Improving the diagnosis of tuberculosis in domestic ruminants through the use of new antigens and test platforms. The imdiTBap project
Artículo de divulgación publicado en EAVLD Newsletter
1 de junio de 2025
Velasco-Reinaldos C., Ortega J., Roy A., Moreno I., Dominguez M., Jones G., Gormley E., McGill K., Boniotti MB., Bakker D., Or E., Mazzone P., Martucciello A . y Bezos J..
The impact of zoonotic tuberculosis (TB) has been known for a long time, leading to the implementation of milk pasteurization as a key preventive measure. Livestock TB control programs were originally designed to reduce the risk posed by zoonotic transmission to humans. Diagnosis of TB in livestock is based primarily on cell-mediated immunity (CMI) diagnostic tests (intradermal test/IT and interferon-gamma release assay/IGRA) using PPDs (purified protein derivatives from Mycobacterium bovis and M. avium) that are sub-optimal in terms of sensitivity (Se) and specificity (Sp). Therefore, there is a need to continue working on the development and improvement of diagnostic techniques based on CMI and humoral response
 | Servicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
 | Servicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII). |
 | Department of Bacteriology. Animal and Plant Health Agency (APHA). |
 | University College Dublin (UCD). |
| Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER). | |
| Istanbul University-Cerrahpasa. | |
| Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche (IZSUM). | |
| National Reference Centre for Hygiene and Technologies of Water Buffalo Farming and Production (CReNBuf). Istituto Zooprofilattico Sperimentale de Mezzogiorno (IZSM). | |
