Revista Complutense de Ciencias Veterinarias publish this article

July 1^st, 2009

Perez de Diego AC., del Carmen P., Carvajal J. and Sanchez-Vizcaino JM..

Bluetongue Virus disease is an infectous disease submitted to a sanitary control composed by several measures of prevention, and one of these measures is the vaccination of the sensible species. In the development of vaccines opposite to this disease, a new trend is the production of polyvalent vaccines by VLP`s technology (virus like particles). This work has had as aim to value by clinical survey, 2 VLP vaccines, for serotypes 1 and 1+4. The results confirm the
lack of fever, clinical signs and pathologic injuries in vaccinated animals opposite to control animals, which indicates that these new vaccines protect for the appearance of clinical signs

Clinical study of a trial on VLP vaccine for bluetongue virus serotypes 1 & 1+4 in sheep

	Servicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). 111
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). 111