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Approaches and Perspectives for Development of African Swine Fever Virus Vaccines

Vaccines publish this article

October 7th, 2017

Arias M., de la Torre A., Dixon L., Gallardo C., Jori F., Laddomada A., Martins C., Parkhouse RM., Revilla Y., Rodriguez F. and Sanchez-Vizcaino JM..


African swine fever (ASF) is a complex disease of swine, caused by a large DNA virus belonging to the family Asfarviridae. The disease shows variable clinical signs, with high case fatality rates, up to 100%, in the acute forms. ASF is currently present in Africa and Europe where it circulates in different scenarios causing a high socio-economic impact. In most affected regions, control has not been effective in part due to lack of a vaccine. The availability of an effective and safe ASFV vaccines would support and enforce control–eradication strategies. Therefore, work leading to the rational development of protective ASF vaccines is a high priority. Several factors have hindered vaccine development, including the complexity of the ASF virus particle and the large number of proteins encoded by its genome. Many of these virus proteins inhibit the host’s immune system thus facilitating virus replication and persistence. We review previous work aimed at understanding ASFV–host interactions, including mechanisms of protective immunity, and approaches for vaccine development. These include live attenuated vaccines, and “subunit” vaccines, based on DNA, proteins, or virus vectors. In the shorter to medium term, live attenuated vaccines are the most promising and best positioned candidates. Gaps and future research directions are evaluated





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Approaches and Perspectives for Development of African Swine Fever Virus Vaccines



Participants:

Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaEuropean Union Reference Laboratory for African Swine Fever. Centro de Investigación en Sanidad Animal (CISA). Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). 111

The Pirbright InstituteThe Pirbright Institute (TPI). 111

Animal, Santé, Territoires, Risques et Ecosystèmes (ASTRE). 111

Université de MontpellierUniversité de Montpellier (UM1). 111

Centre de Cooperation International en Recherche Agronomique pour le DeveloppementCentre de Cooperation International en Recherche Agronomique pour le Developpement (CIRAD). 111

Institut National de la Recherche AgronomiqueInstitut National de la Recherche Agronomique (INRA). 111

Istituto Zooprofilattico Sperimentale del Piemonte (IZSTO). 111

Universidade de LisboaFaculdade de Medicina Veterinaria. Universidade de Lisboa (ULisboa). 111

Instituto Gulbenkian de Ciência (IGC). 111

Consejo Superior de Investigaciones CientíficasCentro de Biología Molecular Severo Ochoa (CBMSO). Consejo Superior de Investigaciones Científicas (CSIC). Universidad Autónoma de Madrid (UAM). 111

Generalitat de CatalunyaInstituto de Investigación y Tecnología Agroalimentarias (IRTA). Generalitat de Catalunya. 111

Universitat Autònoma de BarcelonaCentre de Recerca en Sanitat Animal (CReSA). Universitat Autònoma de Barcelona (UAB). 111

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). 111

World Organisation for Animal HealthWorld Organisation for Animal Health (WOAH). 111








TITLE: Approaches and Perspectives for Development of African Swine Fever Virus Vaccines


TYPE: Article


AUTHORS: Arias M., de la Torre A., Dixon L., Gallardo C., Jori F., Laddomada A., Martins C., Parkhouse RM., Revilla Y., Rodriguez F. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


José Manuel Sánchez-Vizcaíno Rodríguez

JOURNAL: Vaccines


LANGUAJE: Spanish


ISBN: 0264-410X


NUMERATION: 5(4), 35


DATE: October 7th, 2017


PUBLISHING COMPANY: Basel, Switzerland : MDPI AG


DOI: https://doi.org/ 10.3390/vaccines5040035


CITE THIS PUBLICATION:

Arias M., de la Torre A., Dixon L., Gallardo C., Jori F., Laddomada A., Martins C., Parkhouse RM., Revilla Y., Rodriguez F. and Sanchez-Vizcaino JM. Approaches and Perspectives for Development of African Swine Fever Virus Vaccines.. Vaccines. 5(4), 35. Basel, Switzerland : MDPI AG. ISBN: 0264-410X. 2017. (Article)


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