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Comparison of depopulation and S19-RB51 vaccination strategies for control of bovine brucellosis in high prevalence areas

Investigación publicada en The Veterinary Record

21 de junio de 2014

RB51 vaccination can minimize the diagnostic problems associated with S19 vaccination of adult cattle, but its use for bovine brucellosis (BB) control remains controversial. Here, we describe the evolution of BB prevalence in five high- revalence areas in Spain subjected to different control measures: herd-depopulation of infected herds (I-III) or mass vaccination with RB51 and S19/RB51 vaccination of replacement heifers (IV-V). Annual data from the eradication campaigns was analyzed at a Special Incidence Area (SIA) level and the time to obtain herd-prevalence levels of<1% (“control status”) was obtained at the Local Veterinary Unit (LVU) level and compared using a Cox’s proportional-hazard models. A higher annual rate of decrease of the herd prevalence was observed in the SIAs subjected to vaccination (46.9%, 95% Confidence Interval 43.5-50.0) compared to those managed using stamping out (14.9%, 95% CI 9.6-19.9). No significant differences on the time to achieve a control status were observed depending on the stamping- ut/vaccination strategy used at the LVU level, with a median time of 60 (stamping-out LVUs) and 63 (vaccination LVUs) months. Our results suggest that RB51 mass vaccination, in combination with the S19/RB51 vaccination of replacement heifers and strict implementation of other eradication measures, may provide results at least comparable to those expected when a herd depopulation based strategy is implemented




Saez-Llorente JL., Sanz C., Duran M., Garcia P., Fernandez F., Minguez O., Carbajo L., Mardones FO., Perez AM., Gonzalez S., Dominguez L. y Alvarez J..




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Comparison of depopulation and S19-RB51 vaccination strategies for control of bovine brucellosis in high prevalence areas

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Comparison of depopulation and S19-RB51 vaccination strategies for control of bovine brucellosis in high prevalence areas


Participantes:

Ministerio de Agricultura, Alimentación y Medio AmbienteSubdirección General de Sanidad e Higiene Animal y Trazabilidad. Dirección General de Sanidad de la Producción Agraria. Ministerio de Agricultura, Alimentación y Medio Ambiente (MAGRAMA).

Ministerio de Agricultura, Alimentación y Medio AmbienteLaboratorio Central de Sanidad Animal (LCSA). Área de Ganadería. Ministerio de Agricultura, Alimentación y Medio Ambiente (MAGRAMA).

Gobierno de Castilla-La ManchaConsejeria de Agricultura y Medio Ambiente. Gobierno de Castilla-La Mancha (JCCM).

Gobierno de CantabriaConsejería de Desarrollo Rural, Ganadería, Pesca y Biodiversidad. Gobierno de Cantabria.

Junta de Castilla y LeónServicio de Sanidad Animal. Junta de Castilla y León.

University of California-DavisUniversity of California-Davis (UCDAVIS).

University of MinnesotaCollege of Veterinary Medicine. University of Minnesota (UMM).

Universidad ComplutenseServicio de Zoonosis Emergentes, de Baja Prevalencia y Agresivos Biológicos (NED). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Comunidad de MadridInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS). Universidad Complutense (UCM). Universidad Autónoma de Madrid (UAM). Universidad de Alcalá (UAH). Salud Madrid. Comunidad de Madrid.







The Veterinary Record
FACTOR YEAR Q
1.493 2014

NLMID: 31164

PMID: 24836427

ISSN: 0042-4900



TÍTULO: Comparison of depopulation and S19-RB51 vaccination strategies for control of bovine brucellosis in high prevalence areas


REVISTA: Vet. Rec.


NUMERACIÓN: 174(25):634


AÑO: 2014


EDITORIAL: British Veterinary Medicine


AUTORES: Saez-Llorente JL., Sanz C., Duran M., Garcia P., Fernandez F., Minguez O., Carbajo L., Mardones FO., Perez AM., Gonzalez S., Dominguez L. and Alvarez J..


PARTICIPANTES VISAVET


10th
Sergio González Domínguez
11th
Lucas Domínguez Rodríguez
Last
Julio Álvarez Sánchez

DOI: https://doi.org/10.1136/vr.101979


CITA ESTA PUBLICACIÓN:

Saez-Llorente JL., Sanz C., Duran M., Garcia P., Fernandez F., Minguez O., Carbajo L., Mardones FO., Perez AM., Gonzalez S., Dominguez L. y Alvarez J. Comparison of depopulation and S19-RB51 vaccination strategies for control of bovine brucellosis in high prevalence areas. The Veterinary Record. 174(25):634. 2014. (A). ISSN: 0042-4900. DOI: 10.1136/vr.101979


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