Molecular and epidemiological population-based integrative analysis of human and animal Mycobacterium bovis infections in a low-prevalence setting
Veterinary Microbiology publica este artículo de investigación
15 de noviembre de 2016
Human Mycobacterium bovis infections are considered to be due to reactivations, when involve elderly people, or to recent transmissions, when exposure is occupational. We determined the cause of M. bovis infections by genotyping M. bovis isolates in a population-based study integrating human and animal databases. Among the 1,586 tuberculosis (TB) cases in Asturias, Northern Spain (1,080,000 inhabitants), 1567 corresponded to M. tuberculosis and 19 to M. bovis. The number of human isolates sharing genotype with cattle isolates was higher than expected (47%) for a setting with low prevalence of bovine TB and efficient control programs in cattle. The risk of exposure to infected animals was probable/possible in most of these matched cases (77.7%). Recent transmission was the likely explanation of most M. bovis infections in elderly people. A potential human-to-human transmission was found. Our study illustrates a model of collaboration between human and animal health professionals to provide a precise snapshot of the transmission of M. bovis in the human-animal interface
Palacios JJ., Navarro Y., Romero B., Penedo A., Menendez-Gonzalez A., Perez Hernandez MD., Fernandez-Verdugo A., Copano F., Torreblanca A., Bouza E., Dominguez L., de Juan L. y Garcia de Viedma D.
 | Unidad de Referencia Regional de Micobacterias. Hospital Universitario Central de Asturias. Servicio de Salud del Principado de Asturias (SESPA). Gobierno del Principado de Asturias. |
 | Servicio de Microbiología y Enfermedades Infecciosas. Hospital General Universitario Gregorio Marañón. Salud Madrid. Comunidad de Madrid. |
| Instituto de Investigación Sanitaria Gregorio Marañón (IISGM). Hospital General Universitario Gregorio Marañón. Salud Madrid. Comunidad de Madrid. |
 | Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Instituto de Salud Carlos III (ISCIII). |
 | CEI Campus Moncloa. |
 | Servicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Servicio de Vigilancia y Alertas Epidemiológicas. Dirección General de Salud Pública. Consejería de Sanidad. Gobierno del Principado de Asturias. |
| Laboratorio de Sanidad Animal. Gobierno del Principado de Asturias. |
| Servicio de Microbiología. Hospital de Cabueñes. Servicio de Salud del Principado de Asturias (SESPA). Gobierno del Principado de Asturias. |
| Departamento de Medicina. Facultad de Medicina. Universidad Complutense (UCM). |
| Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
