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December 2nd, 2024

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The Veterinary quarterly

A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats

Investigation article published in The Veterinary quarterly


Caprine livestock are significant reservoirs of the Mycobacterium tuberculosis complex (MTBC), contributing to tuberculosis (TB) transmission among animals and humans. The P22 protein immunocomplex (P22PI), derived from bovine tuberculin, shows immunostimulating capacity and is used for TB diagnosis. This study assessed the immunogenicity and protective efficacy of P22PI in two groups of goats: 24 naïve goats (12 immunised, 12 controls) from a TB-free herd, and 24 infected goats (12 immunised, 12 controls), referred to as pre-infected animals, from a M. bovis-infected herd. Both were exposed f… Read more




November 29th, 2024

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Veterinary Microbiology

Immunological mechanisms involved in the protection against development of pulmonary tuberculosis in naturally infected goats

Investigation article published in Veterinary Microbiology


Tuberculosis (TB) is a notifiable zoonotic disease caused by bacteria of the Mycobacterium tuberculosis complex (MTBC) that affects a multitude of domestic and wild species. The main lesions caused by these mycobacteria are tuberculous granulomas, which determine the organism`s immune response to the disease. Although TB pathogenesis in cattle has been extensively studied, information regarding its progression in other species of interest for the maintenance and transmission of TB such as goats remains limited. This study aimed to characterise the immune response developed in the lungs of goat… Read more




November 23rd, 2024

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Curso de formación en los aspectos teóricos, prácticos y de base legal en el diagnóstico de la tuberculosis bovina. 28ª edition

Communications in this event:


- Resultado individuales y colectivos de la validación de la prueba de la tuberculina. Recomendaciones y plan de acción

- Traslado al cebadero. Jornada práctica. Realización de la prueba de IDTB. Parte 1: Rasurado, 1ª lectura e inuculación intradérmica de la PPDs. Parte 2: Interpretación de la prueba. Validación individual de la prueba práctica

- Interferencia diagnóstica en la tuberculosis. Estudios de sensibilidad y especificidad

- Control de la tuberculosis. Importancia de los animales salvajes como reservorio de la tuberculosis. La vacunación como herramienta de control de la tuberculosis

- Actividades del EU-RL for Bovine Tuberculosis

- Pruebas de diagnóstico de la tuberculosis basadas en la respuesta inmune: intradermotuberculinización, detección de interferón-gamma y serología para la detección de anticuerpos

- Epidemiología molecular de la tuberculosis. Aplicación práctica de la base de datos mycoDB.es

- Estudios epidemiológicos en la explotación/zona. Las encuestas epidemiológicas

- Diagnóstico microbiológico de la tuberculosis. Identificación del agente etiológico. Manual y normativa aplicable. Toma de muestras

- Aspectos generales de la inmunología de la tuberculosis. Respuesta inmune natural y adquirida. Diagnóstico anatomopatológico de la tuberculosis. Estudio de las lesiones macroscópicas e histológicas. Descripción del cuadro lesional



November 21st, 2024

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Eurosurveillance

Escherichia coli from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020

Eurosurveillance publish this investigation article


BackgroundAntimicrobial resistance (AMR) is a global threat. Monitoring using an integrated One Health approach is essential to detect changes in AMR occurrence.AimWe aimed to detect AMR genes in pathogenic and commensal Escherichia coli collected 2013-2020 within monitoring programmes and research from food animals, food (fresh retail raw meat) and humans in six European countries, to compare vertical and horizontal transmission.MethodsWe whole genome sequenced (WGS) 3,745 E. coli isolates, detected AMR genes using ResFinder and performed phylogenetic analysis to determine isolate relatedness… Read more




November 20th, 2024

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DISCONTOOLS chapter on bovine tuberculosis

New online article published in Discontools


This Disease and Product Analysis (DPA) is policy neutral; we have adhered to the natural science evidence base. Disease: Mammalian tuberculosis (TB) is a chronic bacterial disease of animals, including humans, caused by host-adapted members of the Mycobacterium tuberculosiscomplex (MTBC). Regarding livestock and wildlife hosts, we refer mostly to infection with M. bovis and other animal-adapted variants, such as M. caprae. World Organisation of Animal Health (WOAH 2022, founded as OIE), EU Bovine TB Task Force sub… Read more




November 15th, 2024

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Oxidative Stress in Canine Diseases: A Comprehensive Review

Investigation published in Antioxidants


Oxidative stress (OS), defined as a disruption in redox balance favoring oxidants, has emerged as a major contributor to numerous diseases in human and veterinary medicine. While several reviews have explored the implication of OS in human pathology, an exhaustive review of the canine species is lacking. This comprehensive review aims to summarize the existing literature on the role of OS in canine diseases, highlighting its potentially detrimental effect on various organs and systems. Some inconsistencies among studies exist, likely due to varying biomarkers and sample types. However, there i… Read more









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