Genomic and Pathogenic Investigations of Streptococcus suis Serotype 7 Population derived from a Human Patient and Pigs
Investigación publicada en Emerging microbes and infections
1 de diciembre de 2021
Streptococcus suis is one of the important emerging zoonotic pathogens. Serotype 2 is most prevalent in patients worldwide. In the present study, we first isolated one S. suis serotype 7 strain GX69 from the blood culture of a patient with septicemia complicated with pneumonia in China. In order to deepen the understanding of S. suis serotype 7 population characteristics, we investigated the phylogenetic structure, genomic features, and virulence of S. suis serotype 7 population, including 35 strains and 79 genomes. Significant diversities were revealed in S. suis serotype 7 population, which were clustered into 22 sequence types (STs), five minimum core genome (MCG) groups, and six lineages. Lineages 1, 3a, and 6 were mainly constituted by genomes from Asia. Genomes of Lineages 2, 3b, and 5a were mainly from Northern America. Most of genomes from Europe (41/48) were clustered into Lineage 5b. In addition to strain GX69, 13 of 21 S. suis serotype 7 representative strains were classified as virulent strains using the C57BL/6 mouse model. Virulence-associated genes preferentially present in highly pathogenic S. suis serotype 2 strains were not suitable as virulence indicators for S. suis serotype 7 strains. Integrative mobilizable elements were widespread and may play a critical role in disseminating antibiotic resistance genes of S. suis serotype 7 strains. Our study confirmed S. suis serotype 7 is a non-negligible pathotype and deepened the understanding of the population structure of S. suis serotype 7, which provided valuable information for the improved surveillance of this serotype
Liang P., Wang M., Gottschalk M., Vela AI., Estrada AA., Wang J., Du P., Luo M., Wu Z. y Zheng H.
| Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases. National Institute for Communicable Disease Control and Prevention. Chinese Center for Disease Control and Prevention (CDC). | |
| Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control. | |
| Centre de Recherche en Infectiologie Porcine (CRIP). Faculté de Médicine Vétérinaire. Université de Montréal (UM). | |
 | Servicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
 | College of Veterinary Medicine. University of Minnesota (UMM). |
| Institute of Infectious Diseases. Beijing Ditan Hospital. Capital Medical University. | |
| Yulin Center for Disease Prevention and Control. | |
| MOE Joint International Research Laboratory of Animal Health and Food Safety. College of Veterinary Medicine. Nanjing Agricultural University. | |
