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Últimas noticias de Investigación
28 de febrero de 2023
Vía publiDB
A Maximum Entropy Species Distribution Model to Estimate the Distribution of Bushpigs on Madagascar and Its Implications for African Swine Fever
Investigación publicada en Transboundary and Emerging Diseases
Bushpigs (Potamochoerus larvatus) play a major role in the socio-ecosystem of Madagascar, particularly in rural areas. They are largely hunted by rural populations as a major source of income and protein. They can also represent a potential source of pathogens for domestic animals and people. For example, it is hypothesized that bushpigs might compromise African swine fever (ASF) eradication programs by sporadically transmitting the virus to domestic pigs. However, available knowledge on the distribution of bushpigs in Madagascar is limited. In this study, we estimated the distribution of bush…
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28 de febrero de 2023
Vía publiDB
Mycobacterium bovis in Egyptian mongoose, Spain
Zoonoses and Public Health publica este artículo de investigación
Tuberculosis caused by Mycobacterium bovis and other related mycobacteria has been reported in a wide range of mammals worldwide. In the case of the Herpestidae family, Mycobacterium mungi and M. bovis, both belonging to the Mycobacterium tuberculosis Complex, have been reported in banded mongooses (Mungos mungo) in Africa and in Egyptian mongooses (Herpestes ichneumon) in Portugal, respectively. Thus, we hypothesized that Tuberculosis may occur in Egyptian mongooses from Spain. Twenty-five found dead Egyptian mongooses were necropsied in order to detect macroscopic TB-compatible lesions and m…
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22 de febrero de 2023
Vía publiDB
Development of an Effective Oral Vaccine Dissemination Strategy against Classical Swine Fever for Wild Boar in Gifu Prefecture, Japan
Artículo de investigación publicado en Transboundary and Emerging Diseases
In September 2018, classical swine fever (CSF) reemerged in Japan after more than a quarter of a century. After the first notification on a pig farm, wild boars positive for CSF were found continuously in the surrounding area. Gifu was the first prefecture in Japan to disseminate oral vaccines to wild boars in March 2019, with vaccines spread to approximately 14,000 sites between 2019 and 2020. While these diligent measures seemed to have shown some effectiveness, several vaccine spray sites remained without wild boar emergence. Based on the vaccine dissemination records from these periods, th…
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21 de febrero de 2023
Vía publiDB
Accuracy of Tests for Diagnosis of Animal Tuberculosis: Moving Away from the Golden Calf (and towards Bayesian Models)
Investigación publicada en Transboundary and Emerging Diseases
Te last decades have seen major eforts to develop new and improved tools to maximize our ability to detect tuberculosis-infected animals and advance towards the objective of disease control and ultimately eradication. Nevertheless, there is still uncertainty regarding test performance due to the wide range of specifcity and especially sensitivity estimates published in the scientifc literature. Here, we performed a systematic review of the literature on studies that evaluated the performance of tuberculosis diagnostic tests used in animals through Bayesian Latent Class Models (BLCMs), which do…
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20 de febrero de 2023
Vía publiDB
A tool to enhance antimicrobial stewardship using similarity networks to identify antimicrobial resistance patterns across farms
Scientific reports publica este artículo de investigación
Antimicrobial resistance (AMR) is one of the major challenges of the century and should be addressed with a One Health approach. This study aimed to develop a tool that can provide a better understanding of AMR patterns and improve management practices in swine production systems to reduce its spread between farms. We generated similarity networks based on the phenotypic AMR pattern for each farm with information on important bacterial pathogens for swine farming based on the Euclidean distance. We included seven pathogens: Actinobacillus suis, Bordetella bronchiseptica, Escherichia coli, Glae…
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20 de febrero de 2023
Vía publiDB
Differences in skin test reactions to official and defined antigens in guinea pigs exposed to non-tuberculous and tuberculous bacteria
Artículo de investigación publicado en Scientific reports
The single and comparative intradermal tuberculin tests (SITT and CITT) are official in vivo tests for bovine tuberculosis (TB) diagnosis using bovine and avian purified protein derivatives (PPD-B and PPD-A). Infection with bacteria other than Mycobacterium tuberculosis complex (MTC) can result in nonspecific reactions to these tests. We evaluated the performance of the skin test with PPDs and new defined antigens in the guinea pig model. A standard dose (SD) of Rhodococcus equi, Nocardia sp., M. nonchromogenicum, M. monacense, M. intracellulare, M. avium subsp. paratuberculosis, M. avium subs…
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14 de febrero de 2023
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Portable Differential Detection of CTX-M ESBL Gene Variants, blaCTX-M-1 and blaCTX-M-15, from Escherichia coli Isolates and Animal Fecal Samples Using Loop-Primer Endonuclease Cleavage Loop-Mediated Isothermal Amplification
Microbiology Spectrum publica este artículo de investigación
Cefotaximase-Munich (CTX-M) extended-spectrum beta-lactamase (ESBL) enzymes produced by Enterobacteriaceae confer resistance to clinically relevant third-generation cephalosporins. CTX-M group 1 variants, CTX-M-1 and CTX-M-15, are the leading ESBL-producing Enterobacteriaceae associated with animal and human infection, respectively, and are an increasing antimicrobial resistance (AMR) global health concern. The blaCTX-M-1 and blaCTX-M-15 genes encoding these variants have an approximate nucleotide sequence similarity of 98.7%, making effective differential diagnostic monitoring difficult. Loop…
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26 de enero de 2023
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Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice
Aging cell publica este artículo de investigación
The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) signi…
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25 de enero de 2023
Servicio de Informática y Comunicación
El grupo de investigación Vigilancia Sanitaria de la UCM supera su segunda evaluación externa con una calificación de excelente
La Agencia Estatal de Investigación otorga 96 de los 100 puntos posibles al grupo en el 30 aniversario de su creación
El grupo de investigación Vigilancia Sanitaria, adscrito al Centro VISAVET de la Universidad Complutense de Madrid (UCM), ha recibido una calificación de excelente en la segunda evaluación externa por parte de Agencia Estatal de Investigación (AEI) dependiente del Ministerio de Ciencia e Innovación.El grupo, dirigido por el profesor Lucas Domínguez Rodríguez, Catedrático de la UCM, está formado principalmente por investigadores docentes de la Facultad de Veterinaria de la UCM y cuenta entre sus integrantes participantes de otras instituciones como el Instituto de Salud Carlos III, el Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, el Instituto de Investigación en Recursos Cinegéticos, así como las Universidades de Burgos, Extremadura, Minnesota y Europea de Madrid.
30 años dedicados a la vigilancia sanitaria…
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20 de enero de 2023
Vía publiDB
Nuevas metodologías para el diagnóstico de la tuberculosis bovina
Tesis Doctoral defendida por Víctor Lorente Leal en el Centro VISAVET de la Universidad Computense de Madrid
La tuberculosis bovina (TBb) es una enfermedad infecciosa grave de los bóvidos que está sujeta a programas de erradicación en todo el mundo debido a su efecto negativo en la salud y producción animal, así como ser una potencial zoonosis. A pesar de los grandes avances en la erradicación de la enfermedad, la TBb sigue siendo un problema persistente en determinadas regiones de la UE y España. El objetivo principal de esta tesis doctoral fue el desarrollo de nuevas herramientas de diagnóstico y caracterización que puedan contribuir a mejorar la eficiencia de los esfuerzos de erradicación. Esto se…
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