Research

Budd-Chiari-like pathology in dolphins

Scientific reports publish this investigation article

Nearly two decades ago, pathologic examination results suggested that acoustic factors, such as mid-frequency active naval military sonar (MFAS) could be the cause of acute decompression-like sickness in stranded beaked whales. Acute systemic gas embolism in these whales was reported together with enigmatic cystic liver lesions (CLL), characterized by intrahepatic encapsulated gas-filled cysts, tentatively interpreted as "gas-bubble" lesions in various other cetacean species. Here we provide a pathologic reinterpretation of CLL in odontocetes. Among 1,200 cetaceans necropsied, CLL were only ob… Leer más

Hepatitis E in the pig production chain: from farm to fork

PhD Thesis defense by Alejandro Navarro Gómez at the Faculty of Veterinary Medicine of the Complutense University of Madrid

Hepatitis E (HE) is one of the main acute viral hepatitis worldwide, and can represent an important problem in Public Health. The virus responsible for this disease is the hepatitis E virus (HEV), belonging to the Hepeviridae family. To date, 8 different genotypes of HEV are known. The genotypes that affect humans are genotypes 1-4, although the possible zoonotic potential of genotypes 5, 7 and 8 has been described. In developed countries, the causes of HE in humans are genotype 3 and 4, generally associated with the consumption of contaminated and under cooked food. The main animal reservoir … Leer más

- Piden implantar medidas de vigilancia frente a la hepatitis E en el porcino de España - animalshealth.es

Zoonosis in wild ruminants and wild boars in the Region of Madrid

Silvia Úbeda Jiménez defended this Degree Final Project

Los patógenos infecciosos presentes en la fauna silvestre han adquirido una importancia creciente en nuestra sociedad ya que tienen un impacto trascendente sobre la Salud Pública por su capacidad de transmitirse a los humanos, lo que se conoce como zoonosis, y por ello es necesario llevar una adecuada vigilancia y control de estas enfermedades. El objetivo de este estudio es determinar la prevalencia de diferentes patógenos zoonósicos de relevancia en rumiantes salvajes y jabalíes en la Comunidad de Madrid durante el año 2021, enmarcados en el sistema de Vigilancia de fauna silvestre de esta r… Leer más

Evaluación del efecto de la administración parenteral de AINEs y glucocoticoides en las pruebas de diagnóstico oficial de tuberculosis bovina en un modelo experimental caprino

Carlos Velasco Reinaldos defended this Degree Final Project

El rendimiento de las pruebas de diagnóstico de la tuberculosis (TB) en los rumiantes domésticos se puede ver afectado por diferentes factores. El objetivo del presente estudio fue evaluar si la aplicación fraudulenta vía parenteral de ketoprofeno (antiinflamatorio no esteroideo o AINE) o de dexametasona (glucocorticoide) en el ganado puede provocar interferencias en la prueba de diagnóstico oficial, la intradermotuberculinización (IDTB). El modelo animal experimental elegido para el estudio fue el caprino. Se seleccionaron aleatoriamente 90 animales de un rebaño de aptitud lechera con una pr… Leer más

Histopathological and immunohistochemical study of premature senescence of cells in forensic cases of dogs starvation due to animal abuse

Degree Final Project defended by Esther Vázquez Fernández

Animal abuse is of mayor concern in today`s society, with an increasing number of reported cases. Violence towards animals is considered an additional factor of interpersonal violence, making essential to advance in the field of forensic veterinary pathology. Starvation, the involuntary loss of body mass, is one of the main causes of death in cases of animal abuse. Starvation is due to a catabolic state that induce atrophy in most organs. However, the mechanism beyond atrophy is not fully understood. The aim of this research is to retrospectively study a series of dog forensic cases diagnosed … Leer más

Corynebacterium conjunctivae: A New Corynebacterium Species Isolated from the Ocular Surface of Healthy Horses

Investigation published in Animals

Twenty-two unidentified Gram-positive, rod-shaped organisms were recovered from the conjunctival surface of apparently healthy horses and subjected to a polyphasic taxonomic analysis. Based on cellular morphology and biochemical criteria, the isolates were tentatively assigned to the genus Corynebacterium, although they did not match any recognized species. Comparative 16S rRNA gene sequencing studies demonstrated that all of the isolates were phylogenetically members of the genus Corynebacterium. The isolates shared 99.4 to 100% 16S rRNA gene sequence similarity among the strains and 96.5% si… Leer más

Use of Whole-Genome Sequencing to Unravel the Genetic Diversity of a Prevalent Mycobacterium bovis Spoligotype in a Multi-Host Scenario in Spain

Investigation published in Frontiers in Microbiology

Despite the efforts invested in the eradication of bovine tuberculosis in Spain, herd prevalence has remained constant in the country during the last 15 years (~1.5–1.9%) due to a combination of epidemiological factors impairing disease control, including between-species transmission. Here, our aim was to investigate the molecular diversity of Mycobacterium bovis isolates belonging to the highly prevalent SB0339 spoligotype in the cattle-wildlife interface in different regions of Spain using whole-genome sequencing (WGS). Genomic data of 136 M. bovis isolates recovered from different ani… Leer más

Good and bad get together: Inactivation of SARS-CoV-2 in particulate matter pollution from different fuels

Investigation article published in Science of the total environment

Air pollution and associated particulate matter (PM) affect environmental and human health worldwide. The intense vehicle usage and the high population density in urban areas are the main causes of this public health impact. Epidemiological studies have provided evidence on the effect of air pollution on airborne SARS-CoV-2 transmission and COVID-19 disease prevalence and symptomatology. However, the causal relationship between air pollution and COVID-19 is still under investigation. Based on these results, the question addressed in this study was how long SARS-CoV-2 survives on the surface of… Leer más

- ¿Cuánto tiempo sobrevive el SARS-CoV-2 en la superficie de diferentes partículas de contaminación? - portalveterinaria.com

- Una investigación científica revela que las emisiones de los motores inactivan el SARS-CoV-2, pero “hay un lado malo” - eldiario.es

- Contaminantes urbanos y virus SARS-CoV-2 - irec.es

Puesta a punto y optimización de PCR a tiempo real para vibrio spp

Degree Final Project defended by Andrea Marcos Baqueiro

Detection of bacteria of the genus Rickettsia in ticks and development of a high resolution melting technique

Degree Final Project defended by Gonzalo Pérez Serrano

Ricekttsioses are a group of emerging zoonotic pathologies caused by bacteria of the genus Rickettsia. These bacteria are Gram-negative, intracellular bacillococci, and the diseases they produce are transmitted to vertebrates by vectors such as ticks, mites, fleas and lice. Due to their highly conserved genome, there are limitations in the identification of the different species of rickettsiae. In this work, the molecular detection of bacteria of the genus Rickettsia in ticks has been carried out by performing conventional PCR and sequencing of the ompA and ompB genes, which is a laborious and… Leer más