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Identification of a novel peptide that determines plasmid host-species specificity

Poster communication in ISPB2022: International Symposium on Plasmid Biology 2022

September 18th, 2022

Wedel E., Bernabe-Balas C., Pulido-Vadillo M., Matamoros BR., Fernandez-Favieres FJ., Montero N., Mazel D. and Gonzalez-Zorn B.

Antimicrobial resistance in bacteria is one of the biggest threats to Public Health worldwide. Plasmid facilitate the vertical and horizontal spread of antimicrobial resistance genes between different bacteria. The host-range and the adaptation of a plasmid to new host determine the impact of plasmid in the spread of resistance. In this work, we describe a new peptide that prevents the adaptation of a narrow-host range plasmid pB1000, usually found in Pasteurellaceae to the novel host Eschericia coli. As an adaptive mechanism, the disruption of this peptide by ISs from the E. coli chromosome increases the stability of pB1000. Depending on the ISs itself the plasmid host-range is expanded or shifted




Participants:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Institut PasteurInstitut Pasteur.


Link to ISPB2022: International Symposium on Plasmid Biology 2022





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ISPB2022: International Symposium on Plasmid Biology 2022


September 18th-23rd, 2022
Madrid
Spain

TITLE: Identification of a novel peptide that determines plasmid host-species specificity


TYPE: Poster communication


AUTHORS: Wedel E., Bernabe-Balas C., Pulido-Vadillo M., Matamoros BR., Fernandez-Favieres FJ., Montero N., Mazel D. and Gonzalez-Zorn B.


VISAVET PARTICIPANTS


Last
Bruno González Zorn

DATE: September 18th, 2022


CITE THIS COMMUNICATION:

Wedel E., Bernabe-Balas C., Pulido-Vadillo M., Matamoros BR., Fernandez-Favieres FJ., Montero N., Mazel D. and Gonzalez-Zorn B. Identification of a novel peptide that determines plasmid host-species specificity. ISPB2022: International Symposium on Plasmid Biology 2022, International Society for Plasmid Biology, Center for Integrative Biology, Madrid, Spain, September 18th, 2022. (Poster communication)


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