Investigación publicada en Microbial Drug Resistance (Larchmont, N.Y.)

1 de octubre de 2013

A screening of antimicrobial resistance and its genetic determinants has been performed on 300 Salmonella enterica isolates collected during 2004-2008 from human infections in Spain. Salmonella Typhimurium and Salmonella Enteritidis were the major serotypes, which were found with similar frequencies covering 80% of the bacterial collection. Salmonella Typhimurium isolates frequently shared low susceptibility to antimicrobials of the penta-resistance phenotype (ACSSuT) and/or cephalosporin resistance. The ACSSuT profile was found closely linked to int1-associated gene cassettes, with major elements carrying DNA fragments of 1.0 Kb (aadA2 gene) plus 1.2 Kb (blaPSE-1 gene) or 2.0 Kb (aadA1 and blaOXA-1 genes). Among these, ACSSuT and cephalosporin resistances were associated in Salmonella Typhimurium isolates expressing the blaOXA gene. β-lactamase activities were also detected from isolates carrying blaTEM, blaCMY, or blaSHV, although only the two last genes expressed extended-spectrum β-lactamases. The clonal analysis of S. enterica strains suggests that both horizontal and vertical transfer mechanisms are involved in the wide dissemination of their antimicrobial resistance

Campos MJ., Palomo G., Hormeno L., Ugarte-Ruiz M., Porrero MC., Herrera-Leon S., Vadillo S., Piriz S. y Quesada A.

Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain

Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain

	Servicio de Bacteriología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).
	Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Escola Superior de Turismo e Tecnologia do Mar. Instituto Politécnico de Leiria (IPL).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Departamento de Bioquímica, Biología Molecular y Genética. Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad de Extremadura (UNEX).