Translating eco-evolutionary biology into therapy to tackle antibiotic resistance
Investigación publicada en Nature reviews. Microbiology
1 de octubre de 2023
Antibiotic resistance is currently one of the most important public health problems. The golden age of antibiotic discovery ended decades ago, and new approaches are urgently needed. Therefore, preserving the efficacy of the antibiotics currently in use and developing compounds and strategies that specifically target antibiotic-resistant pathogens is critical. The identification of robust trends of antibiotic resistance evolution and of its associated trade-offs, such as collateral sensitivity or fitness costs, is invaluable for the design of rational evolution-based, ecology-based treatment approaches. In this Review, we discuss these evolutionary trade-offs and how such knowledge can aid in informing combination or alternating antibiotic therapies against bacterial infections. In addition, we discuss how targeting bacterial metabolism can enhance drug activity and impair antibiotic resistance evolution. Finally, we explore how an improved understanding of the original physiological function of antibiotic resistance determinants, which have evolved to reach clinical resistance after a process of historical contingency, may help to tackle antibiotic resistance
Sanz-García F., Gil-Gil T., Laborda P., Blanco P., Ochoa-Sanchez LE., Baquero F., Martinez JL. y Hernando-Amado S.
 | Departamento de Microbiología, Medicina Preventiva y Salud Pública. Facultad de Medicina. Universidad de Zaragoza (UNIZAR). |
 | Centro Nacional de Biotecnología (CNB). Consejo Superior de Investigaciones Científicas (CSIC). |
 | Programa de Doctorado en Biociencias Moleculares. Universidad Autónoma de Madrid (UAM). |
 | The Novo Nordisk Foundation Center for Biosustainability. Technical University of Denmark (DTU). |
 | Department of Clinical Microbiology. Aarhus University Hospital (AUH). |
 | Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
| Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
 | Department of Microbiology. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS). Universidad Complutense (UCM). Universidad Autónoma de Madrid (UAM). Universidad de Alcalá (UAH). Salud Madrid. Comunidad de Madrid. |
 | Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP). Instituto de Salud Carlos III (ISCIII). |
