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Noticias de marzo de 2023

30 de marzo de 2023

Vía publiDB

España está en una situación de riesgo ante la mayor pandemia conocida de PPA

Entrevista concedida a Interempresas Media

24 de marzo de 2023

Vía publiDB

Microbial Genomics

Global scenario of the RmtE pan-aminoglycoside-resistance mechanism: emergence of the rmtE4 gene in South America associated with a hospital-related IncL plasmid

Investigación publicada en Microbial Genomics

Antimicrobial resistance (AMR) mechanisms, especially those conferring resistance to critically important antibiotics, are a great concern for public health. 16S rRNA methyltransferases (16S-RMTases) abolish the effectiveness of most clinically used aminoglycosides, but some of them are considered sporadic, such as RmtE. The main goals of this work were the genomic analysis of bacteria producing 16S-RMTases from a ‘One Health’ perspective in Venezuela, and the study of the epidemiological and evolutionary scenario of RmtE variants and their related mobile genetic elements (MGEs) worldwide. A t… Leer más

24 de marzo de 2023

Vía publiDB

Red de Investigación en Sanidad Animal (RISA)

La secuenciación masiva al servicio de la Tuberculosis

Nuevo artículo online de divulgación publicado en Actualidad

El día 24 de marzo es una fecha señalada; en 1882, tal día como hoy, el Dr. Robert Koch anunciaba el descubrimiento del “bacilo tuberculoso” o Mycobacterium tuberculosis, la bacteria causante de la tuberculosis (TB). Para muchas personas esta enfermedad infecciosa suena a algo lejano y propio de las películas o novelas victorianas. Sin embargo, la realidad es bien distinta: la TB es posiblemente una de las enfermedades infecciosas más relevantes para el ser humano. Con excepción de la irrupción temporal de la COVID-19 durante la pandemia, la TB es, con diferencia, la principal causa de mortali… Leer más

24 de marzo de 2023

Vía publiDB

The increasing use of molecular diagnostics in the fight against bovine TB

Comunicación online en World TB day. Diagnostics and science: a One Health perspective

18 de marzo de 2023

Vía publiDB

International Journal of Molecualr Sciences

Drug Repositioning as a Therapeutic Strategy against Streptococcus pneumoniae: Cell Membrane as Potential Target

Artículo de investigación publicado en International Journal of Molecualr Sciences

A collection of repurposing drugs (Prestwick Chemical Library) containing 1200 compounds was screened to investigate the drugs` antimicrobial effects against planktonic cultures of the respiratory pathogen Streptococcus pneumoniae. After four discrimination rounds, a set of seven compounds was finally selected, namely (i) clofilium tosylate; (ii) vanoxerine; (iii) mitoxantrone dihydrochloride; (iv) amiodarone hydrochloride; (v) tamoxifen citrate; (vi) terfenadine; and (vii) clomiphene citrate (Z, E). These molecules arrested pneumococcal growth in a liquid medium and induced a decrease in bact… Leer más

14 de marzo de 2023

Vía publiDB

La popular bacteria que ya no responde a los antibióticos: crece el miedo a la disentería

Entrevista concedida a Salud. El Español

EEUU ha emitido una alerta por el aumento de una cepa de `Shigella` resistente a los medicamentos. En 2022, España dio también voz de alarma… Leer más

8 de marzo de 2023

Vía publiDB

Frontiers in Public Health

One Health surveillance - cross-sectoral detection, characterisation, and notification of foodborne pathogens

Investigación publicada en Frontiers in Public Health

Several Proficiency Test (PT) or External Quality Assessment (EQA) schemes are currently available for assessing the ability of laboratories to detect and characterise enteropathogenic bacteria, but they are usually targeting one sector, covering either public health, food safety or animal health. In addition to sector-specific PTs/EQAs for detection, cross-sectoral panels would be useful for assessment of the capacity to detect and characterise foodborne pathogens in a One Health (OH) perspective and further improving food safety and interpretation of cross-sectoral surveillance data. The aim… Leer más

6 de marzo de 2023

Vía publiDB


A useful tool for the safe diagnosis and control of the two main pandemics of the XXI century: COVID-19 and African Swine Fever disease

PLoS ONE publica este artículo de investigación

The COVID-19 pandemic and the disease triggered by the African Swine Fever virus are currently two of the main problems regarding public and animal health, respectively. Although vaccination seems to be the ideal tool for controlling these diseases, it has several limitations. Therefore, early detection of the pathogen is critical in order to apply preventive and control measures. Real-time PCR is the main technique used for the detection of both viruses, which requires previous processing of the infectious material. If the potentially infected sample is inactivated at the time of sampling, th… Leer más

1 de marzo de 2023

Vía publiDB

Aging cell

Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice

Aging cell publica este artículo de investigación

The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) signi… Leer más

1 de marzo de 2023

Vía publiDB

Preventive Veterinary Medicine

Struggling to improve farm biosecurity: Do free advice and subsidies hit the target?

Preventive Veterinary Medicine publica este artículo de investigación

Biosafety measures (BSMs) often aim at reducing the likelihood of cross-species interactions at the wildlife-livestock interface. Examples include means to segregate wild ungulates from cattle at waterholes or at feeders. Subsidies or incentives for BSM implementation are expected to contribute to improved BSM acceptance. However, several recent experiences led us to write a cautionary commentary on the variable success of incentives in farm biosafety promotion. We list examples where, after offering farm-specific biosecurity action plans for free or subsidizing 100% of the cost of a given BSM… Leer más

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