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Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection

Investigation published in Veterinary Research Communications

September 1st, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current pandemic disease denominated as Coronavirus Disease 2019 (COVID-19). Several studies suggest that the original source of this virus was a spillover from an animal reservoir and its subsequent adaptation to humans. Of all the different animals affected, cats are one of the most susceptible species. Moreover, several cases of natural infection in domestic and stray cats have been reported in the last few months. Although experimental infection assays have demonstrated that cats are successfully infected and can transmit the virus to other cats by aerosol, the conditions used for these experiments have not been specified in terms of ventilation. We have, therefore, evaluated the susceptibility of cats using routes of infection similar to those expected under natural conditions (exposure to a sneeze, cough, or contaminated environment) by aerosol and oral infection. We have also evaluated the transmission capacity among infected and naïve cats using different air exchange levels. Despite being infected using natural routes and shed virus for a long period, the cats did not transmit the virus to contact cats when air renovation features were employed. The infected animals also developed gross and histological lesions in several organs. These outcomes confirm that cats are at risk of infection when exposed to infected people, but do not transmit the virus to other cats with high rates of air renovation




Barroso-Arevalo S., Sánchez-Morales L., Barasona JA., Rivera B., Sanchez R., Risalde MA., Argullo-Ros I. and Sanchez-Vizcaino JM..




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Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection

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Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection



Participants:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad de CórdobaDepartamento de Anatomía y Anatomía Patológica Comparadas. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Instituto Maimonides de Investigación Biomédica de CordobaUnidad de Enfermedades Infecciosas. Hospital Universitario Reina Sofía de Córdoba. Instituto Maimonides de Investigación Biomédica de Cordoba.







Veterinary Research Communications
FACTOR YEAR Q
2.816 2021

NLMID: 8100520

PMID: 35243589

ISSN: 0165-7380



TITLE: Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection


JOURNAL: Vet. Res. Commun.


NUMERACIÓN: 46(3):837-852


AÑO: 2022


PUBLISHER: Springer


AUTHORS: Barroso-Arevalo S., Sánchez-Morales L., Barasona JA., Rivera B., Sanchez R., Risalde MA., Argullo-Ros I. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


First
Sandra Barroso Arévalo
2nd
Lidia Sánchez Morales
3rd
José Ángel Barasona García-Arévalo
4th
Belén Rivera Arroyo
5th
Rocío Sánchez García
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.1007/s11259-022-09908-5


CITE THIS PUBLICATION:

Barroso-Arevalo S., Sánchez-Morales L., Barasona JA., Rivera B., Sanchez R., Risalde MA., Argullo-Ros I. and Sanchez-Vizcaino JM. Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection. Veterinary Research Communications. 46(3):837-852. 2022. (A). ISSN: 0165-7380. DOI: 10.1007/s11259-022-09908-5


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