January, 2025 news
January 13rd, 2025
Via publiDB
Nuevos avances en el conocimiento de la resistencia antimicrobiana de las bacterias
Oficina de Transferencia de Resultados de Investigación (OTRI) publish this article
Un equipo de investigación de la Universidad Complutense de Madrid (UCM) avanza en el estudio de los genes de resistencia a los antibióticos de las bacterias, señalando la importancia del primer gen de los integrones en la expresión del resto. Este resultado abre una nueva puerta al desarrollo de tratamientos más dirigidos y eficaces.…
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January 1st, 2025
Via publiDB
Immunological mechanisms involved in the protection against development of pulmonary tuberculosis in naturally infected goats
Investigation article published in Veterinary Microbiology
Tuberculosis (TB) is a notifiable zoonotic disease caused by bacteria of the Mycobacterium tuberculosis complex (MTBC) that affects a multitude of domestic and wild species. The main lesions caused by these mycobacteria are tuberculous granulomas, which determine the organism`s immune response to the disease. Although TB pathogenesis in cattle has been extensively studied, information regarding its progression in other species of interest for the maintenance and transmission of TB such as goats remains limited. This study aimed to characterise the immune response developed in the lungs of goat…
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January 1st, 2025
Via publiDB
NpmC - a novel A1408 16S rRNA methyltransferase in the gut of humans and animals
International Journal of Antimicrobial Agents publish this investigation article
16S rRNA methyltransferases that act on residue A1408, NpmA and NpmB, confer high-level resistance to virtually all the aminoglycosides, but their reports are scarce. Analysing metagenomic projects in a One Health context, we identified in human and animal gut microbiomes from China and Canada a novel gene, npmC, that shares an identity of 91.5% with npmA, and up to 92.7% at amino acidic level. The protein encoded by this gene presents the conserved motifs required for A1408 methylation. Expression of the gene resulted in high-level of resistance to 4,5-disubstituted 2-deoxystreptamine (2-DOS)…
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