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Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis

Veterinary Research publica este artículo de investigación

15 de octubre de 2019

Effective vaccines against tuberculosis (TB) are needed in order to prevent TB transmission in human and animal populations. Evaluation of TB vaccines may be facilitated by using reliable animal models that mimic host pathophysiology and natural transmission of the disease as closely as possible. In this study, we evaluated the immunogenicity and efficacy of two attenuated vaccines, BCG and MTBVAC, after each was given to 17 goats (2 months old) and then exposed for 9 months to goats infected with M. caprae. In general, MTBVAC-vaccinated goats showed higher interferon-gamma release than BCG vaccinated goats in response to bovine protein purified derivative and ESAT-6/CFP-10 antigens and the response was significantly higher than that observed in the control group until challenge. All animals showed lesions consistent with TB at the end of the study. Goats that received either vaccine showed significantly lower scores for pulmonary lymph nodes and total lesions than unvaccinated controls. Both MTBVAC and BCG vaccines proved to be immunogenic and effective in reducing severity of TB pathology caused by M. caprae. Our model system of natural TB transmission may be useful for evaluating and optimizing vaccines




Roy A., Tome-Sanchez I., Romero B., Lorente-Leal V., Infantes-Lorenzo JA., Dominguez M., Martin C., Aguilo N., Puentes E., Rodriguez E., de Juan L., Risalde MA., Gortazar C., Dominguez L. y Bezos J..




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Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis




Participantes:

BIOFABRI, S.L.BIOFABRI, S.L..

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Instituto de Salud Carlos IIICentro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).

Universidad de ZaragozaDepartamento de Microbiología, Medicina Preventiva y Salud Pública. Facultad de Medicina. Universidad de Zaragoza (UNIZAR).

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Instituto de Salud Carlos III (ISCIII).

Hospital Universitario Miguel ServetServicio de Microbiología. Hospital Universitario Miguel Servet.

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad de CórdobaDepartamento de Anatomía y Anatomía Patológica Comparadas. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Instituto Maimonides de Investigación Biomédica de CordobaUnidad de Enfermedades Infecciosas. Hospital Universitario Reina Sofía de Córdoba. Instituto Maimonides de Investigación Biomédica de Cordoba.

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Universidad ComplutenseServicio de Ensayos Clínicos (SEC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







Veterinary Research
FACTOR YEAR Q
3.117 2018

NLMID: 9309551

ISSN: 0928-4249



TÍTULO: Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis


REVISTA: Vet. Res.


NUMERACIÓN: 50:82


AÑO: 2019


EDITORIAL: BMC


AUTORES: Roy A., Tome-Sanchez I., Romero B., Lorente-Leal V., Infantes-Lorenzo JA., Dominguez M., Martin C., Aguilo N., Puentes E., Rodriguez E., de Juan L., Risalde MA., Gortazar C., Dominguez L. and Bezos J..


PARTICIPANTES VISAVET


3rd
Beatriz Romero Martínez
4th
Victor Lorente Leal
11th
Lucía de Juan Ferré
14th
Lucas Domínguez Rodríguez
Last
Javier Bezos Garrido

DOI: https://doi.org/10.1186/s13567-019-0702-7


CITA ESTA PUBLICACIÓN:

Roy A., Tome-Sanchez I., Romero B., Lorente-Leal V., Infantes-Lorenzo JA., Dominguez M., Martin C., Aguilo N., Puentes E., Rodriguez E., de Juan L., Risalde MA., Gortazar C., Dominguez L. y Bezos J. Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis. Veterinary Research. 50:82. 2019. (A). ISSN: 0928-4249. DOI: 10.1186/s13567-019-0702-7


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