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Last research news
January 7th, 2020
Vía publiDB
Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration
Cell metabolism publish this investigation article
Life on Earth emerged in a hydrogen sulfide (H2S)-rich environment eons ago and with it protein persulfidation mediated by H2S evolved as a signaling mechanism. Protein persulfidation (S-sulfhydration) is a post-translational modification of reactive cysteine residues, which modulate protein structure and/or function. Persulfides are difficult to label and study due to their reactivity and similarity with cysteine. Here, we report a facile strategy for chemoselective persulfide bioconjugation using dimedone-based probes, to achieve highly selective, rapid, and robust persulfide labeling in bio…
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January 1st, 2020
Vía publiDB
Econometric ARIMA methodology to elucidate the evolution of trends in nosocomial antimicrobial resistance rates in the European Union
International Journal of Antimicrobial Agents publish this investigation article
BACKGROUND:
Infectious pathogens harboring cephalosporin or fluoroquinolones resistance constitute a serious hazard to human health.
OBJECTIVES:
The aim of this study is to set up a methodology based on econometric analysis and largest European Union (EU) resistance database (EARS-Net) to model EU nosocomial antimicrobial resistance (AMR) and to detect tendency changes, steps or peaks. The contribution of legislation based on third generation cephalosporin (3GC) and fluoroquinolones (FQ) class referrals on EU resistance rate patterns is evaluated.
METHODS:
We studied 3GC and FQ resistance…
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January 1st, 2020
Vía publiDB
Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain
Investigation article published in Transboundary and Emerging Diseases
Despite of controls and preventive measures implemented along the food chain, infection with non-typhoidal Salmonella (NTS) remains one of the major causes of foodborne disease worldwide. Poultry is considered one of the major sources of NTS. This has led to the implementation of monitoring and control programs in many countries (including Spain) to ensure that in poultry flocks infection is kept to a minimum and to allow the identification and monitoring of circulating NTS strains and their antimicrobial resistance (AMR) phenotypes. Here, we investigated the information from the monitoring pr…
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December 21st, 2019
Vía publiDB
Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions
Investigation article published in The Veterinary Record
BACKGROUND:
There is evidence for a link between vitamin D deficiency and active tuberculosis (TB). In human beings, several trials have evaluated the role of vitamin D supplementation in TB treatment with conflicting results. However, the role of vitamin D supplementation in animal TB control has received less attention. The authors evaluated the benefit of vitamin D supplementation for preventing mycobacterial infection or reducing TB lesions (TBL) in a controlled trial with goats naturally exposed to Mycobacterium caprae.
METHODS:
Two groups of goats, a vitamin D-supplemented group…
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December 16th, 2019
Vía publiDB
Antimicrobial susceptibility of Pasteurella multocida isolated from sheep and pigs in Spain - Short communication
Investigation published in Acta veterinaria Hungarica
Pasteurella multocida is responsible for economically important diseases in sheep and pigs. Antimicrobial susceptibility studies are essential for initiating rational and effective empirical therapy of P. multocida infections. In this study we investigated the antimicrobial susceptibility to 18 antimicrobial agents of 156 clinical isolates of P. multocida from sheep (n = 87) and pigs (n = 69) using the microdilution method. Both sheep and pig isolates exhibited low levels of resistance (≤ 15%) to ceftiofur, gentamicin, neomycin, spectinomycin, chlortetracycline, tulathromycin, florfenico…
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December 10th, 2019
Vía publiDB
Tuberculosis Epidemiology and Badger (Meles meles) Spatial Ecology in a Hot-Spot Area in Atlantic Spain
Pathogens publish this investigation article
We provide a temporal overview (from 2012 to 2018) of the outcomes of tuberculosis (TB) in the cattle and badger populations in a hot-spot in Asturias (Atlantic Spain). We also study the badger’s spatial ecology from an epidemiological perspective in order to describe hazardous behavior in relation to TB transmission between cattle and badgers. Culture and single intradermal tuberculin test (SITT) were available for cattle as part of the National Program for the Eradication of TB. A field survey was also carried out in order to determine the paddocks and buildings used by each farm, and the in…
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December 7th, 2019
Vía publiDB
Association between results of diagnostic tests for bovine tuberculosis and Johne`s disease in cattle
Investigation published in The Veterinary Record
BACKGROUND:
Bovine tuberculosis (bTB) diagnosis is impaired by numerous factors including cross-reactivity with Mycobacterium avium subspecies paratuberculosis, which causes Johne`s disease (JD). In addition, the effect of repeated bTB-intradermal testing on the performance of JD diagnostic tests is not fully understood. This study aimed to evaluate the impact of repeated bTB-intradermal tests under field conditions in Spain on the JD serological status of cattle.
METHODS:
bTB-positive herds (n=264) from Castilla-y-Leon region were selected and matched with officially tuberculosis-free co…
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December 2nd, 2019
Vía publiDB
Use of a voluntary testing program to study the spatial epidemiology of Johne’s disease affecting dairy herds in Minnesota: a cross sectional study
Investigation article published in BMC Veterinary Research
One of the key steps in the management of chronic diseases in animals including Johne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is the ability to track disease incidence over space and time. JD surveillance in the U.S. dairy cattle is challenging due to lack of regulatory requirements, imperfect diagnostic tests, and associated expenses, including time and labor. An alternative approach is to use voluntary testing programs. Here, data from a voluntary JD testing program, conducted by the Minnesota Dairy Herd Improvement Association, were used to: a) explore w…
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December 1st, 2019
Vía publiDB
Assessment of the sensitivity of the bovine tuberculosis eradication program in a high prevalence region of Spain using scenario tree modeling
Investigation published in Preventive Veterinary Medicine
In spite of the efforts invested to eradicate bovine tuberculosis (bTB) in cattle, the disease is still present in several developed countries, including Spain. Among the factors related with disease persistence in high prevalence areas, the lack of sensitivity of the screening test for detection of infected herds [single intradermal tuberculin (SIT) test] can play a major role. Here, a scenario tree model mimicking the diagnostic test scheme in place in the region of Castilla y Leon (Spain) was developed to estimate the probability of detecting bTB in an infected-non detected officially tuber…
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December 1st, 2019
Vía publiDB
Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease
Investigation published in Environmental Microbiology
The use of antimicrobials in human and veterinary medicine has coincided with a rise in antimicrobial resistance (AMR) in the food‐borne pathogens Campylobacter jejuni and Campylobacter coli. Faecal contamination from the main reservoir hosts (livestock, especially poultry) is the principal route of human infection but little is known about the spread of AMR among source and sink populations. In particular, questions remain about how Campylobacter resistomes interact between species and hosts, and the potential role of sewage as a conduit for the spread of AMR. Here we investigate the ge…
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