Microbiology and Immunology publish this investigation article

May 1^st, 2012

A CpG-enriched recombinant plasmid (pUC18-CpG) as an adjuvant of foot-and-mouth disease (FMD) killed vaccine was tested for immunization and vaccination challenge in a porcine model. Our preliminary results had indicated that the recombinant plasmid could enhance the humoral immune response triggered by the traditional oil-adjuvant vaccine after the initial inoculation. A subsequent vaccination-challenge test showed an increased PD(50) (50% protective dose) value. Thus, coadministration of the recombinant plasmid with the oil-adjuvant vaccine helped illicit an immune response earlier than that elicited by the administration of the vaccine alone. Our results showed that pUC18-CpG can be a potent immunoadjuvant for the traditional FMD killed vaccine and can greatly enhance the traditional vaccine`s efficacy when administered in combination with it

Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM..

CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine

CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine

	Servicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Institute of Animal Science (IAS). Chinese Academy of Agricultural Sciences (CAAS).
	College of Veterinary Medicine. Yangzhou University (YZU).
	Xinjiang Tiankang Animal Science Bio-Technology.