Last scientific dissertations
January 18th, 2024
Vía publiDB
Immunological aspects of ovine pulmonary tuberculosis: histological and immunohistochemical study
Degree Final Project defended by Enni Amanda Ramirez Vuori
Mycobacterium tuberculosis complex (MBC) species are capable of infecting a wide range of hosts, including sheep, which can act as reservoirs. Our objective was to characterize histologically and immunohistochemically the pulmonary granulomas caused by three species of MTC (M. bovis, M. caprae and M. tuberculosis) in sheep (Ovis orientalis aries). Twelve animals experimentally inoculated via hematogenous route were included in a retrospective study. Granulomas were classified, quantified and described using hematoxylin-eosin and Masson`s trichrome stains. Histological study of the lesions reve…
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November 14th, 2023
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Brucellosis (Brucella suis, B. ovis, B. ceti) in domestic animals and wildlife: New aspects of epidemiology, immune response, and pathology
PhD Thesis defense by Agustín Miguel Rebollada Merino at the VISAVET Centre of the Complutense University of Madrid
Brucellosis (Brucella spp.) is a reemerging zoonotic notifiable disease. It is subject to surveillance, control, and eradication programs worldwide. Most Member States of the European Union are considered free of the disease, but brucellosis is endemic in developing countries, limiting their economy, and causing disease in humans. Despite the relevance of many of these Brucella species, there are some unknown aspects. The main objective of this PhD Thesis has been to explore new aspects of the epidemiology, immune response, and pathology of Brucella infection in domestic and wild animals to im…
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October 2nd, 2023
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Identification and characterization of colistin resistant bacteria from food-producing animals in Spain. Assessment of its persistance and possible dissemination
PhD Thesis defense by Pedro Miguela Villoldo at the VISAVET Centre of the Complutense University of Madrid
Colistin is a cationic polypeptide whose use as antibiotic was withdrawn since the 1970s because of its toxicity, but was reintroduced later in human medicine to treat infections caused by multi-resistant Gram-negative bacteria, being categorised as a "last resort antimicrobial". Colistin has been used in veterinary medicine since its discovery for the treatment of infections in animals, especially post-weaning diarrhoea caused by E. coli in piglets and calves and colibacillosis in poultry.
Traditionally, colistin was linked exclusively to chromosome mutations in the two-component systems g…
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September 18th, 2023
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Persistence of equine herpesvirus type 1 in urine
Abel Dorrego Rodríguez defended this presentation at the Faculty of Veterinary Medicine of the Complutense University of Madrid in order to obtain the Master of Research
Equine herpesvirus type 1 is a highly contagious virus distributed globally that causes
respiratory, reproductive, and neurological disease in horses. It often presents itself in the form of outbreaks where rapid diagnosis is essential. The description of the virus`s presence in urine opens the door to its use as a diagnostic sample. This study was conducted in order to understand the behaviour of the virus in this fluid and to establish the most suitable preservation method. The virus was artificially inoculated into samples from 6 horses, assessing how the concentration varied over time and…
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September 14th, 2023
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Evaluation of diagnostic tests for the detection of tuberculosis in cervids
Mónica Alonso Fernández defended this Degree Final Project
Tuberculosis is one of the infectious diseases with the greatest impact worldwide, caused by bacteria of the Mycobacterium tuberculosis complex, capable of affecting both humans and animals. The first actions to establish control of bovine tuberculosis in Spain started in the middle of the 20th century, which has led to a decrease in the incidence and prevalence in animals. Wildlife is an important reservoir for domestic cattle, which makes eradication difficult. Cervids are one of the main reservoirs of tuberculosis for cattle, especially red deer (Cervus elaphus) and fallow deer (Dama dama).…
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September 14th, 2023
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Surveillance of zoonotic pathogens in wild birds in the Community of Madrid
Daniel Peromingo Fernández defended this Degree Final Project
Wild birds are important reservoirs of zoonotic pathogens, although the risk of transmission to humans is quantitatively lower than for other mammalian host groups, due to their phylogenetic distance. The main epidemiological determinants of wild birds in relation to zoonoses include migratory movements and their association with emerging and re-emerging diseases, and their ability to adapt to urban environments, which is associated with increased exposure to humans. Both psittacosis and West Nile fever are zoonoses of great public health relevance and share their reservoir in birds. The aim o…
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September 6th, 2023
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New approaches in the control of infectious fertility problems in extensive cattle
PhD Thesis defense by Coral Polo Vaquero at the VISAVET Centre of the Complutense University of Madrid
In Spain, extensive cattle farming is a sector characterized by its priority orientation towards beef production and whose main objective from a productive point of view is to maximize the number of calves per cow and year. Extensive exploitation systems may be able to use the natural resources of the environment, contributing to the maintenance of resilient ecosystems as long as they are properly managed. In 2020, Spain generated the 24 % of beef within the European Union (EU), being the third main beef producing country. However, the average annual fertility rates of this sector in Spain is …
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July 20th, 2023
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Epidemiology of Extended-Spectrum Beta-Lactamase (ESBL) and AmpC-Producing E. coli in Production Animals in Spain During the Period 2014-2018
Degree Final Project defended by Irene del Corral Medina
Escherichia coli is a microorganism found as part of the commensal intestinal microbiota of mammals but can also cause infections with clinical consequences. This bacterium can harbor a large diversity of antimicrobial resistance mechanisms, with the production of extended-spectrum beta-lactamases (ESBL), AmpC beta-lactamases, and carbapenemases being among the most concerning. These enzymes confer resistance to beta-lactams, one of the most widely used antimicrobial families in human and veterinary medicine. The increasing presence of ESBL/AmpC-producing E. coli in humans and animals has led …
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June 20th, 2023
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Evaluation of the effect of recent intradermal tuberculin test on the specific humoral-based response in milk samples from tuberculosis-free goats
Degree Final Project defended by Jaime Ricón Fernández de la Puente
Goat tuberculosis (TB) is a disease with a significant economic and health impact, subject to control and eradication programs in some areas of the Spanish territory, which employ diagnostic tests such as single or comparative intradermal tuberculin (SIT and CIT respectively) tests) and occasionally, the interferon-gamma test (IGRA). These plans are based on the detection and slaughter of positive animals; however, diagnostic tests have limitations, and new techniques have been sought to increase their specificity (Sp) and sensitivity (Se). One of these techniques is the P22 ELISA, a humoral-b…
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January 20th, 2023
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New Methodologies for the Diagnosis of Bovine Tuberculosis
PhD Thesis defense by Víctor Lorente Leal at the VISAVET Centre of the Complutense University of Madrid
Bovine tuberculosis (bTB) is a serious infectious disease of bovids that is subjected to eradication programmes around the world due to its negative effect in animal health and production, as well as its zoonotic potential. Despite the great advances in the eradication of the disease, bTB is still an ongoing problem in certain regions of the EU and Spain. The main objective of this doctoral thesis was the development of novel diagnostic and characterisation tools that can contribute in enhancing the efficiency of the eradication efforts. This was achieved through the development of sensitive a…
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