Investigación

Peste porcina africana en jabalí: caracterización histopatológica e inmunohistoquímica comparativa entre cepas atenuadas y virulentas del genotipo II

Tesis Doctoral defendida por Néstor Porras González en el Centro VISAVET de la Universidad Computense de Madrid

La peste porcina africana (PPA) es una enfermedad viral altamente letal que afecta a suidos domésticos y silvestres, con una capacidad de diseminación transfronteriza que la convierte en una de las principales amenazas para la sanidad animal y la economía de la producción porcina a nivel mundial. Su irrupción en el continente europeo y la propagación sostenida en poblaciones de jabalí euroasiático (Sus scrofa) han situado a este hospedador en el centro de la epidemiología de la enfermedad. El presente trabajo se centra en el genotipo II del virus de la PPA (vPPA), actualmente responsa… Leer más

Estimating the velocity and direction of African Swine Fever spread in wild boar populations in South Korea using Trend-Surface Analysis

PLoS ONE publica este artículo de investigación

African swine fever (ASF) is a lethal disease of swine that has spread across Asia since its introduction in 2018. South Korea first reported the disease in September 2019 in domestic pigs, and since then, more than 4,000 cases have been reported in wild boars during its expansion up to August 2024. Due to the high number of ASF notifications in wild boars in South Korea, contrasted with their scarcity in most Asian countries, analyzing the spatiotemporal spread of the disease in a setting with active surveillance provides valuable insights. In this study, we performed a trend-surface analysis… Leer más

- Científicos españoles descubren la sorprendente velocidad a la que se propaga la peste porcina en jabalíes - revistajaraysedal.es

Éxito de colaboración internacional en una innovadora investigación que revela riesgos de transmisión de tuberculosis entre humanos y grandes simios africanos

Una innovadora metodología de muestreo ambiental revela un preocupante vínculo epidemiológico

Un equipo internacional de investigadores ha publicado recientemente en la revista Emerging Microbes & Infections un estudio pionero que demuestra la presencia de ADN ambiental de Mycobacterium tuberculosis, causante de la tuberculosis humana, en entornos de gorilas en libertad en la República Democrática del Congo.… Leer más

Development of an in situ hybridization assay for the diagnosis of Mycobacteriaceae infections of veterinary importance

Investigación publicada en Veterinary Pathology

Mycobacteria (Mycobacteriaceae family) comprise five genera (Mycobacterium, Mycolicibacterium, Mycolicibacter, Mycolicibacillus, and Mycobacteroides), which include relevant animal and human pathogens. Histology is a rapid method for preemptively diagnosing mycobacteriosis, contributing to surveillance, control, and eradication. A constraint on histology is the limited sensitivity and specificity of acid-fast stains, as the number of detectable bacilli in formalin-fixed paraffin-embedded (FFPE) tissue varies and other microorganisms are acid-fast positive. Immunohistochemistry has low specific… Leer más

Histological and Immunohistochemical Characterization of a Histiocytic Sarcoma Associated With a Follicular Lymphoma in a Ring-tailed Lemur (Lemur catta)

Veterinary Medicine and Science publica este artículo de investigación

A 20-year-old neutered male ring-tailed lemur (Lemur catta) diagnosed with an intrathoracic mass died during surgical excision. Morphological characteristics of the mass during necropsy were consistent with a mediastinal abscess in the left hemithorax. Histological examination identified a disseminated histiocytic sarcoma involving spleen, kidneys, multiple lymph nodes, diaphragm and parietal pleura, as well as a concurrent follicular lymphoma in a separate lymph node. A mixed metastatic infiltrate composed of both neoplasms was found within the capsule of the intrathoracic abscess. Immunohist… Leer más

Exploring specific biomarkers in blood for in vitro diagnosis of caprine tuberculosis

Frontiers in Microbiology publica este artículo de investigación

Introduction: Caprine tuberculosis (cTB) is a zoonotic disease with significant implications for animal and public health and economic impact. Therefore, accurate ante-mortem diagnosis is essential. Diagnosis in goats rely on the single and comparative intradermal tuberculin test (SITT and CITT, respectively), both of which showing limited diagnostic performance. The aim of the study was to characterize the immune and physiological responses to cTB in naturally infected goats and to identify potential in vitro biomarkers that could improve the reliability of cTB diagnosis. Methodology: The s… Leer más

First detection of canine distemper virus infection in variegated squirrels (Sciurus variegatoides) and porcupines (Coendou mexicanus) in Costa Rica

Artículo de investigación publicado en Veterinary Pathology

Canine distemper virus (CDV) is a multi-host pathogen capable of infecting a wide range of domestic and wild mammals, however, reports of infection in squirrels and porcupines remain scarce. As part of the wildlife rabies surveillance programme in Costa Rica, six wild ammals (four Sciurus variegatoides and two Coendou mexicanus) with neurological signs were evaluated to rule out rabies. All brain samples tested negative for rabies by direct immunofluorescence and RT-PCR. Rapid distemper antigen tests of ocular and nasal secretions were positive in both porcupines, which were subsequently eutha… Leer más

Editorial: One Health approach to mycobacterial infections in veterinary science

Investigación publicada en Frontiers in veterinary science

Mycobacteria are ubiquitous pathogens that affect livestock, companion animals, wildlife, and humans, posing major challenges for veterinary medicine. Accurate diagnosis and targeted treatment are crucial to prevent antimicrobial resistance, yet integrated actions across the human–animal–environment interface remain limited, highlighting the need for a One Health approach (1, 2). This Research Topic compiles 11 articles that advance the One Health understanding of veterinary-relevant mycobacteria by examining their epidemiology, diagnosis, treatment, zoonotic transmission dynamics, and … Leer más

Epidemiología cuantitativa para la caracterización del rendimiento de las pruebas diagnósticas utilizadas en el Programa Nacional de Erradicación de la Tuberculosis Bovina

Tesis Doctoral defendida por Alberto Gómez Buendía en el Centro VISAVET de la Universidad Computense de Madrid

La tuberculosis bovina (TB), enfermedad zoonótica de declaración obligatoria causada por bacterias del complejo Mycobacterium tuberculosis, representa un riesgo significativo para la salud pública y animal. De acuerdo con el marco normativo de la Unión Europea los Estados miembros deben implementar programas de control, vigilancia y erradicación, lo que ha permitido que varios países alcancen este último objetivo y eliminen la enfermedad. A pesar de ello, España aún no ha logrado la erradicación completa a pesar de los esfuerzos realizados. No obstante, numerosas provincias han obten… Leer más

Ineffective oral immunization of wild boar with the attenuated African swine fever virus NH/P68 grown in MA104 cell line

Investigación publicada en The Veterinary Journal

African swine fever (ASF) is a highly contagious and lethal hemorrhagic disease affecting domestic pigs and wild boar, with serious consequences for animal health, the swine industry, and socio-economic stability. Given the lack of effective treatments and the limited success of conventional control measures, live attenuated vaccines (LAVs) have emerged as the most promising option, particularly for oral administration in free-ranging wild boar. The naturally attenuated genotype I isolate NH/P68 has shown protective potential in domestic pigs but retains residual virulence and persistence risk… Leer más