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Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium

Investigation article published in Veterinary Microbiology

July 29th, 2010

The Eurasian wild boar (Sus scrofa) is increasingly relevant as a host for several pathogenic mycobacteria. We aimed to characterize the first experimental Mycobacterium avium subsp. avium (MAA) infection in wild boar in order to describe the lesions and the immune response as compared to uninfected controls. Twelve 1-4-month-old wild boar piglets were housed in class III bio-containment facilities. Four concentrations of MAA suspension were used: 10, 10(2) and 10(4) mycobacteria (2 animals each, oropharyngeal route) and 2.5x10(6) mycobacteria (2 animals each by the oropharyngeal and nasal routes). No clinical signs were observed and pathology evidenced a low pathogenicity of this MAA strain for this particular host. Bacteriological and pathological evidence of successful infection after experimental inoculation was found for the group challenged with 2.5x10(6) mycobacteria. These four wild boar showed a positive IFN-gamma response to the avian PPD and the real-time RT-PCR data revealed that three genes, complement component C3, IFN-gamma and RANTES, were significantly down regulated in infected animals. These results were similar to those found in naturally and experimentally M. bovis-infected wild boar and may constitute biomarkers of mycobacterial infection in this species. Copyright © 2010 Elsevier B.V. All rights reserved




Garrido JM., Vicente J., Carrasco-Garcia R., Galindo RC., Minguijon E., Ballesteros C., Aranaz A., Romero B., Sevilla I., de la Fuente J. and Gortazar C.




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Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium

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Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium



Participants:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Gobierno VascoNeiker-Tecnalia, Instituto Vasco de Investigación y Desarrollo Agrario. Gobierno Vasco.

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Oklahoma State UniversityDepartament of Veterinary Pathobiology. Center for Veterinary Health Sciences (CVHS). Oklahoma State University (OSU).







Veterinary Microbiology
FACTOR YEAR Q
3.256 2010

NLMID: 7705469

PMID: 20116184

ISSN: 0378-1135



TITLE: Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium


JOURNAL: Vet. Microbiol.


NUMERACIÓN: 144(1-2):240-245


AÑO: 2010


PUBLISHER: Elsevier Science Publishers


AUTHORS: Garrido JM., Vicente J., Carrasco-Garcia R., Galindo RC., Minguijon E., Ballesteros C., Aranaz A., Romero B., Sevilla I., de la Fuente J. and Gortazar C.


VISAVET PARTICIPANTS


Beatriz Romero Martínez

DOI: https://doi.org/10.1016/j.vetmic.2009.12.041


CITE THIS PUBLICATION:

Garrido JM., Vicente J., Carrasco-Garcia R., Galindo RC., Minguijon E., Ballesteros C., Aranaz A., Romero B., Sevilla I., de la Fuente J. and Gortazar C. Experimental infection of Eurasian wild boar with Mycobacterium avium subsp. avium. Veterinary Microbiology. 144(1-2):240-245. 2010. (A). ISSN: 0378-1135. DOI: 10.1016/j.vetmic.2009.12.041


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