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Last research news
December 9th, 2025
Vía publiDB
Viral Distribution of Wild Boar Exposed to Low (Vaccine Candidate) and High Virulence African Swine Fever Virus Isolates: Immunohistochemical Characterization
Investigation published in Transboundary and Emerging Diseases
Although several biosecurity and control measures are currently in place to mitigate the African swine fever (ASF) epidemic, vaccination is being explored as a potential long-term strategy. However, standardized guidelines for evaluating the safety and efficacy of ASF vaccines are not yet fully established. Understanding infection dynamics in wild boar is crucial, as they play a key role in the spread and persistence of the virus. This work aims to provide comprehensive information on viral distribution through immunohistochemical analysis (p72) with histopathologic assessment in wild boar. Th…
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December 1st, 2025
Vía publiDB
Retrospective analysis of the clinical approach practiced in dog bite cases caused by Vipera latastei, Vipera seoanei and Vipera aspis
Investigation article published in The Veterinary Journal
Snakebites pose a significant public health risk to both humans and animals in many countries. In Spain, the presence of three viper species, Vipera latastei, Vipera seoanei, and Vipera aspis, complicates clinical management in veterinary settings. There is currently no standardized veterinary protocol for treating viper bites in many countries. This retrospective study analyzed the clinical approaches employed by Spanish veterinary centers in treating canine viper bites within the distribution range of these species. Data from 62 clinical cases across 58 veterinary centers were reviewed, incl…
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November 21st, 2025
Vía publiDB
Risk Mapping of African Swine Fever in Domestic Pigs and Wild Boars to Enhance Management and Surveillance in Asia
Transboundary and Emerging Diseases publish this investigation article
African swine fever (ASF) is a highly lethal disease affecting domestic pigs and wild boars, caused by the ASF virus (ASFV), which has rapidly spread across Asia in recent years. In this region, most reported ASF cases involve domestic pigs, while cases in wild boars remain notably lower except in a few countries. However, factors such as the high population of wild boars, limited wildlife surveillance, and inadequate farm biosecurity suggest that the prevalence and transmission of ASFV between these hosts may be underestimated. Therefore, we used a simplified multicriteria approach (SMCA) to …
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November 19th, 2025
Vía publiDB
Complement system activation in wild boar (Sus scrofa) following parenteral administration of heat-inactivated Mycobacterium bovis
Investigation article published in Frontiers in veterinary science
Introduction: Development of vaccines to preserve and improve human and animal health requires effective protective antigens, delivery platforms, and adjuvants. The immunostimulant based on heat-inactivated Mycobacterium bovis (IV) was developed to boost protective immune response in different animal species against pathogen infection and tick infestations.
Methods: In this study, a serum proteomics approach was used with functional annotations and enrichment network analysis for the characterization of immune pathways and biomarkers associated with parenteral administration of one, two, or t…
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November 14th, 2025
Vía publiDB
Antibiotic Resistance to Critically Important Antimicrobials and Virulence Genes in Enterococcus faecalis Strains Isolated from Eurasian Griffon Vultures (Gyps fulvus) and Their Association with Mobile Genetic Elements
Investigation article published in Veterinary sciences
The phenotypic resistance of 56 Enterococcus faecalis isolates from Eurasian griffon vultures was subjected to surveillance testing with the microdilution method using a standardized panel of antimicrobials. Isolates were also characterized by MLST. Additionally, the genome of 19 isolates with phenotypic resistance to linezolid, ciprofloxacin, chloramphenicol and/or high-level resistance to gentamicin were sequenced to determine their antimicrobial resistance (ARGs) and virulence-associated genes and to identify mobile genetic elements (MGEs). Most isolates (82.1%) exhibited non-wild-type phen…
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November 12nd, 2025
Vía publiDB
Evaluation of serological assays for intra vitam diagnosis of bovine tuberculosis in water buffalo (Bubalus bubalis)
Investigation published in Frontiers in Microbiology
Introduction: Bovine tuberculosis (TB) in water buffalo (Bubalus bubalis) is primarily diagnosed using intra vitam tests, as the intradermal tuberculin test (IDT) and the interferon-gamma release assay (IGRA), both of which detect cell-mediated immunity (CMI). However, a subset of infected animals fails to mount a detectable CMI response, posing a significant risk of undetected transmission. Serological tests assessing the humoral immune response could provide a valuable complementary tool for identifying infected animals that escape detection through traditional CMI-based assays.
Methods: Th…
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November 12nd, 2025
Vía publiDB
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital
Investigation article published in Journal of Clinical Microbiology
Aminoglycoside resistance mediated by 16S rRNA methyltransferases poses a growing threat in both human and veterinary medicine. Here, we conducted a retrospective genomic study of Enterobacterales isolates (n = 789) collected from clinical samples at a veterinary teaching hospital in Spain between 2011 and 2020. We identified four high-level aminoglycoside-resistant ST171 Enterobacter hormaechei subsp. xiangfangensis isolates carrying the armA gene, all from horses. Using Illumina and Nanopore sequencing, we determined that armA was located on a 70 kb IncR plasmid, also carrying other resistan…
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November 11st, 2025
Vía publiDB
A time-space Bayesian regression model of rabies cases in the animal population of Kazakhstan (2013-2023)
Frontiers in veterinary science publish this investigation article
Despite its endemic status and socioeconomic impacts, the spatial-temporal variation in rabies risk and its underlying determinants in Kazakhstan animal populations remain poorly understood. This study aimed to characterise the time-space dynamics of rabies in animal populations across Kazakhstan regions from 2013 to 2023 and identify the key drivers of transmission. Using a Bayesian hierarchical regression model with spatial and temporal random effects, we analysed national surveillance data on rabies cases in livestock, companion animals, and wildlife, alongside sociodemographic and animal p…
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November 4th, 2025
Vía publiDB
Protective effect of heat-inactivated Mycobacterium bovis applied intramuscularly is associated with enhanced lung immune response in caprine tuberculosis
Investigation published in Veterinary Research
Caprine tuberculosis (TB) causes a zoonotic disease with significant economic and health implications. However, excluding some regions, goat herds are not subjected to official TB eradication programs. Implementing vaccination protocols for this species could provide a complementary and effective control strategy against TB. We assessed the protective efficacy and immune response associated with a heat-inactivated Mycobacterium bovis (M. bovis)-based immunostimulant (HIMB) applied intramuscularly against caprine pulmonary TB on 20 kid goats (10 immunized, 10 controls) naturally exposed to M. c…
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November 1st, 2025
Vía publiDB
Exploring trained immunity to complement vaccination against Streptococcus suis in swine
Investigation article published in Developmental and Comparative Immunology
Streptococcus suis is a major pathogen in swine, causing septicemia, meningitis, and arthritis. Effective control is complicated by the presence of multiple serotypes, genetic heterogeneity, and interference of maternal antibodies with vaccine efficacy. Moreover, the emergence of antibiotic-resistant strains poses additional challenges. Trained immunity, a process of innate immune memory induced by certain stimuli, has been proposed as a novel approach to enhance host defense mechanisms. This study aimed to evaluate whether a mycobacterial-derived immunomodulator (dpB) administered with a spec…
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