SatR is a repressor of fluoroquinolone efflux pump SatAB
Artículo de investigación publicado en Antimicrobial Agents and Chemotherapy
1 de julio de 2013
Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here we describe and characterize satR, an ORF encoding a MarR-superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB and its interruption entails the overexpression of the pump, leading to a clinically-relevant increase in resistance to fluoroquinolones
Escudero JA., San Millan A., Montero N., Gutierrez B., Ovejero CM., Carrilero L. y Gonzalez-Zorn B..
 | Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
