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Constant Hepatitis E Virus (HEV) Circulation in Wild Boar and Red Deer in Spain: An Increasing Concern Source of HEV Zoonotic Transmission

Investigation article published in Transboundary and Emerging Diseases

October 1st, 2016

Hepatitis E is a viral zoonosis that affects multiple hosts. The complete dynamics of infection in wildlife are still unknown, but the previous fact facilitates the maintenance and circulation of the virus, posing a risk to human health in the case of meat consumption from susceptible animals. In Spain, it has been shown how domestic pigs, cattle and wildlife (i.e. wild boar and red deer) clearly interact in hunting farms, generating a complex epidemiological situation in terms of interspecies pathogen transmission. Therefore, in this study, we aimed to (i) evaluate the circulation of the virus in geographically close domestic (Iberian pigs) and wild animals (wild boar and deer) living in hunting areas from central Spain over an 8-year period (2003-2010) and (ii) to determine whether HEV could be used as a marker of domestic-wildlife contact. For these purposes, a longitudinal analysis of Iberian pig, wild boar and red deer samples (n = 287) through virological and serological tests was conducted to shed light upon the circulation events of HEV. Regarding HEV RNA detection by real-time RT-PCR, 10.12% samples (95% CI: 5.44-14.8) from wild boar and 16.05% samples (95% CI: 8.06-24.04) from red deer were positive. As for the Iberian pigs, none of the 48 samples was positive for HEV RNA detection. In the serological analysis, 43.75% (95% CI: 29.75-57.75) from Iberian pig, 57.40% (95% CI: 48.10-66.70) from wild boar and 12.85% (95% CI: 5.01-20.69) samples from red deer presented anti-HEV antibodies. Positive samples were distributed among all study years (2003-2010). These results depict the urgent need to improve the inspection and surveillance of these species and their products. In the case of HEV, it is clear that the stable and constant presence of the virus in wildlife and its contact with Iberian pigs pose a risk for human health as they are all destined for human consumption




Kukielka D., Rodriguez-Prieto V., Vicente J. and Sanchez-Vizcaino JM..




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Constant Hepatitis E Virus (HEV) Circulation in Wild Boar and Red Deer in Spain: An Increasing Concern Source of HEV Zoonotic Transmission

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Constant Hepatitis E Virus (HEV) Circulation in Wild Boar and Red Deer in Spain: An Increasing Concern Source of HEV Zoonotic Transmission



Participants:

Universidad San Pablo CEUÁrea Microbiología. Facultad de Farmacia. Universidad San Pablo CEU.

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Transboundary and Emerging Diseases
FACTOR YEAR Q
3.585 2016

NLMID: 101319538

PMID: 25571944

ISSN: 1865-1674



TITLE: Constant Hepatitis E Virus (HEV) Circulation in Wild Boar and Red Deer in Spain: An Increasing Concern Source of HEV Zoonotic Transmission


JOURNAL: Transbound. Emerg. Dis.


NUMERACIÓN: 63(5):e360-8


AÑO: 2016


PUBLISHER: Blackwell Verlag


AUTHORS: Kukielka D., Rodriguez-Prieto V., Vicente J. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/ 10.1111/tbed.12311


CITE THIS PUBLICATION:

Kukielka D., Rodriguez-Prieto V., Vicente J. and Sanchez-Vizcaino JM. Constant Hepatitis E Virus (HEV) Circulation in Wild Boar and Red Deer in Spain: An Increasing Concern Source of HEV Zoonotic Transmission. Transboundary and Emerging Diseases. 63(5):e360-8. 2016. (A). ISSN: 1865-1674. DOI: 10.1111/tbed.12311


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