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Last research news
January 15th, 2021
Vía publiDB
Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System
Sensors publish this investigation article
More effective methods to detect bovine tuberculosis, caused by Mycobacterium bovis, in wildlife, is of paramount importance for preventing disease spread to other wild animals, livestock, and human beings. In this study, we analyzed the volatile organic compounds emitted by fecal samples collected from free-ranging wild boar captured in Doñana National Park, Spain, with an electronic nose system based on organically-functionalized gold nanoparticles. The animals were separated by the age group for performing the analysis. Adult (>24 months) and sub-adult (12–24 months) animals were anestheti…
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December 17th, 2020
Vía publiDB

Use of Epidemiological Analytic Tools and Molecular Characterization Techniques to Inform Bovine Tuberculosis Eradication Programs
PhD Thesis defense by Pilar Pozo Piñol at the VISAVET Centre of the Complutense University of Madrid
Bovine tuberculosis (bTB) is an infectious disease with a complex epidemiology at the human-animal-environment interface which, despite the application of extensive control measures, is still prevalent in livestock and wildlife in several regions of Spain. The disease, caused by Mycobacterium bovis (and to a lesser extent M. caprae), remains a concern due to its negative impact on animal health and welfare, together with the important consequences for production and animal trade that its presence imposes. Eradication programs of bTB in cattle in Spain are based on a combination of regular test…
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December 16th, 2020
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Distinct African Swine Fever Virus Shedding in Wild Boar Infected with Virulent and Attenuated Isolates
Vaccine publish this investigation article
Abstract: Since the reappearance of African swine fever virus (ASFV), the disease has spread in an unprecedented animal pandemic in Eurasia. ASF currently constitutes the greatest global problem for the swine industry. The wild boar (Sus scrofa) in which the pathogen has established wild self-sustaining cycles, is a key reservoir for ASFV, signifying that there is an urgent need to develop an effective vaccine against this virus. Current scientific debate addresses whether live attenuated vaccines (LAVs), which have shown promising results in cross-protection of susceptible hosts, may be feasi…
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December 15th, 2020
Vía publiDB
Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions
Investigation published in eLife
Abstract Molecular examples of evolutionary innovation are scarce and generally involve point mutations. Innovation can occur through larger rearrangements, but here experimental data is extremely limited. Integron integrases innovated from double-strand- toward single-strand-DNA recombination through the acquisition of the I2 a-helix. To investigate how this transition was possible, we have evolved integrase IntI1 to what should correspond to an early innovation state by selecting for its ancestral activity. Using synonymous alleles to enlarge sequence space exploration, we have retrieved 13…
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December 11st, 2020
Vía publiDB

Evaluation of new vaccines against tuberculosis in goats and advances in their immunological diagnosis
PhD Thesis defense by Álvaro Roy Cordero at the VISAVET Centre of the Complutense University of Madrid
Tuberculosis in goats is a zoonotic mycobacteriosis, mainly caused by M. caprae and M. bovis, which leads to important economic losses for the goat producers and may represent a reservoir of tuberculosis for other domestic and wild animal species, as well as humans. At the European level, the active diagnosis of tuberculosis in goats is limited to goat herds coexisting or having epidemiological links with infected cattle or when raw milk and products made from raw milk are intended for human consumption (European Regulation EC 853/2004). However, specific eradication programs have been impleme…
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- Análisis y eficacia de las técnicas de diagnóstico ante la tuberculosis caprina - interempresas.net
- Evalúan los últimos test y vacunas de tuberculosis caprina - animalshealth.es
December 10th, 2020
Vía publiDB

Global emergence and evolutionary dynamics of bluetongue virus
Investigation published in Scientific reports
Bluetongue virus (BTV) epidemics are responsible for worldwide economic losses of up to US$ 3 billion. Understanding the global evolutionary epidemiology of BTV is critical in designing intervention programs. Here we employed phylodynamic models to quantify the evolutionary characteristics, spatiotemporal origins, and multi-host transmission dynamics of BTV across the globe. We inferred that goats are the ancestral hosts for BTV but are less likely to be important for cross-species transmission, sheep and cattle continue to be important for the transmission and maintenance of infection between…
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December 4th, 2020
Vía publiDB
Histopathological and microbiological study of porcine lymphadenitis: contributions to diagnosis and control of the disease
Investigation article published in Porcine Health Management
Tuberculosis like lesions (TBL) in free-range pigs are characterised by presenting a marked heterogeneity in pathology and microbiology features, with a notorious role of Mycobacterium tuberculosis complex (MTC), Trueperella pyogenes and different Streptococcus species. However, the capacity of these microorganism to spread to different organic cavities leading to a generalised disease is unknown. Therefore, this study evaluated the organic distribution of these agents in free-range pig carcasses whole condemned due to generalised TBL.A total of 37 totally condemned animals were analysed, and …
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December 3rd, 2020
Vía publiDB

Molecular detection of extended spectrum B-lactamase genes in Escherichia coli clinical isolates from diarrhoeic children in Kano, Nigeria
PLoS ONE publish this investigation article
The increase in antimicrobial resistance in developed and developing countries is a global public health challenge. In this context β-lactamase production is a major contributing factor to resistance globally. The aim of this study was to determine the prevalence of phenotypic and genotypic extended spectrum β-lactamases (ESBLs) in 296 E. coli isolates recovered from diarrhoeic children younger than five years in Kano whose susceptibility profile against 7 antimicrobials had been determined. The E. coli isolates were subjected to double disc synergy test for phenotypic ESBLs detectio…
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November 29th, 2020
Vía publiDB
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Computer Vision Applied to Detect Lethargy through Animal Motion Monitoring: A Trial on African Swine Fever in Wild Boar
Investigation article published in Animals
Early detection of infectious diseases is the most cost-effective strategy in disease surveillance for reducing the risk of outbreaks. Latest deep learning and computer vision improvements are powerful tools that potentially open up a new field of research in epidemiology and disease control. These techniques were used here to develop an algorithm aimed to track and compute animal motion in real time. This algorithm was used in experimental trials in order to assess African swine fever (ASF) infection course in Eurasian wild boar. Overall, the outcomes showed negative correlation between motio…
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November 26th, 2020
Vía publiDB
A one health framework to estimate the cost of antimicrobial resistance
Antimicrobial Resistance and Infection Control publish this investigation article
Objectives/purpose: The costs attributable to antimicrobial resistance (AMR) remain theoretical and largely unspecified. Current figures fail to capture the full health and economic burden caused by AMR across human, animal, and environmental health; historically many studies have considered only direct costs associated with human infection from a hospital perspective, primarily from high-income countries. The Global Antimicrobial Resistance Platform for ONE-Burden Estimates (GAP-ON€) network has developed a framework to help guide AMR costing exercises in any part of the world as a first step…
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