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Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain

Investigation published in Microbial Drug Resistance (Larchmont, N.Y.)

October 1st, 2013

A screening of antimicrobial resistance and its genetic determinants has been performed on 300 Salmonella enterica isolates collected during 2004-2008 from human infections in Spain. Salmonella Typhimurium and Salmonella Enteritidis were the major serotypes, which were found with similar frequencies covering 80% of the bacterial collection. Salmonella Typhimurium isolates frequently shared low susceptibility to antimicrobials of the penta-resistance phenotype (ACSSuT) and/or cephalosporin resistance. The ACSSuT profile was found closely linked to int1-associated gene cassettes, with major elements carrying DNA fragments of 1.0 Kb (aadA2 gene) plus 1.2 Kb (blaPSE-1 gene) or 2.0 Kb (aadA1 and blaOXA-1 genes). Among these, ACSSuT and cephalosporin resistances were associated in Salmonella Typhimurium isolates expressing the blaOXA gene. β-lactamase activities were also detected from isolates carrying blaTEM, blaCMY, or blaSHV, although only the two last genes expressed extended-spectrum β-lactamases. The clonal analysis of S. enterica strains suggests that both horizontal and vertical transfer mechanisms are involved in the wide dissemination of their antimicrobial resistance




Campos MJ., Palomo G., Hormeno L., Ugarte-Ruiz M., Porrero MC., Herrera-Leon S., Vadillo S., Piriz S. and Quesada A.




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Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain

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Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain


Participants:

Instituto de Salud Carlos IIIServicio de Bacteriología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Instituto Politécnico de LeiriaEscola Superior de Turismo e Tecnologia do Mar. Instituto Politécnico de Leiria (IPL).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad de ExtremaduraDepartamento de Bioquímica, Biología Molecular y Genética. Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad de Extremadura (UNEX).







Microbial Drug Resistance (Larchmont, N.Y.)
FACTOR YEAR Q
2.524 2013

NLMID: 9508567

PMID: 23738829

ISSN: 1076-6294



TITLE: Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain


JOURNAL: Microb. Drug Resist


NUMERACIÓN: 19(5):384-91


AÑO: 2013


PUBLISHER: Mary Ann Liebert, Inc.


AUTHORS: Campos MJ., Palomo G., Hormeno L., Ugarte-Ruiz M., Porrero MC., Herrera-Leon S., Vadillo S., Piriz S. and Quesada A.


VISAVET PARTICIPANTS


María Ugarte Ruiz

DOI: https://doi.org/ 10.1089/mdr.2012.0261


CITE THIS PUBLICATION:

Campos MJ., Palomo G., Hormeno L., Ugarte-Ruiz M., Porrero MC., Herrera-Leon S., Vadillo S., Piriz S. and Quesada A. Co-Occurrence of ACSSuT and Cephalosporin Resistance Phenotypes Is Mediated by int1-associated elements in nontyphoidal Salmonella enterica from human infections in Spain. Microbial Drug Resistance (Larchmont, N.Y.). 19(5):384-91. 2013. (A). ISSN: 1076-6294. DOI: 10.1089/mdr.2012.0261


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