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First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens)

Investigation published in BMC Veterinary Research

December 21st, 2014

BackgroundHerpesvirus and poxvirus can infect a wide range of species: herpesvirus genetic material has been detected and amplified in five species of the superfamily Pinnipedia; poxvirus genetic material, in eight species of Pinnipedia. To date, however, genetic material of these viruses has not been detected in walrus (Odobenus rosmarus), another marine mammal of the Pinnipedia clade, even though anti-herpesvirus antibodies have been detected in these animals.Case presentationIn February 2013, a 9-year-old healthy captive female Pacific walrus died unexpectedly at L¿Oceanografic (Valencia, Spain). Herpesvirus was detected in pharyngeal tonsil tissue by PCR. Phylogenetic analysis revealed that the virus belongs to the subfamily Gammaherpesvirinae. Poxvirus was also detected by PCR in skin, pre-scapular and tracheobronchial lymph nodes and tonsils. Gross lesions were not detected in any tissue, but histopathological analyses of pharyngeal tonsils and lymph nodes revealed remarkable lymphoid depletion and lymphocytolysis. Similar histopatholical lesions have been previously described in bovine calves infected with an alphaherpesvirus, and in northern elephant seals infected with a gammaherpesvirus that is closely related to the herpesvirus found in this case. Intracytoplasmic eosinophilic inclusion bodies, consistent with poxviral infection, were also observed in the epithelium of the tonsilar mucosa.ConclusionTo our knowledge, this is the first molecular identification of herpesvirus and poxvirus in a walrus. Neither virus was likely to have contributed directly to the death of our animal




Melero M., Garcia-Parraga D., Corpa JM., Ortega J., Rubio-Guerri C., Crespo JL., Rivera B. and Sanchez-Vizcaino JM..




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First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens)

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First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens)

Participants:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Generalitat ValencianaOceanogràfic. Ciudad de las Artes y las Ciencias. Generalitat Valenciana.

Universidad CEU Cardenal HerreraDepartamento Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos (PASAPTA). Facultad de Veterinaria. Universidad CEU Cardenal Herrera (CEU-UCH).







BMC Veterinary Research
FACTOR YEAR Q
1.777 2014

NLMID: 101249759

PMID: 25527906

ISSN: 1746-6148



TITLE: First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens)


JOURNAL: BMC Vet. Res


NUMERACIÓN: 10(1):968


AÑO: 2014


PUBLISHER: BioMed Central


AUTHORS: Melero M., Garcia-Parraga D., Corpa JM., Ortega J., Rubio-Guerri C., Crespo JL., Rivera B. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


First
Mar Melero Asensio
7th
Belén Rivera Arroyo
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/ 10.1186/s12917-014-0308-2


CITE THIS PUBLICATION:

Melero M., Garcia-Parraga D., Corpa JM., Ortega J., Rubio-Guerri C., Crespo JL., Rivera B. and Sanchez-Vizcaino JM. First molecular detection and characterization of herpesvirus and poxvirus in a Pacific walrus (Odobenus rosmarus divergens). BMC Veterinary Research. 10(1):968 . 2014. (A). ISSN: 1746-6148. DOI: 10.1186/s12917-014-0308-2


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