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Last SCI scientific publications

January 1st, 2020

Econometric ARIMA methodology to elucidate the evolution of trends in nosocomial antimicrobial resistance rates in the European Union

International Journal Of Antimicrobial Agents 55(1):105800.

Infectious pathogens harboring cephalosporin or fluoroquinolones resistance constitute a serious hazard to human health.
The aim of this study is to set up a methodology based on econometric analysis and largest European Union (EU) resistance database (EARS-Net) to model EU nosocomial antimicrobial resistance (AMR) and to detect tendency changes, steps or peaks. The contribution of legislation based on third generation cephalosporin (3GC) and fluoroquinolones (FQ) class referrals on EU resistance rate patterns is evaluated.
We studied 3GC and FQ resistance in nosocomial E. coli, K. pneumoniae and P. aeruginosa in at least 25 out of 30 EU countries (> 94% population coverage… Leer más

Ortega-Huedo R., Cuesta M., Hoefer A. and Gonzalez-Zorn B..

December 21st, 2019

Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions

The Veterinary Record 185(24):759.

There is evidence for a link between vitamin D deficiency and active tuberculosis (TB). In human beings, several trials have evaluated the role of vitamin D supplementation in TB treatment with conflicting results. However, the role of vitamin D supplementation in animal TB control has received less attention. The authors evaluated the benefit of vitamin D supplementation for preventing mycobacterial infection or reducing TB lesions (TBL) in a controlled trial with goats naturally exposed to Mycobacterium caprae.
Two groups of goats, a vitamin D-supplemented group and a non-supplemented control group, were housed for 10 months in direct contact with M caprae-infected adult goats. Upon contact … Leer más

Risalde MA., Roy A., Bezos J., Pineda C., Casal C., Diez-Guerrier A., Lopez-Villalba I., Fernandez-Manzano A., Moreno I., de Juan L., Dominguez L. and Gortazar C.

December 16th, 2019

Antimicrobial susceptibility of Pasteurella multocida isolated from sheep and pigs in Spain - Short communication

Acta Veterinaria Hungarica 67(4):489-498.

     Pasteurella multocida is responsible for economically important diseases in sheep and pigs. Antimicrobial susceptibility studies are essential for initiating rational and effective empirical therapy of P. multocida infections. In this study we investigated the antimicrobial susceptibility to 18 antimicrobial agents of 156 clinical isolates of P. multocida from sheep (n = 87) and pigs (n = 69) using the microdilution method. Both sheep and pig isolates exhibited low levels of resistance (≤ 15%) to ceftiofur, gentamicin, neomycin, spectinomycin, chlortetracycline, tulathromycin, florfenicol, danofloxacin, and enrofloxacin and trimethoprim/sulphamethoxazole, high resistance rates (> 15% up to 50%) to oxytetracycline, tilmicosin, and tiam… Leer más

Cid D., Fernandez-Garayzabal JF., Pinto C., Dominguez L. and Vela AI..

December 10th, 2019

Tuberculosis Epidemiology and Badger (Meles meles) Spatial Ecology in a Hot-Spot Area in Atlantic Spain

Pathogens 8(4)292.

     We provide a temporal overview (from 2012 to 2018) of the outcomes of tuberculosis (TB) in the cattle and badger populations in a hot-spot in Asturias (Atlantic Spain). We also study the badger’s spatial ecology from an epidemiological perspective in order to describe hazardous behavior in relation to TB transmission between cattle and badgers. Culture and single intradermal tuberculin test (SITT) were available for cattle as part of the National Program for the Eradication of TB. A field survey was also carried out in order to determine the paddocks and buildings used by each farm, and the information obtained was stored by using geographic information systems. Moreover, eighty-three badgers were submitted for necropsy and subsequent bacte… Leer más

Acevedo P., Prieto M., Quiros P., Merediz I., de Juan L., Infantes-Lorenzo JA., Triguero-Ocana R. and Balseiro A.

December 7th, 2019

Association between results of diagnostic tests for bovine tuberculosis and Johne`s disease in cattle

The Veterinary Record 31554708.

Bovine tuberculosis (bTB) diagnosis is impaired by numerous factors including cross-reactivity with Mycobacterium avium subspecies paratuberculosis, which causes Johne`s disease (JD). In addition, the effect of repeated bTB-intradermal testing on the performance of JD diagnostic tests is not fully understood. This study aimed to evaluate the impact of repeated bTB-intradermal tests under field conditions in Spain on the JD serological status of cattle.

bTB-positive herds (n=264) from Castilla-y-Leon region were selected and matched with officially tuberculosis-free control herds. The association between JD and bTB status at the herd level was assessed using conditional logistic regression an… Leer más

Picasso C., Grau A., Bakker D., Nacar J., Minguez O., Perez A. and Alvarez J..

December 2nd, 2019

Use of a voluntary testing program to study the spatial epidemiology of Johne’s disease affecting dairy herds in Minnesota: a cross sectional study

BMC Veterinary Research 15(1):429.

     One of the key steps in the management of chronic diseases in animals including Johne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is the ability to track disease incidence over space and time. JD surveillance in the U.S. dairy cattle is challenging due to lack of regulatory requirements, imperfect diagnostic tests, and associated expenses, including time and labor. An alternative approach is to use voluntary testing programs. Here, data from a voluntary JD testing program, conducted by the Minnesota Dairy Herd Improvement Association, were used to: a) explore whether such a program provides representative information on JD-prevalence in Minnesota dairy herds, b) estimate JD distribution, and, c) identify her… Leer más

Kanankege KST., Machado G., Zhang L., Dokkebakken B., Schumann V., Wells SJ., Perez AM. and Alvarez J..

December 1st, 2019

Assessment of the sensitivity of the bovine tuberculosis eradication program in a high prevalence region of Spain using scenario tree modeling

Preventive Veterinary Medicine 173:104800.

     In spite of the efforts invested to eradicate bovine tuberculosis (bTB) in cattle, the disease is still present in several developed countries, including Spain. Among the factors related with disease persistence in high prevalence areas, the lack of sensitivity of the screening test for detection of infected herds [single intradermal tuberculin (SIT) test] can play a major role. Here, a scenario tree model mimicking the diagnostic test scheme in place in the region of Castilla y Leon (Spain) was developed to estimate the probability of detecting bTB in an infected-non detected officially tuberculosis free (OTF) herd (herd sensitivity, HSe). In order to do so the probability of detecting at least one positive animal in the SIT test with/with… Leer más

de la Cruz ML., Pozo P., Grau A., Nacar J., Bezos J., Perez A., Dominguez L., Saez JL., Minguez O., de Juan L. and Alvarez J..

December 1st, 2019

Gene pool transmission of multidrug resistance among Campylobacter from livestock, sewage and human disease

Environmental Microbiology 21(12):4597-4613.

     The use of antimicrobials in human and veterinary medicine has coincided with a rise in antimicrobial resistance (AMR) in the food‐borne pathogens Campylobacter jejuni and Campylobacter coli. Faecal contamination from the main reservoir hosts (livestock, especially poultry) is the principal route of human infection but little is known about the spread of AMR among source and sink populations. In particular, questions remain about how Campylobacter resistomes interact between species and hosts, and the potential role of sewage as a conduit for the spread of AMR. Here we investigate the genomic variation associated with AMR in 168 C. jejuni and 92 C. coli strains isolated from humans, livestock and urban effluents in Spain. Antimicrobia… Leer más

Mourkas E., Florez-Cuadrado D., Pascoe B., Calland JK., Bayliss SC., Mageiros L., Meric G., Hitchings MD., Quesada A., Porrero MC., Ugarte-Ruiz M., Gutierrez-Fernandez J., Dominguez L. and Sheppard SK.

November 29th, 2019

A Summer Mortality Outbreak of Lactococcosis by Lactococcus garvieae in a Raceway System Affecting Farmed Rainbow Trout (Oncorhynchus mykiss) and Brook Trout (Salvelinus fontinalis)

Animals 9(12).

     Lactococcosis is a fish disease of major concern in Mediterranean countries caused by Lactococcus garvieae. The most susceptible species is the rainbow trout (Oncorhynchus mykiss), suffering acute disease associated with elevated mortalities compared to other fish species. References reported that other salmonids are also susceptible to the disease, but no mortality outbreak has been described to date. The aim of this study was to present a mortality outbreak that occurred in brook trout (Salvelinus fontinalis) farmed in northwestern Italy during the summer of 2018. Fish exhibited clinical signs, such as exophthalmos, diffused hemorrhages localized in the ocular zone, hemorrhagic enteritis, and enlarged spleen. L. garvieae was isolated in a… Leer más

Pastorino P., Vela AI., Colussi S., Cavazza G., Menconi V., Mugetti D., Righetti M., Barbero R., Zuccaro G., Fernandez-Garayzabal JF., Dondo A., Acutis PL. and Prearo M.

November 27th, 2019

Diarrheagenic Escherichia coli Pathotypes From Children Younger Than 5 Years in Kano State, Nigeria

Frontiers In Public Health 7:348.

     Diarrheagenic Escherichia coli (DEC) is one of the leading causes of gastrointestinal disorders worldwide and an important public health challenge. DEC infection is often underdiagnosed during routine microbiological analysis, especially in resource constrained settings; the use of molecular tests could however help to determine the distribution of DEC and its clinical significance. Here, a study to assess the prevalence of DEC in clinical samples from patients <5 years attending three hospitals in Kano state, Nigeria, was carried out. Samples from 400 patients and 50 controls were collected and screened for E. coli. Compatible colonies from 248 individuals (215 patients and 33 controls) were characterized using biochemical test, a set of r… Leer más

Saka, K.H., Dabo NT., Muhammad B., Garcia-Soto S., Ugarte-Ruiz M. and Alvarez J..

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