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Emergent subtype of hepatitis E virus genotype 3 in wild boar in Spain

Transboundary and Emerging Diseases publish this investigation article

September 24th, 2019

Wild boar (Sus scrofa) is considered the main wildlife reservoir of zoonotic hepatitis E virus (HEV) genotypes. The aim of this study was to evaluate the circulation of HEV in free-ranging wild boar in the Doñana National Park (DNP), Spain. Blood samples were collected from 99 wild boar in the DNP during 2015. Sera were analyzed in parallel using indirect ELISA and real-time RT-PCR. A total of 57 of the 99 tested animals (57.6%; 95%CI: 47.8-67.3%) had anti-HEV antibodies, indicating that this virus is widespread in wild boar in the DNP. HEV RNA was detected in one animal and phylogenetic analysis showed that the sequence isolated belonged to subtype 3r. The results suggest a potential risk of zoonotic transmission of this novel HEV-3 subtype, which could be of public health concern. Further studies are required to assess the role of wild boar in the epidemiology of HEV-3r and to determine the infectivity of this emergent HEV subtype in other species, including humans. This article is protected by copyright. All rights reserved




Caballero-Gomez J., Jiménez-Ruiz S., Lopez-Lopez P., Vicente J., Risalde MA., Cano-Terriza D., Frias M., Barasona JA., Rivero A., Garcia-Bocanegra I. and Rivero-Juarez A.




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Emergent subtype of hepatitis E virus genotype 3 in wild boar in Spain

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Emergent subtype of hepatitis E virus genotype 3 in wild boar in Spain

Participants:

Universidad de CórdobaDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Instituto Maimonides de Investigación Biomédica de CordobaUnidad de Enfermedades Infecciosas. Hospital Universitario Reina Sofía de Córdoba. Instituto Maimonides de Investigación Biomédica de Cordoba.

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Universidad de CórdobaDepartamento de Anatomía y Anatomía Patológica Comparadas. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







Transboundary and Emerging Diseases
FACTOR YEAR Q
3.554 2018

NLMID: 101319538

PMID: 31127865

ISSN: 1865-1674



TITLE: Emergent subtype of hepatitis E virus genotype 3 in wild boar in Spain


JOURNAL: Transbound. Emerg. Dis.


NUMERACIÓN: 66(5):1803-1808


AÑO: 2019


PUBLISHER: Blackwell Verlag


AUTHORS: Caballero-Gomez J., Jiménez-Ruiz S., Lopez-Lopez P., Vicente J., Risalde MA., Cano-Terriza D., Frias M., Barasona JA., Rivero A., Garcia-Bocanegra I. and Rivero-Juarez A.


VISAVET PARTICIPANTS


José Ángel Barasona García-Arévalo

DOI: https://doi.org/ 10.1111/tbed.13251


CITE THIS PUBLICATION:

Caballero-Gomez J., Jiménez-Ruiz S., Lopez-Lopez P., Vicente J., Risalde MA., Cano-Terriza D., Frias M., Barasona JA., Rivero A., Garcia-Bocanegra I. and Rivero-Juarez A. Emergent subtype of hepatitis E virus genotype 3 in wild boar in Spain. Transboundary and Emerging Diseases. 66(5):1803-1808. 2019. (A). ISSN: 1865-1674. DOI: 10.1111/tbed.13251


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