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Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation


In Press

Investigación publicada en Nature ecology & evolution


Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes, but trade-offs between new and ancestral protein functions are pervasive and constrain the evolution of innovation. Classical models posit that evolutionary innovation circumvents the constraints imposed by trade-offs through genetic amplifications, which provide functional redundancy. Bacterial multicopy plasmids provide a paradigmatic example of genetic amplification, yet their role in evolutionary innovation remains largely unexplored. Here, we reconstructed the evolution of a new trait encoded in a multicopy plasmid using TEM-1 β-lactamase as a model system. Through a combination of theory and experimentation, we show that multicopy plasmids promote the coexistence of ancestral and novel traits for dozens of generations, allowing bacteria to escape the evolutionary constraints imposed by trade-offs. Our results suggest that multicopy plasmids are excellent platforms for evolutionary innovation, contributing to explain their extreme abundance in bacteria




Rodriguez Beltran J., Hernandez Beltran JCR., de la Fuente J., Escudero JA., Fuentes Hernandez A., Craig MacLean R., Pena Miller R. y San Millan A.




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Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation

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Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation

Participantes:

Comunidad de MadridInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS). Universidad Complutense (UCM). Universidad Autónoma de Madrid (UAM). Universidad de Alcalá (UAH). Salud Madrid. Comunidad de Madrid.

Comunidad de MadridServicio de Microbiología. Hospital Universitario Ramón y Cajal. Salud Madrid. Comunidad de Madrid.

Universidad Nacional Autónoma de MéxicoCentro de Ciencias Genómicas. Universidad Nacional Autónoma de México (UNAM).

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

University of OxfordDepartment of Zoology. University of Oxford.

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP). Instituto de Salud Carlos III (ISCIII).







FACTOR YEAR Q
2.440 2016

NLMID: 101698577

PMID: 29632354

ISSN: 2397-334X



TÍTULO: Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation


REVISTA: Nat Ecol Evol


EDITORIAL: Springer Nature


AUTORES: Rodriguez Beltran J., Hernandez Beltran JCR., de la Fuente J., Escudero JA., Fuentes Hernandez A., Craig MacLean R., Pena Miller R. and San Millan A.


PARTICIPANTES VISAVET


José Antonio Escudero García-Calderón

DOI: https://doi.org/10.1038/s41559-018-0529-z


CITA ESTA PUBLICACIÓN:

Rodriguez Beltran J., Hernandez Beltran JCR., de la Fuente J., Escudero JA., Fuentes Hernandez A., Craig MacLean R., Pena Miller R. y San Millan A. Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation. Nature ecology & evolution. In Press. (A). ISSN: 2397-334X. DOI: 10.1038/s41559-018-0529-z


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