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Last research news
November 12nd, 2025
Vía publiDB
Evaluation of serological assays for intra vitam diagnosis of bovine tuberculosis in water buffalo (Bubalus bubalis)
Investigation published in Frontiers in Microbiology
Introduction: Bovine tuberculosis (TB) in water buffalo (Bubalus bubalis) is primarily diagnosed using intra vitam tests, as the intradermal tuberculin test (IDT) and the interferon-gamma release assay (IGRA), both of which detect cell-mediated immunity (CMI). However, a subset of infected animals fails to mount a detectable CMI response, posing a significant risk of undetected transmission. Serological tests assessing the humoral immune response could provide a valuable complementary tool for identifying infected animals that escape detection through traditional CMI-based assays.
Methods: Th…
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November 12nd, 2025
Vía publiDB
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital
Investigation article published in Journal of Clinical Microbiology
Aminoglycoside resistance mediated by 16S rRNA methyltransferases poses a growing threat in both human and veterinary medicine. Here, we conducted a retrospective genomic study of Enterobacterales isolates (n = 789) collected from clinical samples at a veterinary teaching hospital in Spain between 2011 and 2020. We identified four high-level aminoglycoside-resistant ST171 Enterobacter hormaechei subsp. xiangfangensis isolates carrying the armA gene, all from horses. Using Illumina and Nanopore sequencing, we determined that armA was located on a 70 kb IncR plasmid, also carrying other resistan…
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November 11st, 2025
Vía publiDB
A time-space Bayesian regression model of rabies cases in the animal population of Kazakhstan (2013-2023)
Frontiers in veterinary science publish this investigation article
Despite its endemic status and socioeconomic impacts, the spatial-temporal variation in rabies risk and its underlying determinants in Kazakhstan animal populations remain poorly understood. This study aimed to characterise the time-space dynamics of rabies in animal populations across Kazakhstan regions from 2013 to 2023 and identify the key drivers of transmission. Using a Bayesian hierarchical regression model with spatial and temporal random effects, we analysed national surveillance data on rabies cases in livestock, companion animals, and wildlife, alongside sociodemographic and animal p…
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November 4th, 2025
Vía publiDB
Protective effect of heat-inactivated Mycobacterium bovis applied intramuscularly is associated with enhanced lung immune response in caprine tuberculosis
Investigation published in Veterinary Research
Caprine tuberculosis (TB) causes a zoonotic disease with significant economic and health implications. However, excluding some regions, goat herds are not subjected to official TB eradication programs. Implementing vaccination protocols for this species could provide a complementary and effective control strategy against TB. We assessed the protective efficacy and immune response associated with a heat-inactivated Mycobacterium bovis (M. bovis)-based immunostimulant (HIMB) applied intramuscularly against caprine pulmonary TB on 20 kid goats (10 immunized, 10 controls) naturally exposed to M. c…
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November 1st, 2025
Vía publiDB
Attributable sources of the five most prevalent non-typhoidal Salmonella serovars across ten European countries
Investigation published in The Journal of infection
Non-typhoidal Salmonella is the second most frequently reported zoonotic pathogen in the European Union and European Economic Area. Most human infections are caused by serovars Enteritidis and Typhimurium. Genomic characterisation of Salmonella isolates from humans and animals has become a routine public health surveillance tool in many countries. In this study, the relative contributions of several potential sources of human infection of the five frequently reported Salmonella serovars was estimated using machine-learning methods based on a large, cross-sectional collection of genomes from hu…
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November 1st, 2025
Vía publiDB
Diving Into the Depths: Unveiling the Main Etiologies of Piscine Lactococcosis With a Novel Multiplex qPCR Assay
Investigation published in Journal of Fish Diseases
Piscine lactococcosis poses a significant threat to a wide range of cultured and wild fish populations worldwide, typically presenting as acute haemorrhagic septicemia with high morbidity and mortality. Although Lactococcus garvieae was historically considered the sole causative agent of piscine lactococcosis, recent studies have identified L. petauri and L. formosensis as additional, highly pathogenic species. In this study, we developed a novel TaqMan-based multiplex qPCR assay for the simultaneous detection and differentiation of L. garvieae, L. petauri and L. formosensis, following a pange…
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October 28th, 2025
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Healthcare-related transmission of mobile genetic elements co-carrying blaNDM and 16S rRNA methyltransferase genes in multiple Enterobacterales
Microbial Genomics publish this investigation article
Aminoglycosides are used in the treatment of serious infections with Gram-negative bacteria, especially those resistant to beta-lactams and carbapenems. 16S rRNA methyltransferases (16S-RMTase) are capable of conferring resistance to nearly all aminoglycosides. They are sometimes detected in combination with bla NDM. This study describes the mobile genetic elements associated with bla NDM and 16S-RMTase (co-)carriage in Enterobacterales from Ireland in the period 2019-2023. All isolates (n=58) carrying both bla NDM and a 16S-RMTase gene between 2019 and 2023 were obtained from the CPE National…
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October 24th, 2025
Vía publiDB
WiBISS: a tool to estimate avoided lost revenue of African swine fever wild boar vaccination at municipality level
Frontiers in veterinary science publish this investigation article
This study introduces the WiBISS model, a simulation tool designed to assess the economic and epidemiological impact of a hypothetical African Swine Fever (ASF) vaccination in wild boar in Northern Italy. Using real ASF outbreak data from January 2022 to June 2024, the model evaluates how prompt vaccination could reduce disease spread and economic losses. WiBISS integrates three modules: vaccination simulation, restriction zone estimation, and economic impact analysis. The first two use custom-built cellular automata (CA) in Python and ArcGIS Pro, modeling each ASF case as a cell that can be i…
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October 22nd, 2025
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Primary leptomeningeal histiocytic lymphoproliferative disorder associated with SARS-CoV-2 brain infection in k18-hACE2 mouse: a case report
Laboratory Animal Research publish this investigation article
Background: Histiocytic proliferative disorders in the central nervous system are rare, and their potential association with viral infections remains largely unexplored. This case is relevant because it suggests a potential interaction between SARS-CoV-2 neuroinvasion and tumor development, providing insights into how viral infections might influence oncogenesis.
Case presentation: A 4.5-month-old male k18-hACE-2 mouse, part of an experimental study of SARS-CoV-2, displayed a small mass in leptomeningeal area composed by neoplastic round cells. This process is associated with typical acute in…
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October 22nd, 2025
Vía publiDB
Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model
Investigation published in Applied and Environmental Microbiology
The guts of animals and humans harbor diverse microbial communities that are regularly exposed to bacteria originating from food, water, and their surroundings. Species such as Escherichia coli are adept at colonizing multiple hosts, along with surviving in the environment. By encoding pathogenic traits and transmissible forms of antimicrobial resistance (AMR), E. coli can also pose a zoonotic risk. Our understanding of the factors that govern host residency is limited. Here, we used a chicken cecal fermentation model to study survival and the AMR transfer potential of 17 host-associated exten…
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