Identification of a novel peptide that determines plasmid host-species specificity
Poster communication in ISPB2022: International Symposium on Plasmid Biology 2022
September 18th, 2022
Wedel E., Bernabe-Balas C., Pulido-Vadillo M., Matamoros BR., Fernandez-Favieres FJ., Montero N., Mazel D. and Gonzalez-Zorn B.
Antimicrobial resistance in bacteria is one of the biggest threats to Public Health worldwide. Plasmid facilitate the vertical and horizontal spread of antimicrobial resistance genes between different bacteria. The host-range and the adaptation of a plasmid to new host determine the impact of plasmid in the spread of resistance. In this work, we describe a new peptide that prevents the adaptation of a narrow-host range plasmid pB1000, usually found in Pasteurellaceae to the novel host Eschericia coli. As an adaptive mechanism, the disruption of this peptide by ISs from the E. coli chromosome increases the stability of pB1000. Depending on the ISs itself the plasmid host-range is expanded or shifted
 | Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
 | Institut Pasteur. |
Link to ISPB2022: International Symposium on Plasmid Biology 2022
