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Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain

Investigation article published in Transboundary and Emerging Diseases

In Press

Despite of controls and preventive measures implemented along the food chain, infection with non-typhoidal Salmonella (NTS) remains one of the major causes of foodborne disease worldwide. Poultry is considered one of the major sources of NTS. This has led to the implementation of monitoring and control programs in many countries (including Spain) to ensure that in poultry flocks infection is kept to a minimum and to allow the identification and monitoring of circulating NTS strains and their antimicrobial resistance (AMR) phenotypes. Here, we investigated the information from the monitoring program for AMR in Salmonella from poultry in Spain in 2011-2017 to assess the diversity in phenotypic resistance and to evaluate the program`s ability to detect multi-resistance patterns and emerging strains in the animal reservoir. Data on serotype and AMR to nine antimicrobials obtained from 3,047 NTS isolates from laying hens (n=1,060), broiler (n=765) and turkey (n=1,222) recovered during controls performed by the official veterinary services and food business operators were analysed using univariate and multivariate methods in order to describe host and serotype-specific profiles. Diversity and prevalence of phenotypic resistance to all but one of the antimicrobials (colistin) was higher in NTS from broiler and turkey compared with laying hen isolates. Certain combinations of serotype and AMR pattern (resistotype) were particularly linked with certain hosts (e.g., susceptible Enteritidis with laying hens, multi-drug resistant (MDR) Derby in turkey, MDR Kentucky in turkey and broiler). The widespread presence of certain serotype-resistotype combinations in certain hosts/years suggested the possible expansion of MDR strains in the animal reservoir. This study demonstrates the usefulness of the analysis of data from monitoring programs at the isolate level to detect emerging threats, and suggests aspects that should be subjected to further research to identify the forces driving the expansion/dominance of certain strains in the food chain. This article is protected by copyright. All rights reserved




Alvarez J., Lopez-Perez G., Muellner P., De Frutos C., Ahistrom C., Serrano T., Moreno MA., Duran M., Saez JL., Dominguez L. and Ugarte-Ruiz M..




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Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain

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Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain


Participants:

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Ministerio de Agricultura, Pesca y AlimentaciónSubdirección General de Sanidad e Higiene Animal y Trazabilidad. Dirección General de la Producción Agraria. Ministerio de Agricultura, Pesca y Alimentación (MAPA).

Epi-InteractiveEpi-Interactive.

University of MinnesotaDepartment of Veterinary Population Medicine. College of Veterinary Medicine. University of Minnesota (UMM).

Laboratorio Central de Veterinaria (LCV).

Grupo TragsaEmpresa de Tecnologías y Servicios Agrarios, S.A. (TRAGSATEC). Grupo Tragsa.







Transboundary and Emerging Diseases
FACTOR YEAR Q
3.554 2018

NLMID: 101319538

PMID: 31484211

ISSN: 1865-1674



TITLE: Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain


JOURNAL: Transbound. Emerg. Dis.


PUBLISHER: Blackwell Verlag


AUTHORS: Alvarez J., Lopez-Perez G., Muellner P., De Frutos C., Ahistrom C., Serrano T., Moreno MA., Duran M., Saez JL., Dominguez L. and Ugarte-Ruiz M..


VISAVET PARTICIPANTS


First
Julio Álvarez Sánchez
7th
Miguel Ángel Moreno Romo
10
Lucas Domínguez Rodríguez
Last
María Ugarte Ruiz

DOI: https://doi.org/ 10.1111/tbed.13346


CITE THIS PUBLICATION:

Alvarez J., Lopez-Perez G., Muellner P., De Frutos C., Ahistrom C., Serrano T., Moreno MA., Duran M., Saez JL., Dominguez L. and Ugarte-Ruiz M. Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain. Transboundary and Emerging Diseases. In Press. (A). ISSN: 1865-1674. DOI: 10.1111/tbed.13346