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European 1: A globally important clonal complex of Mycobacterium bovis

Investigation article published in Infection Genetics and Evolution

August 1st, 2011

We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14% of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle




Smith NH., Berg S., Dale J., Allen A., Rodriguez-Campos S., Romero B., Matos F., Ghebremichael S., Karoui C., Donati C., Da Conceicao Machado A., Mucavele C., Kazwala R., Hilty M., Cadmus S., Ngandolo BNR., Habtamu M., Oloya J., Muller A., Milian-Suazo F., Andrievskaia O., Projahn M., Barandiaran S., da Macias A., Muller B., Santos Zanini M., Yumi Ikuta C., Rosales CA., Pinheiro SR., Figueroa A., Cho S-N., Mosavari N., Chuang P-C., Jou R., Zinsstag J., van Soolingen D., Costello E., Aseffa A., Proano-Perez F., Portaels F., Rigouts L., Cataldi AA., Collins MD., Boschiroli L., Hewinson RG., Soares J., Surujballi O., Tadyon K., Botelho A., Zarraga AM., Buller N., Skuce R., Michel A., Aranaz A., Gordon SV., Jeon B-Y., Kallenius G., Niemann S., Boniotti B., van Helden P., Harris B., Zumarraga MJ. and Kremer K.




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European 1: A globally important clonal complex of Mycobacterium bovis

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European 1: A globally important clonal complex of Mycobacterium bovis



Participants:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

University of SussexCentre for the Study of Evolution (CSE). University of Sussex (US).

Department for Environment, Food and Rural AffairsAnimal Health and Veterinary Laboratories Agency (AHVLA). Department for Environment, Food and Rural Affairs (Defra).

Agri-Food and Biosciences Institute (AFBI).

Laboratório Nacional de Investigação Veterinária (LNIV). Instituto Nacional de Recursos Biologicos (INRB).

Department of Bacteriology. Swedish Institute for Infectious Disease Control.

Agence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travailUnité Zoonoses Bactériennes. Laboratoire de Santé Animale, Maisons-Alfort. Agence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travail (ANSES).

Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna (IZSLER).

Universidade Eduardo MondlaneFacultad d Veterinaria. Universidade Eduardo Mondlane (UEM).

Sokoine University of AgricultureSokoine University of Agriculture.

Department of Veterinary Public Health & Preventive Medicine. University of Ibadan (UI).

Laboratoire de Recherches Vétérinaire et Zootechnique de Farcha (LRVZ/F).

Armauer Hansen Research Institute (AHRI). East African Consortium for Clinical Research (EACCR).

University of GeorgiaDepartment of Epidemiology & Biostatistics. College of Public Health. University of Georgia (UGA).

Division of Molecular Biology and Human Genetics. Faculty of Health Sciences. Stellenbosch University (SUN).

Centro Nacional de Investigación Disciplinaria en Fisiología y Mejoramiento Animal. Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias (INIFAP).

Ottawa Laboratory Fallowfield Ottawa. Canadian Food Inspection Agency.

Molecular Microbiology and Genomics Consultants.

Szent István University (SZIU).

School of Veterinary Medicine. Universidad Nacional de Rio IV (UNRC).

Department Medicina Veterinária. Centro de Ciencias Agrárias. Universidade Federal do Espirito Santo (UFES).

Universidade de Sao PauloDepartamento de Medicina Veterinária Preventiva e Saúde Animal. Faculdade de Medicina Veterinária e Zootecnia. Universidade de Sao Paulo (USP).

Institute for Infectious Diseases. University of Bern (UNIBE).

Universidad de Buenos AiresFacultad de Ciencias Veterinarias. Universidad de Buenos Aires (UBA).

Universidad Austral de ChileInstituto de Bioquímica. Facultad de Ciencias. Universidad Austral de Chile (UACH).

Yonsei University College of MedicineDepartment of Microbiology. Yonsei University College of Medicine (YUCM).

PPD Tuberculin Department,. Razi Vaccine & Serum Research Institute.

Laboratory of Mycobacteriology. Research and Diagnostic Center. Department of Health People´s Republic of China.

Swiss Tropical and Public Health Institute (Swiss TPH).

National Institute for Public Health and the EnvironmentThe Netherlands Tuberculosis Reference Laboratory. Centre for Infectious Disease Control. National Institute for Public Health and the Environment (RIVM).

Central Veterinary Research Laboratory, Backweston Laboratory Complex. Department of Agriculture, Food and the Marine (DAFM).

Department of Microbiology. Institute of Tropical Medicine.

Instituto Nacional de Tecnología AgropecuariaInstituto de Biotecnología. Centro de Investigación de Ciencias Veterinarias y Agronómicas (CICVYA). Instituto Nacional de Tecnología Agropecuaria (INTA).

AgResearch. National Centre for Biosecurity and Infectious Disease (NCBID).

Department of Veterinary Aerobic Bacterial Research & Vaccine Production. Razi Vaccine & Serum Research Institute.

Laboratório Nacional de Investigação Veterinária (LNIV). Instituto Nacional de Recursos Biologicos (INRB).

Laboratory for Bovine Tuberculosis. Animal Health Laboratories (AHL). Department of Agriculture and Food Western Australia (DAFWA).

Faculty of Veterinary Science. University of Pretoria (UP).

Agricultural Research Council-Onderstepoort Veterinary Institute (ARC-OVI).

University College DublinUCD Conway Institute of Biomolecular & Biomedical Research. University College Dublin (UCD).

University College DublinUCD School of Agriculture, Food Science & Veterinary Medicine. University College Dublin (UCD).

University College DublinUCD School of Medicine & Medical Science. University College Dublin (UCD).

Department of Clinical Science and Education. Karolinska Institutet (KI).

U.S. Department of AgricultureNational Veterinary Services Laboratories, Mycobacteria and Brucella Section. Animal and Plant Health Inspection Services (APHIS). U.S. Department of Agriculture (USDA).







Infection Genetics and Evolution
FACTOR YEAR Q
3.128 2011

NLMID: 101084138

PMID: 21571099

ISSN: 1567-1348



TITLE: European 1: A globally important clonal complex of Mycobacterium bovis


JOURNAL: Infect Genet Evol


NUMERACIÓN: 11(6):1340-51


AÑO: 2011


PUBLISHER: Elsevier Science


AUTHORS: Smith NH., Berg S., Dale J., Allen A., Rodriguez-Campos S., Romero B., Matos F., Ghebremichael S., Karoui C., Donati C., Da Conceicao Machado A., Mucavele C., Kazwala R., Hilty M., Cadmus S., Ngandolo BNR., Habtamu M., Oloya J., Muller A., Milian-Suazo F., Andrievskaia O., Projahn M., Barandiaran S., da Macias A., Muller B., Santos Zanini M., Yumi Ikuta C., Rosales CA., Pinheiro SR., Figueroa A., Cho S-N., Mosavari N., Chuang P-C., Jou R., Zinsstag J., van Soolingen D., Costello E., Aseffa A., Proano-Perez F., Portaels F., Rigouts L., Cataldi AA., Collins MD., Boschiroli L., Hewinson RG., Soares J., Surujballi O., Tadyon K., Botelho A., Zarraga AM., Buller N., Skuce R., Michel A., Aranaz A., Gordon SV., Jeon B-Y., Kallenius G., Niemann S., Boniotti B., van Helden P., Harris B., Zumarraga MJ. and Kremer K.


VISAVET PARTICIPANTS


Beatriz Romero Martínez

DOI: https://doi.org/10.1016/j.meegid.2011.04.027


CITE THIS PUBLICATION:

Smith NH., Berg S., Dale J., Allen A., Rodriguez-Campos S., Romero B., Matos F., Ghebremichael S., Karoui C., Donati C., Da Conceicao Machado A., Mucavele C., Kazwala R., Hilty M., Cadmus S., Ngandolo BNR., Habtamu M., Oloya J., Muller A., Milian-Suazo F., Andrievskaia O., Projahn M., Barandiaran S., da Macias A., Muller B., Santos Zanini M., Yumi Ikuta C., Rosales CA., Pinheiro SR., Figueroa A., Cho S-N., Mosavari N., Chuang P-C., Jou R., Zinsstag J., van Soolingen D., Costello E., Aseffa A., Proano-Perez F., Portaels F., Rigouts L., Cataldi AA., Collins MD., Boschiroli L., Hewinson RG., Soares J., Surujballi O., Tadyon K., Botelho A., Zarraga AM., Buller N., Skuce R., Michel A., Aranaz A., Gordon SV., Jeon B-Y., Kallenius G., Niemann S., Boniotti B., van Helden P., Harris B., Zumarraga MJ. and Kremer K. European 1: A globally important clonal complex of Mycobacterium bovis. Infection Genetics and Evolution. 11(6):1340-51. 2011. (A). ISSN: 1567-1348. DOI: 10.1016/j.meegid.2011.04.027


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