Investigation article published in Antibiotics

March 10^th, 2023

Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among
the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins
(ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal,
human, and environmental sources and its resistant phenotype, derived from the carriage of plasmidborne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial
therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible
sources involved in its transmission, and its study would require databases ideally comprising
information from animal (livestock, companion, wildlife), human, and environmental sources. Here,
we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here

Perestrelo S., Amaro A., Brouwer MSM., Clemente L., Ribeiro-Duarte AS., Kaesbohrer A., Karpiskova R., Lopez-Chavarrias V., Morris D., Prendergast D., Pista A., Silveira L., Skarzynska M., Slowey R., Veldman KT., Zajac M., Burgess C. and Alvarez J..

Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL-AmpC Producing E. coli as An Example-Challenges and Perspectives

Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL-AmpC Producing E. coli as An Example-Challenges and Perspectives

	Department Biological Safety. German Federal Institute for Risk Assessment.
	National Reference Laboratory for Animal Health.
	Host-Pathogen interactions and Diagnostic Development. Wageningen Bioveterinary Research.
	National Food Institute (DTU Food). Technical University of Denmark (DTU).
	University of Veterinary Medicine (UNIVET).
	Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Antimicrobial Resistance and Microbial Ecology Group. School of Medicine. National University of Ireland Galway (NUIG).
	Central Veterinary Research Laboratory, Backweston Laboratory Complex. Department of Agriculture, Food and the Marine (DAFM).
	National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (Nrl-Amr/Hai). Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA).
	National Veterinary Research Institute (NVRI).
	Teagasc Food Research Centre.
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).