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Prevalence and time trend analysis of antimicrobial resistance in respiratory bacterial pathogens collected from diseased pigs in USA between 2006-2016

Investigation article published in Research in Veterinary Science

February 1st, 2020

Swine respiratory disease complex (SRDC) causes massive economic losses to the swine industry and is a major animal welfare concern. Antimicrobials are mainstay in treatment and control of SRDC. However, there is a lack of data on the prevalence and trends in resistance to antimicrobials in bacterial pathogens associated with SRDC. The objective of this study was to estimate the prevalence and changes in resistance to 13 antimicrobials in swine bacterial pathogens (Streptococcus suis, Pasteurella multocida, Actinobacillus suis and Haemophilus parasuis) in the U.S.A using data collected at University of Minnesota Veterinary Diagnostic Laboratory between 2006 and 2016. For antimicrobials for which breakpoints were available, prevalence of resistance remained below 10% except for tetracycline in S. suis and P. multocida isolates, and these prevalence estimates remained consistently low over the years despite statistical significance (p < .05) in trend analysis. For antimicrobial-bacterial combinations without available breakpoints, the odds of isolates being resistant increased by >10% annually for 7 and 1 antimicrobials in H. parasuis and S. suis isolates respectively, and decreased >10% annually for 4 and 1 antimicrobials in A. suis and H. parasuis isolates, respectively, according to the ordinal regression models. Clinical implications of changes in AMR for A. suis and H. parasuis should be interpreted cautiously due to the lack of interpretive criteria and challenges in antimicrobial susceptibility tests in the case of H. parasuis. Future studies should focus on surveillance of antimicrobial resistance and establishment of standardized susceptibility testing methodologies and interpretive criteria for these animal pathogens of critical importance




Hayer SS., Rovira A., Olsen K., Johnson TJ., Vannucci F., Rendahl A., Perez A. and Alvarez J..




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Prevalence and time trend analysis of antimicrobial resistance in respiratory bacterial pathogens collected from diseased pigs in USA between 2006-2016

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Prevalence and time trend analysis of antimicrobial resistance in respiratory bacterial pathogens collected from diseased pigs in USA between 2006-2016


Participants:

University of MinnesotaDepartment of Veterinary Population Medicine. Veterinary Diagnostic Laboratory. Department of Veterinary and Biomedical Sciences. College of Veterinary Medicine. University of Minnesota (UMM).

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Research in Veterinary Science
FACTOR YEAR Q
1.751 2018

NLMID: 401300

PMID: 31785428

ISSN: 0034-5288



TITLE: Prevalence and time trend analysis of antimicrobial resistance in respiratory bacterial pathogens collected from diseased pigs in USA between 2006-2016


JOURNAL: Res. Vet. Sci.


NUMERACIÓN: 128:135-144


AÑO: 2020


PUBLISHER: Elsevier


AUTHORS: Hayer SS., Rovira A., Olsen K., Johnson TJ., Vannucci F., Rendahl A., Perez A. and Alvarez J..


VISAVET PARTICIPANTS


Julio Álvarez Sánchez

DOI: https://doi.org/ 10.1016/j.rvsc.2019.11.010


CITE THIS PUBLICATION:

Hayer SS., Rovira A., Olsen K., Johnson TJ., Vannucci F., Rendahl A., Perez A. and Alvarez J. Prevalence and time trend analysis of antimicrobial resistance in respiratory bacterial pathogens collected from diseased pigs in USA between 2006-2016. Research in Veterinary Science. 128:135-144. 2020. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2019.11.010