Research Lines
Scientific Research lines of VISAVET Centre
Research Projects
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Scientific Publications
SCI Scientific Publications of VISAVET Centre
Thesis
PhD Thesis and scientific
dissertations of VISAVET Centre
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Last research news
January 3rd, 2019
Vía publiDB
Revisiting area risk classification of visceral leishmaniasis in Brazil
Investigation article published in BMC infectious diseases
Background: Visceral leishmaniasis (VL) is a neglected tropical disease of public health relevance in Brazil. To prioritize disease control measures, the Secretaria de Vigilância em Saúde of Brazil’s Ministry of Health (SVS/MH) uses retrospective human case counts from VL surveillance data to inform a municipality-based risk classification. In this study, we compared the underlying VL risk, using a spatiotemporal explicit Bayesian hierarchical model (BHM), with the risk classification currently in use by the Brazil’s Ministry of Health. We aim to assess how well the current risk classes captur…
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January 1st, 2019
Vía publiDB
Validation of a new serological assay for the identification of Mycobacterium tuberculosis complex-specific antibodies in pigs and wild boar
Investigation published in Preventive Veterinary Medicine
Background and objectives
Animal tuberculosis (TB) is a multi-host disease involving a wide variety of domestic and wild mammals and causing a significant economic burden and sanitary problems. Wild boar and domestic pigs (Sus scrofa) are indicators of the circulation of the Mycobacterium tuberculosis complex (MTC) and can play a role in its maintenance. The proper diagnosis of MTC contact in these species is, therefore, a key factor as regards controlling TB. The objective of the current study is to evaluate the diagnostic performance of the protein complex P22 as a candidate for use in an i…
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December 19th, 2018
Vía publiDB
Application of quantitative analytic methods for the epidemiological study of zoonotic diseases
PhD Thesis defense by Mª Luisa de la Cruz Conty at the Faculty of Veterinary Medicine of de Complutense University of Madrid
The present doctoral thesis explored the usefulness of the application of quantitative analytic methods for the study of the epidemiology of diseases of relevance in animal and public health.
Most epidemiological studies are based on the classification of individuals from a given population as infected or uninfected based on the results obtained in a diagnostic test.
However, often the accuracy of the test is not formally evaluated, or estimates obtained in a different (and non-applicable) context are merely extrapolated, what can lead to important biases. In this thesis, Bayesian models…
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December 14th, 2018
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Immunoproteomic characterization of protein derivatives from Mycobacterium bovis, Mycobacterium avium (subspecies avium and paratuberculosis) and Corynebacterium pseudotuberculosis. Application in diagnosis
Jose Antonio Infantes Lorenzo defended the PhD Thesis at the Faculty of Veterinary Medicine of de Complutense University of Madrid
Animal tuberculosis is a zoonotic infection caused by members of the Mycobacterium tuberculosis complex (MTBC), especially M. bovis and M. caprae. It represents an important health problem, in humans, domestic animals and wildlife. For this reason, in the European Union, cattle are subject to an eradication programme, based on " test-and slaughter" strategies, which implies the removal of animals that react positively to diagnostic tests. The official diagnostic tests are based on the cell immune response against the bovine tuberculin or PPDb. This is a purified protein derivative (PPD) prepar…
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December 13rd, 2018
Vía publiDB
Quantitative and qualitative analysis of antimicrobial usage patterns in 180 selected farrow-to-finish pig farms from nine European countries based on single batch and purchase data
Investigation published in The Journal of Antimicrobial Chemotherapy
EFFORT consortium
Haitske Graveland2 , Alieda van Essen4, Bruno Gonzalez-Zorn8, Gabriel Moyano8, Pascal Sanders9, Claire Chauvin9, Julie David9, Antonio Battisti10, Andrea Caprioli10, Jeroen Dewulf11, Thomas Blaha12, Katharina Wadepohl12, Maximiliane Brandt12, Dariusz Wasyl13, Magdalena Skarzyńska13, Magdalena Zajac13, Hristo Daskalov14, Helmut W. Saatkamp4 and Katharina D. C. Stärk15
OBJECTIVES:
Farm-level quantification of antimicrobial usage (AMU) in pig farms.
METHODS:
In a cross-sectional study, AMU data on group treatments administered to a single batch of fattening pigs from b…
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December 4th, 2018
Vía publiDB
Antimicrobial Prescriptions for Dogs in the Capital of Spain
Frontiers in veterinary science publish this investigation article
Objective: To characterize antimicrobial prescription patterns for dogs in veterinary practices in Spain using the city of Madrid as a model.
Design: Retrospective survey.
Settings: Dogs attending veterinary practices in the city of Madrid in 2017 were enrolled.
Subjects: Three hundred dogs from 30 veterinary practices randomly selected from a set of 388 practices grouped by zip code. The inclusion criterion for dogs was treatment with antibiotics within a few days of the data collection day.
Results: For the 300 dogs enrolled, 374 treatments with antimicrobials were recorded, 62.8% (235/3…
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November 28th, 2018
Vía publiDB
Spatio-temporal epidemiology of anthrax in Hippopotamus amphibious in Queen Elizabeth Protected Area, Uganda
Investigation published in PLoS ONE
Background
Anthrax is a zoonotic disease primarily of herbivores, caused by Bacillus anthracis, a bacterium with diverse geographical and global distribution. Globally, livestock outbreaks have declined but in Africa significant outbreaks continue to occur with most countries still categorized as enzootic, hyper endemic or sporadic. Uganda experiences sporadic human and livestock cases. Severe large-scale outbreaks occur periodically in hippos (Hippopotamus amphibious) at Queen Elizabeth Protected Area, where in 2004/2005 and 2010 anthrax killed 437 hippos. Ecological drivers of these outbrea…
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November 28th, 2018
Vía publiDB
Evaluation of the McLintock syringe as a cause of non-specific reactions in the intradermal tuberculin test used for the diagnosis of bovine tuberculosis
Investigation article published in Research in Veterinary Science
The objective of this study was to elucidate whether the use of the McLintock syringe, used to inject tuberculin in cattle in several countries and based on an intradermal inoculation by needle, may, in itself, cause skin reactions that can be interpreted as positive reactions regardless of the real tuberculosis (TB) infection status of the animals.
Forty-four cattle from an officially TB-free (OTF) herd were selected for the experiment. Each animal received four inoculations [one with sterile phosphate buffer saline (PBS) with 10% of glycerol and three with bovine purified protein derivative…
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November 21st, 2018
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Development and characterization of mouse monoclonal antibodies to eight human complement components: analysis of reactivity with orthologs of nine mammalian genera
Comparative Immunology, Microbiology and Infectious Diseases publish this investigation article
Abstract
To study complement function in mammalian leishmanioses, we developed mouse monoclonal antibodies to the human complement system components C1q, C4, factor D, factor H, factor B, properdin, C5 and C9. Antibody specificity was determined by indirect and capture ELISA and by Western blot. In flow cytometry analysis, seven antibodies recognized the cognate component on human serum-opsonized Leishmania promastigotes. Antibody reactivity was screened against promastigotes opsonized with sera of nine mammalian genera: pig, guinea pig, goat, rabbit, cat, dog, hamster, jird and rat. No antib…
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November 1st, 2018
Vía publiDB
Rapid differentiation of Staphylococcus aureus subspecies based on MALDI-TOF MS profiles
Investigation published in Journal of Veterinary Diagnostic Investigation
Staphylococcus aureus encompasses 2 subspecies ( aureus and anaerobius) with significant differences in their epidemiology and pathogenicity. We evaluated the suitability of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the rapid identification of both subspecies using a panel of 52 S. aureus isolates (30 subsp. anaerobius and 22 subsp. aureus) recovered from different origins, countries, and years. The on-board library identification system correctly identified 42 of 52 (81%) S. aureus isolates at the species level with score values >2.0. Limi…
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