Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela
Antimicrobial Agents and Chemotherapy publish this investigation article
September 23rd, 2016
We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal and environmental Enterobacteriaceae from Cumana (Venezuela) collected in 2015. mcr-1 was detected in 2/93 Escherichia coli from swine and human isolates resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes
Delgado-Blas JF., Ovejero CM., Abadia-Patino L. and Gonzalez-Zorn B..
Participants:
 | Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
 | Department of Biomedicine. Instituto de Investigaciones en Biomedicina y Ciencias Aplicadas. Universidad de Oriente (UDO). |
