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Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge

Investigación publicada en Comparative Immunology, Microbiology and Infectious Diseases

1 de octubre de 2018

Caprine TB causes chronic disease with severe economic and health consequences. We assessed the effect of intramuscularly administered heat-inactivated Mycobacterium bovis (M. bovis) on 20 kid goats (10 vaccinated, 10 controls), naturally exposed to M. caprae through close contact with infected goats. At necropsy, visible TB-compatible lesions were recorded in all animals with the exception of 1 control and 2 vaccinated goats. The median of the total lesion score was 9 (IQR 3-13.5) and 5 (IQR 3-6.75) in control and vaccinated goats, respectively (median lesion reduction 44.4%, p =  0.224). The lung lesions of the vaccinated goats were restricted to the caudal lobes, while 6 controls had additional lung lobes affected (p =  0.01). The median lung lesion score reduction in vaccinated goats was 100%; however, this reduction was not significant (p =  0.124), possibly due to the low sample size. Regarding the abdomen, only one vaccinated goat presented visible lesions compared to three goats in the control group. The results provide further evidence of the potential of heat-inactivated M. bovis for controlling TB in different host species, including ruminants




Roy A., Risalde MA., Bezos J., Casal C., Romero B., Sevilla I., Diez-Guerrier A., Rodriguez-Bertos A., Dominguez M., Garrido J., Gortazar C. y Dominguez L..




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Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge

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Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge

Participantes:

CZ Veterinaria, S.A.CZ Veterinaria, S.A. (CZV).

Universidad ComplutenseServicio de Micobacterias (MYC). Servicio de Ensayos Clínicos (SEC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad de CórdobaDepartamento de Anatomía y Anatomía Patológica Comparadas. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Laboratorios SYVA, S.A.Laboratorios SYVA, S.A..

Gobierno VascoNeiker-Tecnalia, Instituto Vasco de Investigación y Desarrollo Agrario. Gobierno Vasco.

MAEVA SERVET, S.L.MAEVA SERVET, S.L..

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Instituto de Salud Carlos IIIServicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).







Comparative Immunology, Microbiology and Infectious Diseases
FACTOR YEAR Q
1.871 2018

NLMID: 7808924

PMID: 30396427

ISSN: 0147-9571



TÍTULO: Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge


REVISTA: Comp. Immunol. Microbiol. Infect. Dis.


NUMERACIÓN: 60:28-34


AÑO: 2018


EDITORIAL: Elsevier Science


AUTORES: Roy A., Risalde MA., Bezos J., Casal C., Romero B., Sevilla I., Diez-Guerrier A., Rodriguez-Bertos A., Dominguez M., Garrido J., Gortazar C. and Dominguez L..


PARTICIPANTES VISAVET


3rd
Javier Bezos Garrido
5th
Beatriz Romero Martínez
7th
Alberto Antoine Díez Guerrier
8th
Antonio Manuel Rodríguez Bertos
Last
Lucas Domínguez Rodríguez

DOI: https://doi.org/10.1016/j.cimid.2018.09.006


CITA ESTA PUBLICACIÓN:

Roy A., Risalde MA., Bezos J., Casal C., Romero B., Sevilla I., Diez-Guerrier A., Rodriguez-Bertos A., Dominguez M., Garrido J., Gortazar C. y Dominguez L. Response of goats to intramuscular vaccination with heat-killed Mycobacterium bovis and natural challenge. Comparative Immunology, Microbiology and Infectious Diseases. 60:28-34. 2018. (A). ISSN: 0147-9571. DOI: 10.1016/j.cimid.2018.09.006


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