Investigación

Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model

Investigación publicada en Applied and Environmental Microbiology

The guts of animals and humans harbor diverse microbial communities that are regularly exposed to bacteria originating from food, water, and their surroundings. Species such as Escherichia coli are adept at colonizing multiple hosts, along with surviving in the environment. By encoding pathogenic traits and transmissible forms of antimicrobial resistance (AMR), E. coli can also pose a zoonotic risk. Our understanding of the factors that govern host residency is limited. Here, we used a chicken cecal fermentation model to study survival and the AMR transfer potential of 17 host-associated exten… Leer más

Néstor Porras, ACVP Editors Choice Award 2025

Su estudio de evaluación histopatológica en jabalíes infectados por el virus de la peste porcina africana, ha optenido el premio en la categoria de estudio experimental

Nuestro compañero Néstor Porras González, investigador del Servicio de Patología Animal y Veterinaria Forense del centro Visavet y estudiante de doctorado de la Facultad de Veterinaria UCM, ha sido selecionado por los editores de Veterinary Pathology para recibir el Premio de los Editores de American College Of Veterinary Pathology a un Estudio Experimental. Este premio ha reconocido en el artículo "Histopathologic evaluation system of African swine fever in wild boar infected with high (Arm07) and low (Lv17/WB/Riel) isolates" el diseño del estudio, la claridad, la presentación de los datos y el impacto potencial. El premio será entregado en la próxima Reunión Anual de la @americancollegevetpath ACVP en Nueva Orleans, Luisiana, EE. UU.… Leer más

Retrospective analysis of the clinical approach practiced in dog bite cases caused by Vipera latastei, Vipera seoanei and Vipera aspis

Artículo de investigación publicado en The Veterinary Journal

Snakebites pose a significant public health risk to both humans and animals in many countries. In Spain, the presence of three viper species, Vipera latastei, Vipera seoanei, and Vipera aspis, complicates clinical management in veterinary settings. There is currently no standardized veterinary protocol for treating viper bites in many countries. This retrospective study analyzed the clinical approaches employed by Spanish veterinary centers in treating canine viper bites within the distribution range of these species. Data from 62 clinical cases across 58 veterinary centers were reviewed, incl… Leer más

Epidemiología de la resistencia a aminoglucósidos y macrólidos en Campylobacter termotolerantes en animales de abasto en España

Tesis Doctoral defendida por Vicente López Chavarrías en el Centro VISAVET de la Universidad Computense de Madrid

La resistencia a los antimicrobianos es un problema importante para el tratamiento de enfermedades causadas por bacterias zoonóticas como Campylobacter termotolerantes (C. coli y C. jejuni). Los mecanismos mediante los cuales la resistencia a los antimicrobianos se propaga en las poblaciones bacterianas, especialmente a través de transferencia horizontal de genes, pueden tener graves consecuencias dependiendo de la velocidad con que los fenotipos resistentes se diseminan entre animales de producción, los seres humanos y el medio ambiente. Son particularmente relevantes los determinantes gen… Leer más

The impact of mycobacteria-induced trained immunity on SARS-CoV-2 vaccine responses

Artículo de investigación publicado en Frontiers in immunology

Introduction: Beyond the role of Bacillus Calmette-Guérin (BCG) for tuberculosis prevention, BCG has demonstrated heterologous protective effects. The global health crisis caused by the SARS-CoV-2 virus led to research on whether BCG-induced trained immunity could strengthen antiviral defenses. However, studies reported quite different results on its effect against COVID-19. Methods and results: In this study, we evaluated the impact of pre-existing trained immunity induced by a BCG-derived Mycobacterium bovis strain (dpB), in both live and inactivated forms, in combination with SARS-CoV-2 v… Leer más

Oral fluid collection in wild boar: A field protocol

Artículo de investigación publicado en The Veterinary Journal

Traditional wildlife sampling methods have limitations in providing a well-distributed, timely and accurate disease surveillance in wildlife. We developed a field protocol for collecting wild boar (Sus scrofa) oral fluid samples for non-invasive active disease surveillance using environmental ropes. We deployed ropes in field settings and tested the rope-sampled oral fluids for antibodies against Mycobacterium bovis and closely related members of the Mycobacterium tuberculosis complex (MTC). Oral fluid samples were collected from three wild boars populations in Spain with endemic tuberculosis … Leer más

Systematic Review of the Ovitrap Surveillance of Aedes Mosquitoes in Brazil (2012–2022)

Investigación publicada en Travel Medicine and Infectious Disease

Background: Arthropod-borne diseases primarily affect tropical and subtropical regions, exhibiting seasonal patterns that peak during hot and rainy months when conditions favor mosquito vector proliferation. Factors such as high temperatures, elevated humidity, rainfall, urbanization, and the abundance of natural and artificial breeding sites influence Aedes vector dynamics. In this context, arboviruses pose significant public health challenges, likely worsened by global warming. In Brazil, Aedes (Stegomyia) aegypti (Linnaeus, 1762) is the primary vector for yellow fever, dengue, chikungunya, … Leer más

Field evaluation of the P22 ELISA for diagnosis of caprine tuberculosis in an endemic area

Frontiers in veterinary science publica este artículo de investigación

Animal tuberculosis (TB) affects a wide range of domestic species, including goats. TB eradication programs in goats are based on cell-based techniques such as the single and comparative intradermal tuberculin test (SITT and CITT, respectively). In recent years, an ELISA technique based on the P22 protein complex (P22 ELISA), has emerged as a valuable tool for TB diagnosis. The aim of the study was to evaluate the performance of the P22 ELISA in the context of a caprine TB eradication program using serum, individual milk and bulk tank milk (BTM) samples in order to define its usefulness in cla… Leer más

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria

Investigación publicada en Nature Communications

The npmA gene, encoding a 16S rRNA methyltransferase, confers resistance to all clinically available aminoglycosides, posing a significant threat to effective antibiotic therapy. We analyze 1,932,812 bacterial genomes to investigate the distribution and mobilization of npmA variants. npmA is not found in Gram-negative bacteria, where it was originally described, but is identified among Gram-positive bacteria, predominantly as the npmA2 variant in the globally distributed Clostridioides difficile ST11 lineage. We also detect npmA2 in two vancomycin-resistant Enterococcus faecium isolates from a… Leer más

- Confirman la extensión global de un gen que crea bacterias resistentes a los antibióticos - canalsur.es

- Veterinarios españoles descubren un gen que hace invencibles a las bacterias frente a antibióticos y que se propaga por todo el mundo - animalshealth.es

- Alarma global por un gen que vuelve invencibles a bacterias frente a antibióticos clave - eldiariodemadrid.es

- Este Gen Crea Bacterias Resistentes a Antibióticos y Ya se Extendió a Nivel Global - nmas.com

- Un gen provoca que las bacterias sean invencibles ante los antibióticos: se propaga por todo el mundo - cope.es

- Un gen que convierte las bacterias en resistentes a los antibióticos campa por hospitales y granjas de seis países - lavozdegalicia.es

- Un estudio confirma la existencia de un gen que da origen a bacterias resistentes a antibióticos - lavanguardia.com

- Un gen que hace de las infecciones bacterianas algo incurable se extiende a nivel global - elindependiente.com

- Un gen capaz de hacer a las bacterias totalmente resistentes se está propagando por todo el mundo - isanidad.com

- Un estudio liderado por el veterinario Bruno González-Zorn descubre cómo un gen se expande por todo el mundo generando superbacterias - diarioveterinario.com

- Científicos de la Universidad Complutense de Madrid confirman que un gen que hace invencibles a bacterias frente a antibióticos vitales se propaga por todo el mundo - innovaspain.com

- Alertan de la rápida propagación por todo el mundo de un gen que hace a las bacterias resistentes a los antibióticos - eldiario.es

- Un gen que convierte las bacterias en superbacterias se extiende por hospitales y granjas - elpais.com

Estudio histopatológico e inmunohistoquímico de la expresión de integrinas en el carcinoma gástrico canino

Trabajo Fin de Grado defendido por Adrian Arribas Mercado

Gastric carcinoma represents 60–70% of gastric neoplasms in dogs. The malignancy of these neoplasms is based on cellular characteristics such as pleomorphism, anisocytosis, anisokaryosis, atypical mitoses and mitotic index among others; but undoubtedly, migration, infiltration and metastasis of neoplastic cells are the criteria that determine the invasiveness of a tumor. These criteria can be determined by immunohistochemical study of certain transmembrane proteins called integrins. These molecules are composed of two separate subunits, ? (alpha) and ? (beta) subunits, which combine to form … Leer más