Last scientific dissertations
July 4th, 2024
Vía publiDB
Evaluation of alternative antigens to PPDs for the diagnosis of caprine tuberculosis
Alberto Corroto Martín defended this Degree Final Project
Improving the sensitivity (Se) and specificity (Sp) performance of official tuberculosis (TB) tests in goats is crucial as their limited performance leads to the existence of false positives and false negatives, with the associated economic, health and confidence implications. Therefore, great efforts have been devoted to the search and evaluation of new antigens that can replace classical PPDs, such as bovine PPD (PPDb) and avian PPD (PPDa), in order to improve the performance of official TB ante-mortem diagnostic tests.
This study focuses on evaluating two new antigens, DST-F and P22, as re…
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July 4th, 2024
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Detection of Crimean-Congo hemorrhagic fever virus in ticks obtained from wild animals
Degree Final Project defended by Inés Higueras Fernández
The Crimean-Congo Hemorrhagic Fever (CCHF) is an infectious and zoonotic disease of viral etiology, transmitted by ticks of the genus Hyalomma. The increase in positive cases of in Spain since its first detection in 2010, along with the rising number of positive ticks detected, suggests the need for more thorough control over the actual circulation of this virus in the country. To date, various studies have been conducted focusing on detecting the circulation of CCHFV in regions of the national territory with a history of positive cases, omitting those areas where such precedents did not exist…
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July 4th, 2024
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Estudio histopatológico e inmunohistoquímico en cerdos infectados por la cepa Pol/DP/OUT21 de peste porcina africana
Javier de Pablo Moreno defended this Degree Final Project
El virus de la peste porcina africana (PPA) induce una enfermedad letal tanto en cerdos domésticos como salvajes, provocando graves pérdidas económicas en la producción porcina. Las cepas que afectan actualmente a Europa pertenecen al genotipo II. Por tanto, es necesario realizar estudios patogénicos con diferentes cepas de PPA, debido a la variabilidad entre ellas. Se realizó un estudio anatomopatológico completo en 12 cerdos infectados por la cepa del virus de la PPA Pol16/DP/OUT21 con puntuaciones tanto macroscópicas como histológicas. El cuadro agudo-subagudo que indujo es compatible con l…
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June 17th, 2024
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Evaluación de la resistencia antimicrobiana en Salmonella y Escherichia coli en alimentos en puestos de control fronterizo de España (2021-2023)
Elena Fernández Cabrera defended this presentation at the Faculty of Veterinary Medicine of the Complutense University of Madrid in order to obtain the Master of Research
Escherichia coli y Salmonella son dos microorganismos pertenecientes a la familia Enterobacteriaceae que forman parte de la microbiota intestinal comensal de la mayoría de mamíferos, aunque también existen cepas patógenas capaces de causar infecciones. Estas bacterias pueden presentar una gran diversidad de mecanismos de resistencia antimicrobiana, siendo la producción de betalactamasas de espectro extendido (BLEEs) y betalactamasas tipo AmpC los más comunes y, en menor medida, las carbapenemasas, que a su vez es el mecanismo más preocupante. Estas enzimas confieren resistencia a los betalactá…
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June 12nd, 2024
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New perspectives in the study of mayor emerging diseases in cetaceans: advances in the understanding of Herpesviruses, Morbilliviruses and Brucella
PhD Thesis defense by Ignacio Vargas Castro at the VISAVET Centre of the Complutense University of Madrid
The importance of cetacean conservation in scientific research is increasingly prominent, giving rise to growing global concern due to the extinction threat faced by several cetacean species. The protection and preservation of these animals benefit the entire marine ecosystem, as they are considered umbrella species. Furthermore, their charisma and popularity make them flagship species, playing a significant role in raising awareness and promoting conservation among the general public. Additionally, they serve a crucial function as sentinels of ocean health.
On the other hand, the "One Heal…
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June 6th, 2024
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Study of factors affecting the diagnostic performance of cellular and humoral-based techniques for caprine tuberculosis
PhD Thesis defense by Javier Ortega Martín at the VISAVET Centre of the Complutense University of Madrid
Caprine tuberculosis (TB) is a zoonotic mycobacteriosis caused by members of the Mycobacterium tuberculosis complex (MTBC), mainly M. caprae and M. bovis. Due to its health and economic impact, this disease is subject to surveillance and eradication programs. In Spain, certain regions have been established specific eradication programs for those caprine herds epidemiologically related to cattle herds. In addition, caprine TB eradication programs have been implemented in some Autonomous Communities, also included in a specific manual of the Ministry of Agriculture, Fisheries and Food of Spain i…
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May 22nd, 2024
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Patología y causas de varamiento en tortugas marinas de la Comunidad Valenciana
PhD Thesis defense by José Luis Crespo Picazo at the VISAVET Centre of the Complutense University of Madrid
The aim of this thesis is to apply epidemiological surveillance as a fundamental tool to learn about the occurrence of diseases and causes of death in a population in a given area, to monitor them over time and to propase control or mitigation strategies in management plans. In the case of the Valencian Community, as in many other regions at national and international level, a complete study of the pathologies and causes of death of sea turtles has not yet been carried out. This thesis is an ordered, systematic and complete study of the sea turtles that appeared in the Valencian Community duri…
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April 26th, 2024
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Characterization of Oxidative Stress Biomarkers in Dogs: Reference Intervals, Biological Variation Sources, and Endogenous Interferences
PhD Thesis defense by Blanca Pérez Montero at the VISAVET Centre of the Complutense University of Madrid
Oxidative stress, defined as an imbalance between oxidizing agents and the antioxidant forces of the body, has been associated with multiple pathologies in the canine species. Among the most commonly used biomarkers are malondialdehyde (MDA), a metabolite of lipid peroxidation, 8-hydroxy-2`-deoxyguanosine (8-OHdG), a product of DNA oxidation, and the 2,2`-azino-bis-[3-ethylbenzothiazoline-6-sulfonic acid] (ABTS) assay as an indicator of total antioxidant status (TAS). Although these biomarkers have demonstrated clinical value in dogs, the absence of established reference intervals (RIs) is not…
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April 4th, 2024
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Evolutionary Dynamics of Integron Resistance Cassettes. A Deeper Look into the Integron Model
PhD Thesis defense by Alberto Hipólito Carrillo de Albornoz at the Faculty of Veterinary Medicine of the Complutense University of Madrid
Antimicrobial resistance is one of the major global health concerns of the 21st century. The indiscriminate use of antibiotics, among other factors, has led to an exponential increase in antimicrobial- resistant bacteria in recent decades. It is estimated that every year between 1.5 and 5 million people die due to infections caused by multidrug-resistant bacteria. These data highlight the need to take urgent measures to tackle this threat, with a priority on understanding the forces that govern the success of multidrug-resistant bacteria.
The exceptional ability of bacteria to evolve and ad…
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March 21st, 2024
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Strategies for African swine fever prevention
PhD Thesis defense by Carolina Muñoz Peréz at the VISAVET Centre of the Complutense University of Madrid
African swine fever (ASF) is a devastating infectious disease of swine, which is listed as notifiable to the World Organisation for Animal Health (WOAH). In the last few years, the disease has spread worldwide. Nowadays, this pandemic spread poses the greatest threat to the global swine industry. In view of this situation, this doctoral thesis entitled: “Strategies for African swine fever prevention”, aims to develop epidemiological knowledge regarding the most important risk factors for ASF entry into an ASF-free area, in particular, the natural movement of wild boar populations and the inter…
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