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Assigning Defined Daily/Course Doses for Antimicrobials in Turkeys to Enable a Cross-Country Quantification and Comparison of Antimicrobial Use

Antibiotics publish this investigation article

August 12nd, 2021

Antimicrobial resistance (AMR) threatens our public health and is mainly driven by antimicrobial usage (AMU). For this reason the World Health Organization calls for detailed monitoring of AMU over all animal sectors involved. Therefore, we aimed to quantify AMU on turkey farms. First, turkey-specific Defined Daily Dose (DDDturkey) was determined. These were compared to the broiler alternative from the European Surveillance of Veterinary Antimicrobial Consumption (DDDvet), that mention DDDvet as a proxy for other poultry species. DDDturkey ranged from being 81.5% smaller to 48.5% larger compared to its DDDvet alternative for broilers. Second, antimicrobial treatments were registered on 60 turkey farms divided over France, Germany and Spain between 2014 and 2016 (20 flocks per country). Afterwards, AMU was quantified using treatment incidence (TI) per 100 days. TI expresses the percentage of the rearing period that the turkeys were treated with a standard dose of antimicrobials. Minimum, median and maximum TI at flock level and based on DDDturkey = 0.0, 10.0 and 65.7, respectively. Yet, a huge variation in amounts of antimicrobials used at flock level was observed, both within and between countries. Seven farms (12%) did not use any antimicrobials. Aminopenicillins, polymyxins, and fluoroquinolones were responsible for 72.2% of total AMU. The proportion of treating farms peaked on week five of the production cycle (41.7%), and 79.4% of the total AMU was administered in the first half of production. To conclude, not all DDDvet values for broilers can be applied to turkeys. Additionally, the results of AMU show potential for reducing and improving AMU on turkey farms, especially concerning the usage of critically important antimicrobials




Joosten P., Sarrazin S., Chauvin C., Moyano G., Wadepohl K., Van Gompel L., Wagenaar J., Dewulf J. and EFFORT Group.




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Assigning Defined Daily/Course Doses for Antimicrobials in Turkeys to Enable a Cross-Country Quantification and Comparison of Antimicrobial Use

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Assigning Defined Daily/Course Doses for Antimicrobials in Turkeys to Enable a Cross-Country Quantification and Comparison of Antimicrobial Use



Participants:

University of GhentDepartment of Reproduction, Obstetrics and Herd Health. Faculty of Veterinary Medicine. University of Ghent (UGENT).

Agence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travailAgence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travail (ANSES).

French Agency for Food. Environmental and Occupational Safety. National Agency for Veterinary Medicinal Products.

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

University of Veterinary Medicine Hannover (TiHo).

Utrecht UniversityInstitute for Risk Assessment Sciences. Utrecht University (UU).

Veterinary Epidemiology. Risk Analysis and Statistics. Wageningen Bioveterinary Research.

Utrecht UniversityDepartment of Infectious Diseases and Immunology. Faculty of Veterinary Medicine. Utrecht University (UU).







Antibiotics
FACTOR YEAR Q
4.639 2020

PMID: 34439021

ISSN: 2079-6382



TITLE: Assigning Defined Daily/Course Doses for Antimicrobials in Turkeys to Enable a Cross-Country Quantification and Comparison of Antimicrobial Use


JOURNAL: Antibiotics-Basel


NUMERACIÓN: 10(8):971


AÑO: 2021


PUBLISHER: MDPI


AUTHORS: Joosten P., Sarrazin S., Chauvin C., Moyano G., Wadepohl K., Van Gompel L., Wagenaar J., Dewulf J. and EFFORT Group.


DOI: https://doi.org/ 10.3390/antibiotics10080971


CITE THIS PUBLICATION:

Joosten P., Sarrazin S., Chauvin C., Moyano G., Wadepohl K., Van Gompel L., Wagenaar J., Dewulf J. and EFFORT Group. Assigning Defined Daily/Course Doses for Antimicrobials in Turkeys to Enable a Cross-Country Quantification and Comparison of Antimicrobial Use. Antibiotics. 10(8):971. 2021. (A). ISSN: 2079-6382. DOI: 10.3390/antibiotics10080971


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