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Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004

Investigation published in Antimicrobial Agents and Chemotherapy

May 1st, 2015

We describe the genetic background of blaTEM-4 and the complete sequence of pRYC11::blaTEM-4, a mosaic plasmid highly similar to pKpQIL-like variants, predominant among TEM-4 producers in a Spanish hospital (1990-2004) which belong to Klebsiella pneumoniae and Escherichia coli high-risk clones responsible for the current spread of different antibiotic resistance genes. Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins




Rodriguez I., Novais A., Lira F., Valverde A., Curiao T., Martinez JL., Baquero F., Canton R. and Coque TM.




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Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004

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Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004



Participants:

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP). Instituto de Salud Carlos III (ISCIII).

Universidade do PortoCentro de Investigação em Biodiversidade e Recursos Genétivos (CIBIO). Universidade do Porto (UP).

Consejo Superior de Investigaciones CientíficasCentro Nacional de Biotecnología (CNB). Consejo Superior de Investigaciones Científicas (CSIC).

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Instituto de Salud Carlos IIIRed Española de Investigación en Patología Infecciosa (REIPI). Instituto de Salud Carlos III (ISCIII).

Comunidad de MadridInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS). Universidad Complutense (UCM). Universidad Autónoma de Madrid (UAM). Universidad de Alcalá (UAH). Salud Madrid. Comunidad de Madrid.







Antimicrobial Agents and Chemotherapy
FACTOR YEAR Q
4.415 2015

NLMID: 315061

PMID: 25691645

ISSN: 0066-4804



TITLE: Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004


JOURNAL: Antimicrob. Agents Chemother.


NUMERACIÓN: 59(5):2904-8


AÑO: 2015


PUBLISHER: American Society for Microbiology


AUTHORS: Rodriguez I., Novais A., Lira F., Valverde A., Curiao T., Martinez JL., Baquero F., Canton R. and Coque TM.


DOI: https://doi.org/10.1128/AAC.00296-15


CITE THIS PUBLICATION:

Rodriguez I., Novais A., Lira F., Valverde A., Curiao T., Martinez JL., Baquero F., Canton R. and Coque TM. Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004. Antimicrobial Agents and Chemotherapy. 59(5):2904-8. 2015. (A). ISSN: 0066-4804. DOI: 10.1128/AAC.00296-15


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