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Genomic Plasticity of Vibrio cholerae

Investigation published in International Microbiology

September 1st, 2017

Vibrio cholerae is one of the deadliest pathogens in the history of humankind. It is the causative agent of cholera, a disease characterized by a profuse and watery diarrhoea that still today causes 95.000 deaths worldwide every year. V. cholerae is a free living marine organism that interacts with and infects a variety of organisms, from amoeba to humans, including insects and crustaceans. The complexity of the lifestyle and ecology of V. cholerae suggests a high genetic and phenotypic plasticity. In this review, we will focus on two peculiar genomic features that enhance genetic plasticity in this bacterium: the division of its genome in two different chromosomes and the presence of the superintegron, a gene capture device that acts as a large, low-cost memory of adaptive functions, allowing V. cholerae to adapt rapidly

Escudero JA. and Mazel D.

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Genomic Plasticity of Vibrio cholerae

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Genomic Plasticity of Vibrio cholerae


Institut PasteurBacterial Genome Plasticity (BGP). Department of Genomes and Genetics. Institut Pasteur.

Centre National de la Recherche ScientifiqueCentre National de la Recherche Scientifique (CNRS).

Universidad ComplutenseBases Moleculares de Adaptación. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

International Microbiology
0.796 2017

NLMID: 9816585

PMID: 29446805

ISSN: 1139-6709

TITLE: Genomic Plasticity of Vibrio cholerae

JOURNAL: Int Microbiol

NUMERACIÓN: 20(3):138-148

AÑO: 2017

PUBLISHER: Viguera Editores

AUTHORS: Escudero JA. and Mazel D.

José Antonio Escudero García-Calderón

DOI: https://doi.org/10.2436/20.1501.01.295


Escudero JA. and Mazel D. Genomic Plasticity of Vibrio cholerae. International Microbiology . 20(3):138-148. 2017. (A). ISSN: 1139-6709. DOI: 10.2436/20.1501.01.295