YEAR Q
1.730 2012

NLMID: 101131163

PMID: 22619592

ISSN: 1537-744X



TÍTULO: Characterization of the immune response induced by a commercially available inactivated Bluetongue virus serotype 1 vaccine in sheep


REVISTA: Sci. World J.


NUMERACIÓN: 1-8


AÑO: 2012


EDITORIAL: Newbury, Berkshire, UK : TheScientificWorld


AUTORES: Perez de Diego AC., Sanchez-Cordon PJ., de las Heras AI. and Sanchez-Vizcaino JM..


PARTICIPANTES VISAVET


José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.1100/2012/147158


CITA ESTA PUBLICACIÓN:

Perez de Diego AC., Sanchez-Cordon PJ., de las Heras AI. y Sanchez-Vizcaino JM. Characterization of the immune response induced by a commercially available inactivated Bluetongue virus serotype 1 vaccine in sheep. Scientific World Journal . 1-8. 2012. (A). ISSN: 1537-744X. DOI: 10.1100/2012/147158


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